List of substrates found:

VEGFR-1  VEGFR-2  SH3 domain-binding protein 2  Epo-R  PLC gamma 2  CD19 


Substrate: VEGFR-1 (Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity.)
Seq-ID: P17948 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-6177086   LDLR_HUMAN
MINT-6539646   CBL_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
vascular endothelial growth factor receptor activity,
ATP binding,
growth factor binding		 cytoplasm,
integral to plasma membrane,
extracellular space		 positive regulation of vascular endothelial growth factor receptor signaling pathway,
female pregnancy,
peptidyl-tyrosine phosphorylation,
cell differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 794 KRSSSEIKTDYLSIIMDPDEV - 11741094
LTP
0.97
 PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2		 -
0.30
 - low
Y 794 KRSSSEIKTDYLSIIMDPDEV - 9398617
LTP
0.97
 PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2		 -
0.30
 - low
Y 1169 QANVQQDGKDYIPINAILTGN - 11513746
LTP
1.00
 PIK3R1 SH2;
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2		 -
0.30
 - low
Y 1169 QANVQQDGKDYIPINAILTGN - 9299537
LTP
1.00
 PIK3R1 SH2;
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2		 -
0.30
 - low

Substrate: VEGFR-2 (Receptor tyrosine kinase)
Seq-ID: P35968 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-49634   CADH5_HUMAN
MINT-49637   SHC1_HUMAN
MINT-2834292   NRP1_HUMAN
MINT-3381238   GRB2_HUMAN
MINT-3381278   NCK1_HUMAN
MINT-3381335   FYN_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Hsp90 protein binding,
vascular endothelial growth factor receptor activity,
receptor signaling protein tyrosine kinase activity,
ATP binding,
growth factor binding,
integrin binding		 integral to plasma membrane positive regulation of positive chemotaxis,
protein amino acid phosphorylation,
positive regulation of endothelial cell proliferation,
angiogenesis,
regulation of cell shape,
interspecies interaction between organisms,
positive regulation of endothelial cell migration,
positive regulation of focal adhesion assembly
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 801 RANGGELKTGYLSIVMDPDEL - 11741094
LTP
1.00
 PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2		 -
0.23
 --
Y 1175 QANAQQDGKDYIVLPISETLS KDR 10579917
LTP
1.00
 PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2		 -
0.41
 --
Y 1175 QANAQQDGKDYIVLPISETLS KDR 11387210
LTP
1.00
 PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2		 -
0.41
 --
Y 1175 QANAQQDGKDYIVLPISETLS - 10749680
LTP
1.00
 PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2		 -
0.41
 --
Y 1175 QANAQQDGKDYIVLPISETLS - 14532277
LTP
1.00
 PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2		 -
0.41
 --

Substrate: SH3 domain-binding protein 2 (Adaptor molecule)
Seq-ID: P78314 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-17097   1433T_HUMAN
MINT-74724   ERBB2_HUMAN
MINT-4549720   VAV_HUMAN
MINT-4563345   DBNL_HUMAN
MINT-4563367   SH3K1_HUMAN
MINT-7301276   VAV2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
SH3/SH2 adaptor activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 183 DYEHDDEDDSYLEPDSPEPGR - 11390470
LTP
1.00
 PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV2 SH2;
VAV_group SH2		 -
0.89
 - medium

