a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

Substrate:	CD28 (Involved in T cell activation)
Seq-ID:	P10747 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process identical protein binding, SH3/SH2 adaptor activity, coreceptor activity external side of plasma membrane, cytosol, integral to plasma membrane regulatory T cell differentiation, humoral immune response, positive regulation of anti-apoptosis, regulation of defense response to virus by virus, positive regulation of interleukin-2 biosynthetic process, positive regulation of viral genome replication, cell surface receptor linked signaling pathway, cytokine biosynthetic process, positive regulation of mitosis, positive regulation of T cell proliferation, positive regulation of translation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	191	SKRSRLLHSDYMNMTPRRPGP	Lck	8992971	LTP	0.95		GRAP2 SH2; GRB2 SH2; ITK SH2; PIK3R1 SH2	-	0.44	-	medium
Y	191	SKRSRLLHSDYMNMTPRRPGP	ITK	8992971	LTP	0.95		GRAP2 SH2; GRB2 SH2; ITK SH2; PIK3R1 SH2	-	0.44	-	medium
Y	191	SKRSRLLHSDYMNMTPRRPGP	-	16094384	HTP	0.95		GRAP2 SH2; GRB2 SH2; ITK SH2; PIK3R1 SH2	-	0.44	-	medium

Substrate:	SLP-76 (Adaptor molecule; involved in T cell AG receptor mediate signaling)
Seq-ID:	Q13094 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-15244   FYB_HUMAN MINT-16513   SHC1_HUMAN MINT-16846   CBL_HUMAN MINT-17488   FCGR1_HUMAN MINT-59471   ITK_MOUSE MINT-59473   ITK_HUMAN MINT-59474   LCK_HUMAN MINT-2837400   PLCG1_BOVIN MINT-4302560   STAM1_HUMAN MINT-4302608   STAM2_HUMAN MINT-7041321   GRAP2_HUMAN MINT-7306527   NCK1_HUMAN MINT-7306585   SRC_CHICK MINT-7306598   SRC_HUMAN MINT-7306611   FYN_HUMAN MINT-7306624   P85A_HUMAN MINT-7306637   PLCG1_HUMAN MINT-7306657   GRB2_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein binding cytosol immune response, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	113	GGWSSFEEDDYESPNDDQDGE	-	8892604	LTP	0.99		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.92	-	medium
Y	113	GGWSSFEEDDYESPNDDQDGE	ZAP70	9047237	LTP	0.99		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.92	-	medium
Y	113	GGWSSFEEDDYESPNDDQDGE	SYK	15388330	LTP	0.99		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.92	-	medium
Y	113	GGWSSFEEDDYESPNDDQDGE	ZAP70	12817019	LTP	0.99		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.92	-	medium
Y	113	GGWSSFEEDDYESPNDDQDGE	Lck	8702662	LTP	0.99		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.92	-	medium
Y	113	GGWSSFEEDDYESPNDDQDGE	ZAP70	8702662	LTP	0.99		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.92	-	medium
Y	128	DDQDGEDDGDYESPNEEEEAP	-	8892604	LTP	0.30		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.98	-	medium
Y	128	DDQDGEDDGDYESPNEEEEAP	ZAP70	9047237	LTP	0.30		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.98	-	medium
Y	128	DDQDGEDDGDYESPNEEEEAP	SYK	15388330	LTP	0.30		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.98	-	medium
Y	128	DDQDGEDDGDYESPNEEEEAP	ZAP70	12817019	LTP	0.30		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.98	-	medium
Y	128	DDQDGEDDGDYESPNEEEEAP	Lck	8702662	LTP	0.30		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.98	-	medium
Y	128	DDQDGEDDGDYESPNEEEEAP	ZAP70	8702662	LTP	0.30		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.98	-	medium
Y	145	EEAPVEDDADYEPPPSNDEEA	TXK	8892604	LTP	1.00		ITK SH2; NCK SH2; PTPN6 SH2; VAV1 SH2	-	0.97	-	medium
Y	145	EEAPVEDDADYEPPPSNDEEA	ZAP70	8892604	LTP	1.00		ITK SH2; NCK SH2; PTPN6 SH2; VAV1 SH2	-	0.97	-	medium