Substrate: IL-2R beta (Cytokin receptor)
Seq-ID: P14784 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
interleukin-2 receptor activity external side of plasma membrane,
integral to plasma membrane		 protein complex assembly,
positive regulation of survival gene product expression,
interspecies interaction between organisms
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 418 LQPLSGEDDAYCTFPSRDDLL Lck 10214954
LTP
1.00
 SHB SH2;
STAT5 SH2		 -
0.55
 - medium
Y 536 NARLPLNTDAYLSLQELQGQD Lck 10214954
LTP
1.00
 SHB SH2;
STAT5 SH2		 -
0.71
 - medium

Substrate: VEGFR-2 (Receptor tyrosine kinase)
Seq-ID: P35968 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-49634   CADH5_HUMAN
MINT-49637   SHC1_HUMAN
MINT-2834292   NRP1_HUMAN
MINT-3381238   GRB2_HUMAN
MINT-3381278   NCK1_HUMAN
MINT-3381335   FYN_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Hsp90 protein binding,
vascular endothelial growth factor receptor activity,
receptor signaling protein tyrosine kinase activity,
ATP binding,
growth factor binding,
integrin binding		 integral to plasma membrane positive regulation of positive chemotaxis,
protein amino acid phosphorylation,
positive regulation of endothelial cell proliferation,
angiogenesis,
regulation of cell shape,
interspecies interaction between organisms,
positive regulation of endothelial cell migration,
positive regulation of focal adhesion assembly
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1175 QANAQQDGKDYIVLPISETLS KDR 10579917
LTP
1.00
 PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2		 -
0.41
 --
Y 1175 QANAQQDGKDYIVLPISETLS KDR 11387210
LTP
1.00
 PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2		 -
0.41
 --
Y 1175 QANAQQDGKDYIVLPISETLS - 10749680
LTP
1.00
 PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2		 -
0.41
 --
Y 1175 QANAQQDGKDYIVLPISETLS - 14532277
LTP
1.00
 PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2		 -
0.41
 --

Substrate: PDGF-R alpha (Receptor tyrosine kinase)
Seq-ID: P16234 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
platelet-derived growth factor alpha-receptor activity,
vascular endothelial growth factor receptor activity,
platelet-derived growth factor binding,
protein homodimerization activity,
platelet-derived growth factor receptor binding,
ATP binding		 integral to plasma membrane positive regulation of DNA replication,
positive regulation of fibroblast proliferation,
cell activation,
positive regulation of cell migration,
protein amino acid autophosphorylation,
peptidyl-tyrosine phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 720 LNPADESTRSYVILSFENNGD - 11818394
LTP
0.21
 PTPN11 SH2;
SHB SH2		 TyrKc
0.29
 - medium

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