a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

Substrate:	Insulin R (Receptor tyrosine kinase)
Seq-ID:	P06213 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-16516   GRB10_HUMAN MINT-16842   MD2L1_HUMAN MINT-18199   IRS2_HUMAN MINT-19010   IRS1_HUMAN MINT-73466   GRB10_MOUSE MINT-6793537   INSR_RAT MINT-6794075   IRS1_MOUSE MINT-6794090   INSR_MOUSE MINT-6794946   PTN1_HUMAN MINT-6795115   IRS1_RAT
GO-Terms:	[show] Molecular Function Cellular Component Biological Process insulin-like growth factor receptor binding, insulin binding, PTB domain binding, GTP binding, metal ion binding, insulin receptor substrate binding, ATP binding, insulin-like growth factor I binding, insulin receptor activity, SH2 domain binding, phosphoinositide 3-kinase binding, insulin-like growth factor II binding, receptor signaling protein tyrosine kinase activity microsome, caveola, insulin receptor complex, endosome membrane positive regulation of glycolysis, positive regulation of MAPKKK cascade, positive regulation of developmental growth, regulation of embryonic development, heart morphogenesis, positive regulation of cell migration, carbohydrate metabolic process, protein heterotetramerization, positive regulation of protein kinase B signaling cascade, protein amino acid autophosphorylation, activation of MAPK activity, positive regulation of glycogen biosynthetic process, positive regulation of mitosis, peptidyl-tyrosine phosphorylation, positive regulation of glucose import, positive regulation of respiratory burst, activation of protein kinase B activity, G-protein coupled receptor protein signaling pathway, positive regulation of DNA replication, positive regulation of protein amino acid phosphorylation, positive regulation of cell proliferation, glucose homeostasis, positive regulation of nitric oxide biosynthetic process, transformation of host cell by virus, regulation of gene-specific transcription
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1185	IGDFGMTRDIYETDYYRKGGK	INSR	7806540	LTP	1.00		GRB10 SH2; GRB14 SH2; PTPN11 SH2; SH2B1 SH2; SH2B2 SH2	TyrKc	0.19	1IR3	100.87%
Y	1185	IGDFGMTRDIYETDYYRKGGK	-	18083107	HTP	1.00		GRB10 SH2; GRB14 SH2; PTPN11 SH2; SH2B1 SH2; SH2B2 SH2	TyrKc	0.19	1IR3	100.87%
Y	1189	GMTRDIYETDYYRKGGKGLLP	INSR	7806540	LTP	1.00		GRB10 SH2; GRB14 SH2; PTPN11 SH2; SH2B1 SH2; SH2B2 SH2	TyrKc	0.19	1IR3	67.69%
Y	1189	GMTRDIYETDYYRKGGKGLLP	-	9506989	LTP	1.00		GRB10 SH2; GRB14 SH2; PTPN11 SH2; SH2B1 SH2; SH2B2 SH2	TyrKc	0.19	1IR3	67.69%
Y	1189	GMTRDIYETDYYRKGGKGLLP	-	18083107	HTP	1.00		GRB10 SH2; GRB14 SH2; PTPN11 SH2; SH2B1 SH2; SH2B2 SH2	TyrKc	0.19	1IR3	67.69%

Substrate:	TIE2 (TEK) (PTK receptor for angiopoietin 1)
Seq-ID:	Q02763 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process transmembrane receptor protein tyrosine kinase activity, ATP binding, protein binding basolateral plasma membrane, integral to plasma membrane, cell surface, microvillus, apical plasma membrane, membrane raft positive regulation of ERK1 and ERK2 cascade, protein amino acid phosphorylation, protein oligomerization, cell-cell signaling, positive regulation of protein kinase B signaling cascade, regulation of cell proliferation, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1108	ERKTYVNTTLYEKFTYAGIDC	TIE2	10521483	LTP	0.08		DOK_group PTB; GRB14 SH2; PIK3R1 SH2	-	0.11	1FVR	76.42%
Y	1108	ERKTYVNTTLYEKFTYAGIDC	TIE2	12665569	LTP	0.08		DOK_group PTB; GRB14 SH2; PIK3R1 SH2	-	0.11	1FVR	76.42%