Substrate: MAP3K5 (Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.1. -) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1)
Seq-ID: Q99683 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16168   M3K3_HUMAN
MINT-18083   M3K2_HUMAN
MINT-18459   DAB2P_HUMAN
MINT-3391607   MP2K7_HUMAN
MINT-7263196   ARRB2_HUMAN
MINT-7263254   ARRB1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
magnesium ion binding,
protein homodimerization activity,
ATP binding,
caspase activator activity,
MAP kinase kinase kinase activity		 induction of apoptosis by extracellular signals,
apoptosis,
activation of JUN kinase activity,
interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 83 SSSATRGRGSSVGGGSRRTTV PKB_group 11154276
LTP
0.18
 MOD_PKB_1
 - -
0.61
 --
S 83 SSSATRGRGSSVGGGSRRTTV PKB_beta 11154276
LTP
0.18
 MOD_PKB_1
 - -
0.61
 --
S 83 SSSATRGRGSSVGGGSRRTTV PKB_group 14500571
LTP
0.18
 MOD_PKB_1
 - -
0.61
 --
T 838 RLAGINPCTETFTGTLQYMAP PDK-1 15755722
LTP
1.00
 - S_TKc
0.24
 2CLQ 86.30%
T 838 RLAGINPCTETFTGTLQYMAP - 11920685
LTP
1.00
 - S_TKc
0.24
 2CLQ 86.30%
S 966 AGSNEYLRSISLPVPVLVEDT MAP3K5 10411906
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.33
 --
S 1029 GIPDENFEDHSAPPSPEEKDS - 18088087
HTP
0.26
 - -
0.71
 --
S 1033 ENFEDHSAPPSPEEKDSGFFM - 15094778
LTP
1.00
 - -
0.61
 --
S 1033 ENFEDHSAPPSPEEKDSGFFM - 18088087
HTP
1.00
 - -
0.61
 --

Valid HTML 4.01 Transitional