a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Bcr  GH-R  IGF1-R  Insulin R  EPHB1  EPHB2 

Substrate:	Bcr (Breakpoint cluster region protein)
Seq-ID:	P11274 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-69534   AT2B1_HUMAN MINT-69536   CLH1_HUMAN MINT-69537   CFTR_HUMAN MINT-69540   ZO2_HUMAN MINT-69542   RGS12_HUMAN MINT-4961172   AFAD_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process Rho guanyl-nucleotide exchange factor activity, protein serine/threonine kinase activity, ATP binding, GTPase activator activity intracellular protein amino acid phosphorylation, signal transduction, regulation of Rho protein signal transduction
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	246	SESSCGVDGDYEDAELNPRFL	Fes	8955135	LTP	1.00		ABL1 SH2; GRB10 SH2; GRB2 SH2	-	0.57	-	medium
Y	276	GSRPPWPPLEYQPYQSIYVGG	Fes	8955135	LTP	0.00		ABL1 SH2; GRB10 SH2; GRB2 SH2; SHC1 SH2; SHC_group SH2	-	0.58	-	medium
Y	279	PPWPPLEYQPYQSIYVGGMME	Fes	8955135	LTP	1.00		ABL1 SH2; GRB10 SH2; GRB2 SH2; SHC1 SH2; SHC_group SH2	-	0.58	-	medium
Y	283	PLEYQPYQSIYVGGMMEGEGK	Fes	8955135	LTP	1.00		ABL1 SH2; GRB10 SH2; GRB2 SH2; SHC1 SH2; SHC_group SH2	-	0.61	-	medium
Y	328	PRSFEDCGGGYTPDCSSNENL	-	9467953	LTP	0.58		GRB10 SH2	-	0.56	-	medium
Y	360	SSRVSPSPTTYRMFRDKSRSP	Abl	9467953	LTP	0.53		GRB10 SH2	-	0.77	-	medium
Y	436	ADGSFGTPPGYGCAADRAEEQ	-	16497976	HTP	0.81		GRB10 SH2	-	0.71	-	medium

Substrate:	GH-R (Growth hormon receptor)
Seq-ID:	P10912 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-6797534   DUS7_HUMAN MINT-6797749   PTN2_HUMAN MINT-6797775   PTN9_HUMAN MINT-6797788   PTPRB_HUMAN MINT-6797829   PTN1_HUMAN MINT-6797890   PTN3_HUMAN MINT-7250542   NCK1_HUMAN MINT-7252318   P85A_HUMAN MINT-7252594   PLCG1_HUMAN MINT-7254526   CRK_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein homodimerization activity, protein kinase binding, peptide hormone binding, growth factor binding, proline-rich region binding growth hormone receptor complex, integral to plasma membrane, cell surface, extracellular space valine metabolic process, activation of JAK2 kinase activity, oxaloacetate metabolic process, creatinine metabolic process, isoleucine metabolic process, positive regulation of tyrosine phosphorylation of Stat3 protein, taurine metabolic process, positive regulation of tyrosine phosphorylation of Stat5 protein, response to estradiol stimulus, insulin-like growth factor receptor signaling pathway, allantoin metabolic process, fatty acid metabolic process, positive regulation of multicellular organism growth, response to cycloheximide, citrate metabolic process, activation of MAPK activity, multicellular organismal metabolic process, 2-oxoglutarate metabolic process, succinate metabolic process, growth hormone receptor signaling pathway, endocytosis, creatine metabolic process, receptor internalization
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	487	NPSSLSNIDFYAQVSDITPAG	JAK2	9121492	LTP	1.00		CISH SH2; GRB10 SH2; SOCS2 SH2; STAT3 SH2; STAT5 SH2	-	0.42	-	low
Y	534	CQENFLMDNAYFCEADAKKCI	-	9121492	LTP	0.93		GRB10 SH2; STAT3 SH2; STAT5 SH2	-	0.16	-	low
Y	534	CQENFLMDNAYFCEADAKKCI	-	8647880	LTP	0.93		GRB10 SH2; STAT3 SH2; STAT5 SH2	-	0.16	-	low
Y	566	IQPSLNQEDIYITTESLTTAA	-	9121492	LTP	1.00		GRB10 SH2; STAT3 SH2; STAT5 SH2	-	0.47	-	low
Y	566	IQPSLNQEDIYITTESLTTAA	-	8647880	LTP	1.00		GRB10 SH2; STAT3 SH2; STAT5 SH2	-	0.47	-	low

