Substrate: Caspase-8 precursor (Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death)
Seq-ID: Q14790 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-64185   VIME_HUMAN
MINT-64186   CHD3_HUMAN
MINT-4051509   ANDR_HUMAN
MINT-4051954   CASP8_MOUSE
MINT-4055317   TNR6_HUMAN
MINT-4055344   FADD_HUMAN
MINT-4055393   CASPA_HUMAN
MINT-4298716   C8AP2_HUMAN
MINT-4329763   NUCL_HUMAN
MINT-4329782   TOPRS_HUMAN
MINT-4329823   MK03_HUMAN
MINT-4329848   MK01_HUMAN
MINT-6175515   NUCB1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
identical protein binding,
cysteine-type endopeptidase activity		 death-inducing signaling complex,
cytosol,
cytoskeleton,
mitochondrial outer membrane		 induction of apoptosis by extracellular signals,
positive regulation of I-kappaB kinase/NF-kappaB cascade,
proteolysis involved in cellular protein catabolic process,
response to tumor necrosis factor,
activation of pro-apoptotic gene products
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 219 SDSPREQDSESQTLDKVYQMK - 17525332
HTP
0.97
 - -
0.60
 --
Y 334 YGTDGQEAPIYELTSQFTGLK - 15592455
HTP
0.08
 - CASc
0.26
 1QTN 69.87%
S 347 TSQFTGLKCPSLAGKPKVFFI MAPK14 14970175
LTP
1.00
 - CASc
0.10
 1QTN 24.59%

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