Substrate: RIK1 (Receptor-interacting serine/threonine-protein kinase)
Seq-ID: Q13546 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16075   NEMO_HUMAN
MINT-49038   HS71L_HUMAN
MINT-49039   GRP78_HUMAN
MINT-49040   HSP7C_HUMAN
MINT-49041   ADT2_HUMAN
MINT-49042   GRP75_HUMAN
MINT-49044   DNJA1_HUMAN
MINT-49046   PYR1_HUMAN
MINT-49047   ACTG_HUMAN
MINT-49051   TBB5_HUMAN
MINT-49052   TBB4_HUMAN
MINT-49053   HS90A_HUMAN
MINT-49055   HS90B_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
death receptor binding,
protein serine/threonine kinase activity,
death domain binding,
ATP binding		 death-inducing signaling complex,
receptor complex,
mitochondrion,
cytosol		 tumor necrosis factor-mediated signaling pathway,
induction of necroptosis by extracellular signals,
positive regulation of I-kappaB kinase/NF-kappaB cascade,
regulation of ATP:ADP antiporter activity,
activation of JUN kinase activity,
positive regulation of anti-apoptosis,
response to tumor necrosis factor,
protein amino acid autophosphorylation,
I-kappaB kinase/NF-kappaB cascade,
positive regulation of NF-kappaB transcription factor activity,
activation of pro-apoptotic gene products,
induction of apoptosis,
regulation of oxygen and reactive oxygen species metabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 320 NENAVVKRMQSLQLDCVAVPS - 18669648
HTP
1.00
 - COIL
0.38
 - medium
T 337 AVPSSRSNSATEQPGSLHSSQ - 18669648
HTP
0.28
 - -
0.77
 - medium
S 346 ATEQPGSLHSSQGLGMGPVEE - 18669648
HTP
1.00
 - -
0.73
 - medium
Y 384 LQSKLQDEANYHLYGSRMDRQ - 15144186
HTP
1.00
 - -
0.67
 - medium
Y 387 KLQDEANYHLYGSRMDRQTKQ - 15144186
HTP
0.48
 - -
0.73
 - medium
S 389 QDEANYHLYGSRMDRQTKQQP - 15144186
HTP
0.85
 - -
0.77
 - medium

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