Substrate: Insulin receptor substrate 2 (Adaptor molecule)
Seq-ID: Q9Y4H2 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-18053   IGF1R_HUMAN
MINT-18199   INSR_HUMAN
MINT-50999   1433B_HUMAN
MINT-3295882   1433Z_HUMAN
MINT-3975441   1433S_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
signal transducer activity plasma membrane,
cytosol		 negative regulation of kinase activity,
positive regulation of insulin secretion,
positive regulation of B cell proliferation,
positive regulation of fatty acid beta-oxidation,
response to glucose stimulus,
lipid homeostasis,
positive regulation of glycogen biosynthetic process,
negative regulation of plasma membrane long-chain fatty acid transport,
negative regulation of B cell apoptosis,
insulin receptor signaling pathway,
positive regulation of glucose import,
glucose metabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 75 GSAPQPPRLEYYESEKKWRSK - 18083107
HTP
1.00
 - PH
0.64
 - medium
Y 184 SAGAAGAEDSYGLVAPATAAY - 18669648
HTP
1.00
 - -
0.26
 - medium
S 304 LKELFEFRPRSKSQSSGSSAT IKK_group 12351658
LTP
1.00
 - -
0.53
 - medium
S 306 ELFEFRPRSKSQSSGSSATHP IKK_group 12351658
LTP
1.00
 - -
0.58
 - medium
S 306 ELFEFRPRSKSQSSGSSATHP - 18669648
HTP
1.00
 - -
0.58
 - medium
S 308 FEFRPRSKSQSSGSSATHPIS - 18669648
HTP
1.00
 - -
0.64
 - medium
S 312 PRSKSQSSGSSATHPISVPGA - 18669648
HTP
0.02
 - -
0.76
 - medium
S 334 RHHHLVNLPPSQTGLVRRSRT - 17525332
HTP
1.00
 - -
0.67
 - medium
S 346 TGLVRRSRTDSLAATPPAAKC - 16964243
HTP
1.00
 - -
0.61
 - medium
S 346 TGLVRRSRTDSLAATPPAAKC - 18669648
HTP
1.00
 - -
0.61
 - medium
T 350 RRSRTDSLAATPPAAKCSSCR - 16964243
HTP
1.00
 - -
0.56
 - medium
T 350 RRSRTDSLAATPPAAKCSSCR - 18669648
HTP
1.00
 - -
0.56
 - medium
T 363 AAKCSSCRVRTASEGDGGAAA - 18669648
HTP
1.00
 - -
0.61
 - medium
S 365 KCSSCRVRTASEGDGGAAAGA - 18220336
HTP
1.00
 - -
0.60
 - medium
S 365 KCSSCRVRTASEGDGGAAAGA - 18669648
HTP
1.00
 - -
0.60
 - medium
S 384 GAAAAGARPVSVAGSPLSPGP IKK_group 12351658
LTP
1.00
 - -
0.74
 - medium
S 384 GAAAAGARPVSVAGSPLSPGP - 18669648
HTP
1.00
 - -
0.74
 - medium
S 388 AGARPVSVAGSPLSPGPVRAP IKK_group 12351658
LTP
1.00
 - -
0.78
 - medium
S 388 AGARPVSVAGSPLSPGPVRAP - 18088087
HTP
1.00
 - -
0.78
 - medium
S 388 AGARPVSVAGSPLSPGPVRAP - 18220336
HTP
1.00
 - -
0.78
 - medium
S 388 AGARPVSVAGSPLSPGPVRAP - 18669648
HTP
1.00
 - -
0.78
 - medium
S 391 RPVSVAGSPLSPGPVRAPLSR - 18088087
HTP
1.00
 - -
0.80
 - medium
S 391 RPVSVAGSPLSPGPVRAPLSR - 18220336
HTP
1.00
 - -
0.80
 - medium
