Substrate: IL-6R (gp130) (gp130 is shared by members of the IL-6 family)
Seq-ID: P40189 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ciliary neurotrophic factor receptor activity,
protein homodimerization activity,
interleukin-27 receptor activity,
ciliary neurotrophic factor receptor binding		 extracellular region,
oncostatin-M receptor complex,
interleukin-6 receptor complex,
extracellular space,
ciliary neurotrophic factor receptor complex		 positive regulation vascular endothelial growth factor production,
positive regulation of tyrosine phosphorylation of Stat3 protein,
positive regulation of anti-apoptosis,
leukemia inhibitory factor signaling pathway,
response to cytokine stimulus,
negative regulation of interleukin-6-mediated signaling pathway,
positive regulation of tyrosine phosphorylation of Stat1 protein,
positive regulation of adaptive immune response,
ciliary neurotrophic factor-mediated signaling pathway,
positive regulation of T cell proliferation,
positive regulation of osteoblast differentiation,
interleukin-27-mediated signaling pathway,
positive regulation of acute inflammatory response,
positive regulation of cardiac muscle hypertrophy
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 759 SSQNTSSTVQYSTVVHSGYRH - 8934572
LTP
1.00
 PTPN11 SH2;
SOCS3 SH2;
STAT5 SH2		 -
0.61
 - medium
Y 759 SSQNTSSTVQYSTVVHSGYRH - 9505191
LTP
1.00
 PTPN11 SH2;
SOCS3 SH2;
STAT5 SH2		 -
0.61
 - medium

Substrate: JAK2 (Cytoplasmic tyrosine kinase)
Seq-ID: O60674 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13705   BRCA1_HUMAN
MINT-61281   G3BP1_HUMAN
MINT-74562   EGFR_HUMAN
MINT-74563   ERBB3_HUMAN
MINT-6764602   PTN1_HUMAN
MINT-7250518   NCK1_HUMAN
MINT-7251766   P85A_HUMAN
MINT-7252666   PLCG1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
histone binding,
Janus kinase activity,
histone kinase activity (H3-Y41 specific),
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
growth hormone receptor binding,
SH2 domain binding		 cytoskeleton,
endomembrane system		 activation of JAK2 kinase activity,
cytokine-mediated signaling pathway,
cellular component movement,
mesoderm development,
positive regulation of tyrosine phosphorylation of Stat3 protein,
positive regulation of tyrosine phosphorylation of Stat5 protein,
erythrocyte differentiation,
protein amino acid autophosphorylation,
JAK-STAT cascade involved in growth hormone signaling pathway,
response to antibiotic
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1007 LTKVLPQDKEYYKVKEPGESP JAK2 9111318
LTP
1.00
 SOCS1 SH2;
SOCS3 SH2		 TyrKc
0.27
 3E62 61.14%

Substrate: Epo-R (Receptor for erythropoietin, a major activator of erythropoiesis)
Seq-ID: P19235 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-73504   PTN6_HUMAN
MINT-74896   PTN6_MOUSE
MINT-6794748   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
erythropoietin receptor activity extracellular region,
integral to plasma membrane
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 426 PEGASAASFEYTILDPSSQLL - 10579919
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2		 -
0.45
 - low
Y 426 PEGASAASFEYTILDPSSQLL - 12027890
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2		 -
0.45
 - low
Y 426 PEGASAASFEYTILDPSSQLL - 12441334
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2		 -
0.45
 - low
Y 426 PEGASAASFEYTILDPSSQLL - 10660611
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2		 -
0.45
 - low
Y 454 ELPPTPPHLKYLYLVVSDSGI - 10579919
LTP
0.96
 CISH SH2;
PTPN6 SH2;
SOCS3 SH2;
STAT5 SH2;
SYK SH2		 -
0.37
 - low
Y 454 ELPPTPPHLKYLYLVVSDSGI - 12027890
LTP
0.96
 CISH SH2;
PTPN6 SH2;
SOCS3 SH2;
STAT5 SH2;
SYK SH2		 -
0.37
 - low
Y 456 PPTPPHLKYLYLVVSDSGIST - 10579919
LTP
1.00
 CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2		 -
0.36
 - low
Y 456 PPTPPHLKYLYLVVSDSGIST - 11443118
LTP
1.00
 CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2		 -
0.36
 - low
Y 456 PPTPPHLKYLYLVVSDSGIST - 12027890
LTP
1.00
 CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2		 -
0.36
 - low

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