List of substrates found:

VEGFR-1  VEGFR-2  SH3 domain-binding protein 2  Epo-R  PLC gamma 2  CD19 


Substrate: VEGFR-1 (Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity.)
Seq-ID: P17948 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 794 KRSSSEIKTDYLSIIMDPDEV - 11741094
LTP
0.97
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2
-
0.30
- low
Y 794 KRSSSEIKTDYLSIIMDPDEV - 9398617
LTP
0.97
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2
-
0.30
- low
Y 1169 QANVQQDGKDYIPINAILTGN - 11513746
LTP
1.00
PIK3R1 SH2;
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2
-
0.30
- low
Y 1169 QANVQQDGKDYIPINAILTGN - 9299537
LTP
1.00
PIK3R1 SH2;
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2
-
0.30
- low

Substrate: VEGFR-2 (Receptor tyrosine kinase)
Seq-ID: P35968 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 801 RANGGELKTGYLSIVMDPDEL - 11741094
LTP
1.00
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2
-
0.23
--
Y 1175 QANAQQDGKDYIVLPISETLS KDR 10579917
LTP
1.00
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2
-
0.41
--
Y 1175 QANAQQDGKDYIVLPISETLS KDR 11387210
LTP
1.00
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2
-
0.41
--
Y 1175 QANAQQDGKDYIVLPISETLS - 10749680
LTP
1.00
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2
-
0.41
--
Y 1175 QANAQQDGKDYIVLPISETLS - 14532277
LTP
1.00
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2
-
0.41
--

Substrate: SH3 domain-binding protein 2 (Adaptor molecule)
Seq-ID: P78314 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
SH3/SH2 adaptor activity
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 183 DYEHDDEDDSYLEPDSPEPGR - 11390470
LTP
1.00
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV2 SH2;
VAV_group SH2
-
0.89
- medium

Substrate: Epo-R (Receptor for erythropoietin, a major activator of erythropoiesis)
Seq-ID: P19235 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
erythropoietin receptor activity extracellular region,
integral to plasma membrane
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 368 PVGSEHAQDTYLVLDKWLLPR Lyn 10579919
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
STAT5 SH2;
SYK SH2
-
0.32
- low
Y 368 PVGSEHAQDTYLVLDKWLLPR JAK2 10579919
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
STAT5 SH2;
SYK SH2
-
0.32
- low
Y 426 PEGASAASFEYTILDPSSQLL - 10579919
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 426 PEGASAASFEYTILDPSSQLL - 12027890
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 426 PEGASAASFEYTILDPSSQLL - 12441334
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 426 PEGASAASFEYTILDPSSQLL - 10660611
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 456 PPTPPHLKYLYLVVSDSGIST - 10579919
LTP
1.00
CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2
-
0.36
- low
Y 456 PPTPPHLKYLYLVVSDSGIST - 11443118
LTP
1.00
CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2
-
0.36
- low
Y 456 PPTPPHLKYLYLVVSDSGIST - 12027890
LTP
1.00
CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2
-
0.36
- low
Y 504 IPAAEPLPPSYVACS       - 10579919
LTP
0.67
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2
-
0.34
- low
Y 504 IPAAEPLPPSYVACS       - 7559499
LTP
0.67
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2
-
0.34
- low
Y 504 IPAAEPLPPSYVACS       - 9573010
LTP
0.67
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2
-
0.34
- low

Substrate: PLC gamma 2 (Involved in transmembrane signaling)
Seq-ID: P16885 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 753 YNMERDINSLYDVSRMYVDPS - 11507089
LTP
0.37
PLCG2 SH2 -
0.26
- medium
Y 753 YNMERDINSLYDVSRMYVDPS Lck 11606584
LTP
0.37
PLCG2 SH2 -
0.26
- medium
Y 753 YNMERDINSLYDVSRMYVDPS SRC 11606584
LTP
0.37
PLCG2 SH2 -
0.26
- medium
Y 753 YNMERDINSLYDVSRMYVDPS BTK 11606584
LTP
0.37
PLCG2 SH2 -
0.26
- medium
Y 753 YNMERDINSLYDVSRMYVDPS Lck 12181444
LTP
0.37
PLCG2 SH2 -
0.26
- medium
Y 753 YNMERDINSLYDVSRMYVDPS - 15144186
HTP
0.37
PLCG2 SH2 -
0.26
- medium
Y 759 INSLYDVSRMYVDPSEINPSM - 11507089
LTP
0.98
PLCG2 SH2 -
0.33
- medium
Y 759 INSLYDVSRMYVDPSEINPSM Lck 11606584
LTP
0.98
PLCG2 SH2 -
0.33
- medium
Y 759 INSLYDVSRMYVDPSEINPSM SRC 11606584
LTP
0.98
PLCG2 SH2 -
0.33
- medium
Y 759 INSLYDVSRMYVDPSEINPSM BTK 11606584
LTP
0.98
PLCG2 SH2 -
0.33
- medium
Y 759 INSLYDVSRMYVDPSEINPSM Lck 12181444
LTP
0.98
PLCG2 SH2 -
0.33
- medium
Y 759 INSLYDVSRMYVDPSEINPSM BTK 14656219
LTP
0.98
PLCG2 SH2 -
0.33
- medium

Substrate: CD19 (Antigen of human B-lymphocytes)
Seq-ID: P15391 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 409 VGPEEEEGEGYEEPDSEEDSE - 10706702
LTP
1.00
PLCG2 SH2;
VAV1 SH2;
VAV2 SH2;
VAV_group SH2
-
0.97
- medium
Y 439 QDQLSQDGSGYENPEDEPLGP - 10706702
LTP
1.00
PLCG2 SH2;
VAV_group SH2
-
0.97
- medium


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