Substrate: P2X purinoceptor 7 (Responsible fro ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecule )
Seq-ID: Q99572 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-7244554   ABL1_HUMAN
MINT-7249138   NCK1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
lipopolysaccharide binding,
protein homodimerization activity,
purinergic nucleotide receptor activity,
extracellular ATP-gated cation channel activity,
ATP binding,
receptor binding		 bleb,
cytoplasm,
integral to plasma membrane		 positive regulation of interleukin-1 beta secretion,
sensory perception of pain,
membrane depolarization,
regulation of killing of cells of another organism,
positive regulation of cytolysis,
positive regulation of calcium ion transport into cytosol,
bleb assembly,
regulation of sodium ion transport,
negative regulation of MAPKKK cascade,
positive regulation of cytoskeleton organization,
response to ATP,
negative regulation of bone resorption,
pore complex assembly,
cell surface receptor linked signaling pathway,
positive regulation of bone mineralization
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 343 LVVYIGSTLSYFGLAAVFIDF - 11707406
LTP
1.00
 - P2X_receptor
0.01
 - low

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