Substrate: Histone deacetylase 6 (Enzyme: Deacetylase)
Seq-ID: Q9UBN7 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-17225   DCTN1_HUMAN
MINT-49024   RELB_HUMAN
MINT-5206963   TBA4A_HUMAN
MINT-7247182   FYN_HUMAN
MINT-7680083   CYLD_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Hsp90 protein binding,
specific transcriptional repressor activity,
histone deacetylase activity,
histone deacetylase binding,
beta-catenin binding,
dynein complex binding,
microtubule binding,
tubulin deacetylase activity,
alpha-tubulin binding,
zinc ion binding,
actin binding,
polyubiquitin binding,
tau protein binding		 caveola,
cytosol,
microtubule associated complex,
aggresome,
perinuclear region of cytoplasm,
cell leading edge,
histone deacetylase complex		 aggresome assembly,
response to toxin,
negative regulation of proteolysis,
regulation of receptor activity,
positive regulation of apoptosis,
regulation of microtubule-based movement,
negative regulation of oxidoreductase activity,
lysosome localization,
regulation of androgen receptor signaling pathway,
positive regulation of receptor biosynthetic process,
macroautophagy,
negative regulation of hydrogen peroxide metabolic process,
Hsp90 deacetylation,
peptidyl-lysine deacetylation,
polyubiquitinated misfolded protein transport,
tubulin deacetylation,
positive regulation of epithelial cell migration,
misfolded or incompletely synthesized protein catabolic process,
cellular response to hydrogen peroxide,
transcription,
positive regulation of cellular chaperone-mediated protein complex assembly,
response to growth factor stimulus,
histone deacetylation,
positive regulation of signal transduction
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 22 RQRRSRQNPQSPPQDSSVTSK - 15302935
HTP
0.28
 - -
0.93
 - low
S 22 RQRRSRQNPQSPPQDSSVTSK - 16964243
HTP
0.28
 - -
0.93
 - low
T 30 PQSPPQDSSVTSKRNIKKGAV - 17287340
HTP
0.07
 - -
0.83
 - low

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