Substrate: Presenilin 2 (Integral membrane protein)
Seq-ID: Q61144 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
endopeptidase activity,
protein binding		 neuronal cell body,
cytosol,
integral to plasma membrane,
endoplasmic reticulum membrane,
Z disc,
Golgi membrane,
membrane fraction		 beta-amyloid metabolic process,
locomotion,
apoptosis,
thymus development,
brain morphogenesis,
protein transport,
regulation of epidermal growth factor receptor activity,
positive regulation of catalytic activity,
regulation of synaptic plasticity,
T cell activation involved in immune response,
hemopoietic progenitor cell differentiation,
positive regulation of apoptosis,
Notch signaling pathway,
anagen,
positive regulation of coagulation,
cardiac muscle contraction,
calcium ion transport,
cell fate specification,
memory,
T cell receptor signaling pathway,
myeloid leukocyte differentiation,
embryonic limb morphogenesis,
lung alveolus development,
forebrain development,
protein maturation by peptide bond cleavage,
somitogenesis,
negative regulation of protein amino acid phosphorylation,
negative regulation of apoptosis,
membrane protein ectodomain proteolysis,
dorsal/ventral neural tube patterning
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 25 DERTSLMSAESPTSRSCQEGR - 19144319
HTP
0.94
 - -
0.68
 - medium
S 30 LMSAESPTSRSCQEGRPGPED - 19144319
HTP
0.92
 - -
0.83
 - medium
S 52 ESTAQWRTQESEEDCEEDPDR - 17242355
HTP
0.30
 - -
0.73
 - medium
S 52 ESTAQWRTQESEEDCEEDPDR - 19144319
HTP
0.30
 - -
0.73
 - medium

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