Substrate: Insulin R (Receptor tyrosine kinase)
Seq-ID: P06213 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16516   GRB10_HUMAN
MINT-16842   MD2L1_HUMAN
MINT-18199   IRS2_HUMAN
MINT-19010   IRS1_HUMAN
MINT-73466   GRB10_MOUSE
MINT-6793537   INSR_RAT
MINT-6794075   IRS1_MOUSE
MINT-6794090   INSR_MOUSE
MINT-6794946   PTN1_HUMAN
MINT-6795115   IRS1_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
insulin-like growth factor receptor binding,
insulin binding,
PTB domain binding,
GTP binding,
metal ion binding,
insulin receptor substrate binding,
ATP binding,
insulin-like growth factor I binding,
insulin receptor activity,
SH2 domain binding,
phosphoinositide 3-kinase binding,
insulin-like growth factor II binding,
receptor signaling protein tyrosine kinase activity		 microsome,
caveola,
insulin receptor complex,
endosome membrane		 positive regulation of glycolysis,
positive regulation of MAPKKK cascade,
positive regulation of developmental growth,
regulation of embryonic development,
heart morphogenesis,
positive regulation of cell migration,
carbohydrate metabolic process,
protein heterotetramerization,
positive regulation of protein kinase B signaling cascade,
protein amino acid autophosphorylation,
activation of MAPK activity,
positive regulation of glycogen biosynthetic process,
positive regulation of mitosis,
peptidyl-tyrosine phosphorylation,
positive regulation of glucose import,
positive regulation of respiratory burst,
activation of protein kinase B activity,
G-protein coupled receptor protein signaling pathway,
positive regulation of DNA replication,
positive regulation of protein amino acid phosphorylation,
positive regulation of cell proliferation,
glucose homeostasis,
positive regulation of nitric oxide biosynthetic process,
transformation of host cell by virus,
regulation of gene-specific transcription
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 999 GPLYASSNPEYLSASDVFPCS INSR 8662806
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 999 GPLYASSNPEYLSASDVFPCS INSR 1658004
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 999 GPLYASSNPEYLSASDVFPCS - 8393870
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 999 GPLYASSNPEYLSASDVFPCS INSR 10340378
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --

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