Substrate: Epo-R (Receptor for erythropoietin, a major activator of erythropoiesis)
Seq-ID: P19235 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-73504   PTN6_HUMAN
MINT-74896   PTN6_MOUSE
MINT-6794748   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
erythropoietin receptor activity extracellular region,
integral to plasma membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 368 PVGSEHAQDTYLVLDKWLLPR Lyn 10579919
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
STAT5 SH2;
SYK SH2		 -
0.32
 - low
Y 368 PVGSEHAQDTYLVLDKWLLPR JAK2 10579919
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
STAT5 SH2;
SYK SH2		 -
0.32
 - low
Y 426 PEGASAASFEYTILDPSSQLL - 10579919
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2		 -
0.45
 - low
Y 426 PEGASAASFEYTILDPSSQLL - 12027890
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2		 -
0.45
 - low
Y 426 PEGASAASFEYTILDPSSQLL - 12441334
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2		 -
0.45
 - low
Y 426 PEGASAASFEYTILDPSSQLL - 10660611
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2		 -
0.45
 - low
Y 456 PPTPPHLKYLYLVVSDSGIST - 10579919
LTP
1.00
 CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2		 -
0.36
 - low
Y 456 PPTPPHLKYLYLVVSDSGIST - 11443118
LTP
1.00
 CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2		 -
0.36
 - low
Y 456 PPTPPHLKYLYLVVSDSGIST - 12027890
LTP
1.00
 CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2		 -
0.36
 - low
Y 504 IPAAEPLPPSYVACS       - 10579919
LTP
0.67
 INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2		 -
0.34
 - low
Y 504 IPAAEPLPPSYVACS       - 7559499
LTP
0.67
 INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2		 -
0.34
 - low
Y 504 IPAAEPLPPSYVACS       - 9573010
LTP
0.67
 INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2		 -
0.34
 - low

Substrate: PLC gamma 2 (Involved in transmembrane signaling)
Seq-ID: P16885 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-60791   Z512B_HUMAN
MINT-74685   EGFR_HUMAN
MINT-74686   ERBB2_HUMAN
MINT-7252126   P85A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide phospholipase C activity,
signal transducer activity,
protein binding		 plasma membrane phospholipid catabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 753 YNMERDINSLYDVSRMYVDPS - 11507089
LTP
0.37
 PLCG2 SH2 -
0.26
 - medium
Y 753 YNMERDINSLYDVSRMYVDPS Lck 11606584
LTP
0.37
 PLCG2 SH2 -
0.26
 - medium
Y 753 YNMERDINSLYDVSRMYVDPS SRC 11606584
LTP
0.37
 PLCG2 SH2 -
0.26
 - medium
Y 753 YNMERDINSLYDVSRMYVDPS BTK 11606584
LTP
0.37
 PLCG2 SH2 -
0.26
 - medium
Y 753 YNMERDINSLYDVSRMYVDPS Lck 12181444
LTP
0.37
 PLCG2 SH2 -
0.26
 - medium
Y 753 YNMERDINSLYDVSRMYVDPS - 15144186
HTP
0.37
 PLCG2 SH2 -
0.26
 - medium
Y 759 INSLYDVSRMYVDPSEINPSM - 11507089
LTP
0.98
 PLCG2 SH2 -
0.33
 - medium
Y 759 INSLYDVSRMYVDPSEINPSM Lck 11606584
LTP
0.98
 PLCG2 SH2 -
0.33
 - medium
Y 759 INSLYDVSRMYVDPSEINPSM SRC 11606584
LTP
0.98
 PLCG2 SH2 -
0.33
 - medium
Y 759 INSLYDVSRMYVDPSEINPSM BTK 11606584
LTP
0.98
 PLCG2 SH2 -
0.33
 - medium
Y 759 INSLYDVSRMYVDPSEINPSM Lck 12181444
LTP
0.98
 PLCG2 SH2 -
0.33
 - medium
Y 759 INSLYDVSRMYVDPSEINPSM BTK 14656219
LTP
0.98
 PLCG2 SH2 -
0.33
 - medium

Substrate: CD19 (Antigen of human B-lymphocytes)
Seq-ID: P15391 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor signaling protein activity,
protein binding		 integral to plasma membrane cellular defense response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 409 VGPEEEEGEGYEEPDSEEDSE - 10706702
LTP
1.00
 PLCG2 SH2;
VAV1 SH2;
VAV2 SH2;
VAV_group SH2		 -
0.97
 - medium
Y 439 QDQLSQDGSGYENPEDEPLGP - 10706702
LTP
1.00
 PLCG2 SH2;
VAV_group SH2		 -
0.97
 - medium

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