Substrate:	IGF1-R (Receptor tyrosine kinase)
Seq-ID:	P08069 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-15644   GRB10_HUMAN MINT-18053   IRS2_HUMAN MINT-1774754   ARHGC_MOUSE MINT-1774976   ARHGC_HUMAN MINT-6800783   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process phosphoinositide 3-kinase binding, identical protein binding, insulin-like growth factor receptor activity, insulin binding, metal ion binding, insulin receptor binding, insulin receptor substrate binding, ATP binding, insulin-like growth factor I binding microsome, integral to plasma membrane positive regulation of DNA replication, positive regulation of cell proliferation, positive regulation of cell migration, anti-apoptosis, phosphoinositide 3-kinase cascade, phosphoinositide-mediated signaling, immune response, protein amino acid autophosphorylation, insulin receptor signaling pathway, protein tetramerization
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1346	LRASFDERQPYAHMNGGRKNE	IGF1R	8550552	LTP	1.00		Csk SH2; GRB10 SH2; PIK3R1 SH2; PTPN11 SH2	-	0.63	-	-

Substrate:	Insulin R (Receptor tyrosine kinase)
Seq-ID:	P06213 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-16516   GRB10_HUMAN MINT-16842   MD2L1_HUMAN MINT-18199   IRS2_HUMAN MINT-19010   IRS1_HUMAN MINT-73466   GRB10_MOUSE MINT-6793537   INSR_RAT MINT-6794075   IRS1_MOUSE MINT-6794090   INSR_MOUSE MINT-6794946   PTN1_HUMAN MINT-6795115   IRS1_RAT
GO-Terms:	[show] Molecular Function Cellular Component Biological Process insulin-like growth factor receptor binding, insulin binding, PTB domain binding, GTP binding, metal ion binding, insulin receptor substrate binding, ATP binding, insulin-like growth factor I binding, insulin receptor activity, SH2 domain binding, phosphoinositide 3-kinase binding, insulin-like growth factor II binding, receptor signaling protein tyrosine kinase activity microsome, caveola, insulin receptor complex, endosome membrane positive regulation of glycolysis, positive regulation of MAPKKK cascade, positive regulation of developmental growth, regulation of embryonic development, heart morphogenesis, positive regulation of cell migration, carbohydrate metabolic process, protein heterotetramerization, positive regulation of protein kinase B signaling cascade, protein amino acid autophosphorylation, activation of MAPK activity, positive regulation of glycogen biosynthetic process, positive regulation of mitosis, peptidyl-tyrosine phosphorylation, positive regulation of glucose import, positive regulation of respiratory burst, activation of protein kinase B activity, G-protein coupled receptor protein signaling pathway, positive regulation of DNA replication, positive regulation of protein amino acid phosphorylation, positive regulation of cell proliferation, glucose homeostasis, positive regulation of nitric oxide biosynthetic process, transformation of host cell by virus, regulation of gene-specific transcription
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	999	GPLYASSNPEYLSASDVFPCS	INSR	8662806	LTP	1.00		CRKL SH2; GRB10 SH2; IRS1 PTB; IRS2 PTB; RASA_group SH2; SHC1 PTB; SHC1 SH2; STAT5 SH2	-	0.11	-	-
Y	999	GPLYASSNPEYLSASDVFPCS	INSR	1658004	LTP	1.00		CRKL SH2; GRB10 SH2; IRS1 PTB; IRS2 PTB; RASA_group SH2; SHC1 PTB; SHC1 SH2; STAT5 SH2	-	0.11	-	-
Y	999	GPLYASSNPEYLSASDVFPCS	-	8393870	LTP	1.00		CRKL SH2; GRB10 SH2; IRS1 PTB; IRS2 PTB; RASA_group SH2; SHC1 PTB; SHC1 SH2; STAT5 SH2	-	0.11	-	-
Y	999	GPLYASSNPEYLSASDVFPCS	INSR	10340378	LTP	1.00		CRKL SH2; GRB10 SH2; IRS1 PTB; IRS2 PTB; RASA_group SH2; SHC1 PTB; SHC1 SH2; STAT5 SH2	-	0.11	-	-
Y	1185	IGDFGMTRDIYETDYYRKGGK	INSR	7806540	LTP	1.00		GRB10 SH2; GRB14 SH2; PTPN11 SH2; SH2B1 SH2; SH2B2 SH2	TyrKc	0.19	1IR3	100.87%
Y	1185	IGDFGMTRDIYETDYYRKGGK	-	18083107	HTP	1.00		GRB10 SH2; GRB14 SH2; PTPN11 SH2; SH2B1 SH2; SH2B2 SH2	TyrKc	0.19	1IR3	100.87%
Y	1189	GMTRDIYETDYYRKGGKGLLP	INSR	7806540	LTP	1.00		GRB10 SH2; GRB14 SH2; PTPN11 SH2; SH2B1 SH2; SH2B2 SH2	TyrKc	0.19	1IR3	67.69%
Y	1189	GMTRDIYETDYYRKGGKGLLP	-	9506989	LTP	1.00		GRB10 SH2; GRB14 SH2; PTPN11 SH2; SH2B1 SH2; SH2B2 SH2	TyrKc	0.19	1IR3	67.69%
Y	1189	GMTRDIYETDYYRKGGKGLLP	-	18083107	HTP	1.00		GRB10 SH2; GRB14 SH2; PTPN11 SH2; SH2B1 SH2; SH2B2 SH2	TyrKc	0.19	1IR3	67.69%
Y	1190	MTRDIYETDYYRKGGKGLLPV	INSR	7806540	LTP	1.00		GRB10 SH2; PTPN11 SH2; SH2B1 SH2	TyrKc	0.17	1IR3	44.54%
Y	1190	MTRDIYETDYYRKGGKGLLPV	-	9506989	LTP	1.00		GRB10 SH2; PTPN11 SH2; SH2B1 SH2	TyrKc	0.17	1IR3	44.54%
Y	1190	MTRDIYETDYYRKGGKGLLPV	-	18083107	HTP	1.00		GRB10 SH2; PTPN11 SH2; SH2B1 SH2	TyrKc	0.17	1IR3	44.54%
Y	1355	GGSSLGFKRSYEEHIPYTHMN	INSR	1321605	LTP	0.85		GRB10 SH2; PIK3R1 SH2	-	0.50	-	-
Y	1361	FKRSYEEHIPYTHMNGGKKNG	INSR	1321605	LTP	0.95		Csk SH2; GRB10 SH2; PIK3R1 SH2; PTPN11 SH2; SHC1 SH2	-	0.54	-	-