S 391 RPVSVAGSPLSPGPVRAPLSR - 18669648
HTP
1.00
 - -
0.80
 - medium
S 518 GDLRAFCSHRSNTPESIAETP - 18669648
HTP
1.00
 - -
0.73
 - medium
T 520 LRAFCSHRSNTPESIAETPPA - 15302935
HTP
1.00
 - -
0.75
 - medium
T 520 LRAFCSHRSNTPESIAETPPA - 18669648
HTP
1.00
 - -
0.75
 - medium
S 523 FCSHRSNTPESIAETPPARDG - 18669648
HTP
1.00
 - -
0.84
 - medium
T 527 RSNTPESIAETPPARDGGGGG - 16964243
HTP
1.00
 - -
0.90
 - medium
T 527 RSNTPESIAETPPARDGGGGG - 18669648
HTP
1.00
 - -
0.90
 - medium
S 550 YGYMTMDRPLSHCGRSYRRVS - 18669648
HTP
0.08
 - -
0.49
 - medium
S 560 SHCGRSYRRVSGDAAQDLDRG - 18669648
HTP
0.13
 - -
0.63
 - medium
S 577 LDRGLRKRTYSLTTPARQRPV IKK_group 12351658
LTP
1.00
 - -
0.77
 - medium
S 577 LDRGLRKRTYSLTTPARQRPV - 16964243
HTP
1.00
 - -
0.77
 - medium
S 577 LDRGLRKRTYSLTTPARQRPV - 18220336
HTP
1.00
 - -
0.77
 - medium
S 577 LDRGLRKRTYSLTTPARQRPV - 18669648
HTP
1.00
 - -
0.77
 - medium
T 579 RGLRKRTYSLTTPARQRPVPQ - 18669648
HTP
0.20
 - -
0.79
 - medium
T 580 GLRKRTYSLTTPARQRPVPQP - 16964243
HTP
1.00
 - -
0.80
 - medium
T 580 GLRKRTYSLTTPARQRPVPQP - 18669648
HTP
1.00
 - -
0.80
 - medium
S 594 QRPVPQPSSASLDEYTLMRAT - 18669648
HTP
1.00
 - -
0.65
 - medium
S 608 YTLMRATFSGSAGRLCPSCPA - 18088087
HTP
0.07
 - -
0.38
 - medium
S 608 YTLMRATFSGSAGRLCPSCPA - 18669648
HTP
0.07
 - -
0.38
 - medium
S 620 GRLCPSCPASSPKVAYHPYPE - 18669648
HTP
1.00
 - -
0.44
 - medium
Y 653 SSSNLGADDGYMPMTPGAALA - 16497976
HTP
1.00
 PIK3R1 SH2 -
0.60
 - medium
Y 653 SSSNLGADDGYMPMTPGAALA - 18083107
HTP
1.00
 PIK3R1 SH2 -
0.60
 - medium
Y 675 SGSGSCRSDDYMPMSPASVSA - 16497976
HTP
1.00
 PIK3R1 SH2 -
0.59
 - medium
Y 675 SGSGSCRSDDYMPMSPASVSA - 18083107
HTP
1.00
 PIK3R1 SH2 -
0.59
 - medium
Y 675 SGSGSCRSDDYMPMSPASVSA - 18669648
HTP
1.00
 PIK3R1 SH2 -
0.59
 - medium
S 679 SCRSDDYMPMSPASVSAPKQI - 18669648
HTP
1.00
 - -
0.60
 - medium
T 713 PSAGPAGPAPTSAAGRTFPAS - 18220336
HTP
 - - -
0.69
 - medium
T 713 PSAGPAGPAPTSAAGRTFPAS - 18669648
HTP
 - - -
0.69
 - medium
S 714 SAGPAGPAPTSAAGRTFPASG - 18669648
HTP
 - - -
0.68
 - medium
S 730 FPASGGGYKASSPAESSPEDS - 18669648
HTP
0.10
 - -
0.71
 - medium
S 731 PASGGGYKASSPAESSPEDSG - 18669648
HTP
1.00
 - -
0.70
 - medium
S 735 GGYKASSPAESSPEDSGYMRM - 18669648
HTP
0.02
 - -
0.57
 - medium
S 736 GYKASSPAESSPEDSGYMRMW - 18669648
HTP
0.25
 - -
0.55
 - medium
Y 742 PAESSPEDSGYMRMWCGSKLS - 18083107
HTP
1.00
 PIK3R1 SH2 -
0.49
 - medium
S 770 LLPNGDYLNVSPSDAVTTGTP - 18220336
HTP
1.00
 - -
0.66
 - medium
S 770 LLPNGDYLNVSPSDAVTTGTP - 18669648
HTP
1.00
 - -
