Substrate: SMAD4 (Transcription factor)
Seq-ID: Q13485 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13793   MED15_HUMAN
MINT-14687   CEBPB_HUMAN
MINT-15900   SMAD2_HUMAN
MINT-58494   RAB3B_MOUSE
MINT-58519   CHK1_MOUSE
MINT-58525   TOPK_MOUSE
MINT-61942   ZMYM2_HUMAN
MINT-61943   PIAS1_HUMAN
MINT-61949   SMAD3_HUMAN
MINT-61951   SMAD5_HUMAN
MINT-61952   MYOD1_HUMAN
MINT-61955   PR40A_HUMAN
MINT-61957   MCAF1_HUMAN
MINT-61958   RFX1_HUMAN
MINT-61961   DCP1A_HUMAN
MINT-61962   DCP1B_HUMAN
MINT-61963   HM20A_HUMAN
MINT-61967   VIGLN_HUMAN
MINT-61974   MK13_HUMAN
MINT-61976   EF1A1_HUMAN
MINT-61978   CNKR1_HUMAN
MINT-61980   UHRF2_HUMAN
MINT-61982   JUNB_HUMAN
MINT-61984   RU17_HUMAN
MINT-62001   SMAD1_HUMAN
MINT-67350   SMAD9_HUMAN
MINT-7289576   KGP1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
I-SMAD binding,
protein homodimerization activity,
R-SMAD binding,
promoter binding,
sequence-specific DNA binding transcription factor activity,
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity		 cytosol,
activin responsive factor complex		 positive regulation of pathway-restricted SMAD protein phosphorylation,
transcription,
BMP signaling pathway,
negative regulation of protein catabolic process,
response to hypoxia,
negative regulation of cell growth,
SMAD protein complex assembly,
SMAD protein signal transduction,
negative regulation of transcription, DNA-dependent,
positive regulation of transforming growth factor beta receptor signaling pathway,
regulation of transforming growth factor-beta2 production,
transforming growth factor beta receptor signaling pathway,
palate development,
positive regulation of SMAD protein nuclear translocation,
positive regulation of epithelial to mesenchymal transition
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 277 TWTGSRTAPYTPNLPHHQNGH MAPK3 12801888
LTP
0.81
 MOD_ProDKin_1
 - -
0.77
 - low

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