Substrate: SH2-containing inositol 5-phosphatase (Enzyme: Phosphatase)
Seq-ID: Q9ES52 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19846   PLCG2_MOUSE
MINT-58734   SLAF1_MOUSE
MINT-59440   PLCG1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
inositol-polyphosphate 5-phosphatase activity,
PTB domain binding,
phosphatidylinositol trisphosphate phosphatase activity		 plasma membrane,
cytoplasm		 intracellular signaling pathway,
negative regulation of monocyte differentiation,
negative regulation of immune response,
negative regulation of signal transduction,
apoptosis,
determination of adult lifespan,
positive regulation of B cell differentiation,
negative regulation of neutrophil differentiation,
negative regulation of interleukin-6 biosynthetic process,
positive regulation of apoptosis,
positive regulation of erythrocyte differentiation,
negative regulation of bone resorption,
negative regulation of B cell proliferation,
negative regulation of osteoclast differentiation,
immunoglobulin mediated immune response
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 868 TSQGKMREKLYDFVKTERDES - 19144319
HTP
1.00
 - -
0.59
 - low
S 889 SGMKCLKNLTSHDPMRQWEPS - 19144319
HTP
0.91
 - -
0.60
 - low
Y 918 SSLNEMINPNYIGMGPFGQPL - 9099679
LTP
0.93
 - -
0.54
 - low
T 964 LGPGRGEGPPTPPSQPPLSPK - 19144319
HTP
0.16
 - -
0.95
 - low
S 972 PPTPPSQPPLSPKKFSSSTAN - 19144319
HTP
0.10
 - -
0.90
 - low
Y 1021 TKPEMFENPLYGSVSSFPKLV - 9099679
LTP
0.11
 - -
0.52
 - low

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