0.66
 - medium
S 772 PNGDYLNVSPSDAVTTGTPPD - 18220336
HTP
0.11
 - -
0.65
 - medium
S 772 PNGDYLNVSPSDAVTTGTPPD - 18669648
HTP
0.11
 - -
0.65
 - medium
T 777 LNVSPSDAVTTGTPPDFFSAA - 18669648
HTP
0.14
 - -
0.59
 - medium
T 779 VSPSDAVTTGTPPDFFSAALH - 18669648
HTP
0.29
 - -
0.63
 - medium
Y 823 PYTCGGDSDQYVLMSSPVGRI - 16497976
HTP
0.47
 PIK3R1 SH2 -
0.46
 - medium
Y 823 PYTCGGDSDQYVLMSSPVGRI - 18083107
HTP
0.47
 PIK3R1 SH2 -
0.46
 - medium
S 828 GDSDQYVLMSSPVGRILEEER - 18669648
HTP
0.25
 - -
0.57
 - medium
S 894 RGRAVRPTRLSLEGLPSLPSM - 18669648
HTP
1.00
 - -
0.71
 - medium
S 915 HEYPLPPEPKSPGEYINIDFG - 15302935
HTP
1.00
 - -
0.74
 - medium
S 915 HEYPLPPEPKSPGEYINIDFG - 18088087
HTP
1.00
 - -
0.74
 - medium
S 915 HEYPLPPEPKSPGEYINIDFG - 18220336
HTP
1.00
 - -
0.74
 - medium
S 915 HEYPLPPEPKSPGEYINIDFG - 18669648
HTP
1.00
 - -
0.74
 - medium
Y 919 LPPEPKSPGEYINIDFGEPGA - 18669648
HTP
1.00
 GRB2 SH2 -
0.77
 - medium
S 973 PGTSSDSRQRSPLSDYMNLDF - 18669648
HTP
0.39
 - -
0.84
 - medium
S 1100 PPKPEAARVASPTSGVKRLSL - 15302935
HTP
1.00
 - -
0.80
 - medium
S 1100 PPKPEAARVASPTSGVKRLSL - 16964243
HTP
1.00
 - -
0.80
 - medium
S 1100 PPKPEAARVASPTSGVKRLSL - 18088087
HTP
1.00
 - -
0.80
 - medium
S 1100 PPKPEAARVASPTSGVKRLSL - 18669648
HTP
1.00
 - -
0.80
 - medium
S 1103 PEAARVASPTSGVKRLSLMEQ - 18669648
HTP
0.26
 - -
0.76
 - medium
S 1109 ASPTSGVKRLSLMEQVSGVEA - 18669648
HTP
0.07
 - -
0.67
 - medium
S 1148 ADPQGGRRRHSSETFSSTTTV - 18669648
HTP
1.00
 - -
0.91
 - medium
S 1149 DPQGGRRRHSSETFSSTTTVT - 15364919
LTP
1.00
 - -
0.91
 - medium
S 1149 DPQGGRRRHSSETFSSTTTVT - 18669648
HTP
1.00
 - -
0.91
 - medium
T 1151 QGGRRRHSSETFSSTTTVTPV - 18669648
HTP
1.00
 - -
0.89
 - medium
T 1159 SETFSSTTTVTPVSPSFAHNP - 18669648
HTP
1.00
 - -
0.81
 - medium
S 1162 FSSTTTVTPVSPSFAHNPKRH - 18669648
HTP
0.21
 - -
0.84
 - medium
S 1164 STTTVTPVSPSFAHNPKRHNS - 18669648
HTP
1.00
 - -
0.85
 - medium
S 1174 SFAHNPKRHNSASVENVSLRK - 18669648
HTP
1.00
 - -
0.82
 - medium
S 1176 AHNPKRHNSASVENVSLRKSS - 18220336
HTP
1.00
 - -
0.84
 - medium
S 1176 AHNPKRHNSASVENVSLRKSS - 18669648
HTP
1.00
 - -
0.84
 - medium
S 1185 ASVENVSLRKSSEGGVGVGPG - 18669648
HTP
0.07
 - -
0.83
 - medium
T 1202 VGPGGGDEPPTSPRQLQPAPP - 18669648
HTP
 - - -
0.97
 - medium
S 1203 GPGGGDEPPTSPRQLQPAPPL - 15302935
HTP
 - - -
0.98
 - medium
S 1203 GPGGGDEPPTSPRQLQPAPPL - 18669648
HTP
 - - -
0.98
 - medium
S 1283 PPLPQPGDKSSWGRTRSLGGL - 18669648
HTP
0.07
 - -
0.84
 - medium

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