Substrate: Epo-R (Receptor for erythropoietin, a major activator of erythropoiesis)
Seq-ID: P19235 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-73504   PTN6_HUMAN
MINT-74896   PTN6_MOUSE
MINT-6794748   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
erythropoietin receptor activity extracellular region,
integral to plasma membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 368 PVGSEHAQDTYLVLDKWLLPR Lyn 10579919
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
STAT5 SH2;
SYK SH2		 -
0.32
 - low
Y 368 PVGSEHAQDTYLVLDKWLLPR JAK2 10579919
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
STAT5 SH2;
SYK SH2		 -
0.32
 - low
Y 426 PEGASAASFEYTILDPSSQLL - 10579919
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2		 -
0.45
 - low
Y 426 PEGASAASFEYTILDPSSQLL - 12027890
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2		 -
0.45
 - low
Y 426 PEGASAASFEYTILDPSSQLL - 12441334
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2		 -
0.45
 - low
Y 426 PEGASAASFEYTILDPSSQLL - 10660611
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2		 -
0.45
 - low
Y 454 ELPPTPPHLKYLYLVVSDSGI - 10579919
LTP
0.96
 CISH SH2;
PTPN6 SH2;
SOCS3 SH2;
STAT5 SH2;
SYK SH2		 -
0.37
 - low
Y 454 ELPPTPPHLKYLYLVVSDSGI - 12027890
LTP
0.96
 CISH SH2;
PTPN6 SH2;
SOCS3 SH2;
STAT5 SH2;
SYK SH2		 -
0.37
 - low
Y 456 PPTPPHLKYLYLVVSDSGIST - 10579919
LTP
1.00
 CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2		 -
0.36
 - low
Y 456 PPTPPHLKYLYLVVSDSGIST - 11443118
LTP
1.00
 CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2		 -
0.36
 - low
Y 456 PPTPPHLKYLYLVVSDSGIST - 12027890
LTP
1.00
 CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2		 -
0.36
 - low

Substrate: GH-R (Growth hormon receptor)
Seq-ID: P10912 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-6797534   DUS7_HUMAN
MINT-6797749   PTN2_HUMAN
MINT-6797775   PTN9_HUMAN
MINT-6797788   PTPRB_HUMAN
MINT-6797829   PTN1_HUMAN
MINT-6797890   PTN3_HUMAN
MINT-7250542   NCK1_HUMAN
MINT-7252318   P85A_HUMAN
MINT-7252594   PLCG1_HUMAN
MINT-7254526   CRK_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein homodimerization activity,
protein kinase binding,
peptide hormone binding,
growth factor binding,
proline-rich region binding		 growth hormone receptor complex,
integral to plasma membrane,
cell surface,
extracellular space		 valine metabolic process,
activation of JAK2 kinase activity,
oxaloacetate metabolic process,
creatinine metabolic process,
isoleucine metabolic process,
positive regulation of tyrosine phosphorylation of Stat3 protein,
taurine metabolic process,
positive regulation of tyrosine phosphorylation of Stat5 protein,
response to estradiol stimulus,
insulin-like growth factor receptor signaling pathway,
allantoin metabolic process,
fatty acid metabolic process,
positive regulation of multicellular organism growth,
response to cycloheximide,
citrate metabolic process,
activation of MAPK activity,
multicellular organismal metabolic process,
2-oxoglutarate metabolic process,
succinate metabolic process,
growth hormone receptor signaling pathway,
endocytosis,
creatine metabolic process,
receptor internalization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 487 NPSSLSNIDFYAQVSDITPAG JAK2 9121492
LTP
1.00
 CISH SH2;
GRB10 SH2;
SOCS2 SH2;
STAT3 SH2;
STAT5 SH2		 -
0.42
 - low

Valid HTML 4.01 Transitional