Substrate: Hamartin (Implicated as a tumor suppressor)
Seq-ID: Q92574 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-16238   TSC2_HUMAN
MINT-50948   1433B_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
chaperone binding,
protein N-terminus binding		 TSC1-TSC2 complex,
lamellipodium,
cell cortex,
membrane		 regulation of phosphoprotein phosphatase activity,
negative regulation of protein ubiquitination,
negative regulation of cell proliferation,
negative regulation of TOR signaling cascade,
activation of Rho GTPase activity,
cell-matrix adhesion,
negative regulation of translation,
regulation of stress fiber assembly,
response to insulin stimulus,
rRNA export from nucleus,
positive regulation of focal adhesion assembly
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 417 VHISLPQATVTPPRKEERMDS CDK1 14551205
LTP
0.04
 MOD_CDK_SPxK_1
 - Hamartin
0.80
 - low
S 505 EPVVPRGGFDSPFYRDSLPGS - 15963462
LTP
1.00
 - Hamartin
0.68
 - low
S 505 EPVVPRGGFDSPFYRDSLPGS - 18088087
HTP
1.00
 - Hamartin
0.68
 - low
S 505 EPVVPRGGFDSPFYRDSLPGS - 18669648
HTP
1.00
 - Hamartin
0.68
 - low
S 511 GGFDSPFYRDSLPGSQRKTHS - 18669648
HTP
0.03
 - Hamartin
0.71
 - low
S 584 TSLETSIFTPSPCKIPPPTRV CDK1 14551205
LTP
1.00
 MOD_CDK_SPxK_1
 - Hamartin
0.58
 - low
S 598 IPPPTRVGFGSGQPPPYDHLF - 18669648
HTP
1.00
 - Hamartin
0.68
 - low
T 1047 GSSSSSSELSTPEKPPHQRAG CDK1 14551205
LTP
0.03
 MOD_CDK_SPxK_1
 - -
0.91
 - low
S 1102 ARELFRNKSESQCDEDGMTSS - 17525332
HTP
1.00
 - -
0.77
 - low

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