Substrate: Rho/Rac guanine nucleotide exchange factor 2 (Stimulates guanine nucleotide exchange of Rac and Rho)
Seq-ID: Q92974 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-3295597   1433Z_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Rac guanyl-nucleotide exchange factor activity,
Rac GTPase binding,
microtubule binding,
zinc ion binding		 spindle,
cytosol,
ruffle membrane,
Golgi apparatus,
microtubule,
tight junction		 induction of apoptosis by extracellular signals,
cell division,
cell morphogenesis,
apoptosis,
actin filament organization,
intracellular protein transport,
negative regulation of microtubule depolymerization,
mitosis,
regulation of cell proliferation,
positive regulation of NF-kappaB transcription factor activity,
regulation of Rho protein signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 149 RGRSSLSLAKSVSTTNIAGHF - 18220336
HTP
1.00
 - -
0.40
 - low
S 151 RSSLSLAKSVSTTNIAGHFND - 18220336
HTP
1.00
 - -
0.38
 - low
T 152 SSLSLAKSVSTTNIAGHFNDE - 18220336
HTP
1.00
 - -
0.38
 - low
T 153 SLSLAKSVSTTNIAGHFNDES - 18220336
HTP
0.09
 - -
0.38
 - low
S 163 TNIAGHFNDESPLGLRRILSQ - 16565220
HTP
0.33
 - -
0.37
 - low
S 163 TNIAGHFNDESPLGLRRILSQ - 18220336
HTP
0.33
 - -
0.37
 - low
S 163 TNIAGHFNDESPLGLRRILSQ - 18669648
HTP
0.33
 - -
0.37
 - low
S 174 PLGLRRILSQSTDSLNMRNRT - 18669648
HTP
1.00
 - -
0.42
 - low
S 644 TLPRGLFRSESLESPRGERLL - 18088087
HTP
0.00
 - -
0.52
 - low
S 644 TLPRGLFRSESLESPRGERLL - 18669648
HTP
0.00
 - -
0.52
 - low
S 647 RGLFRSESLESPRGERLLQDA - 18669648
HTP
0.00
 - -
0.47
 - low
T 694 LPLEPDSGGNTSPGVTANGEA - 18669648
HTP
0.00
 - -
0.87
 - low
S 695 PLEPDSGGNTSPGVTANGEAR - 16565220
HTP
0.95
 - -
0.86
 - low
S 695 PLEPDSGGNTSPGVTANGEAR - 16964243
HTP
0.95
 - -
0.86
 - low
S 695 PLEPDSGGNTSPGVTANGEAR - 18669648
HTP
0.95
 - -
0.86
 - low
S 885 ARRPVDPRRRSSPQAMPCT   PAK1 14970201
LTP
0.00
 - -
0.83
 - low

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