Substrate:	EPHB1 (Receptor for member of the ephrinB family)
Seq-ID:	Q07494 [Gallus gallus]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process ephrin receptor activity, ATP binding, protein binding integral to plasma membrane protein amino acid phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	928	DWLSAVKMSQYRDNFLSAGFT	-	12223469	LTP	1.00		GRB10 SH2; GRB7 SH2	SAM	0.15	-	low
Y	928	DWLSAVKMSQYRDNFLSAGFT	-	7731717	LTP	1.00		GRB10 SH2; GRB7 SH2	SAM	0.15	-	low

Substrate:	EPHB2 (Receptor for member of the ephrinB family)
Seq-ID:	P54763 [Mus musculus]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	MINT-3388251   EPHA4_MOUSE
GO-Terms:	[show] Molecular Function Cellular Component Biological Process transmembrane-ephrin receptor activity, axon guidance receptor activity, ATP binding, receptor binding neuronal cell body, integral to plasma membrane, synapse negative regulation of axonogenesis, retinal ganglion cell axon guidance, positive regulation of long-term neuronal synaptic plasticity, ephrin receptor signaling pathway, learning, camera-type eye morphogenesis, central nervous system projection neuron axonogenesis, peptidyl-tyrosine phosphorylation, optic nerve morphogenesis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	938	EWLEAIKMGQYKESFANAGFT	-	8798570	LTP	0.93		GRB10 SH2	SAM	0.17	-	-