List of substrates found:

PrlR  Tpo-R  STAT 5B  IL-9R alpha  Epo-R  GH-R  IL-6R (gp130)  IL-7R alpha  Insulin R  Common beta c subunit  PDGF-R beta  IL-2R beta  STAT 5 


Substrate: PrlR (Cytokin receptor)
Seq-ID: P16471 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 611 KCRLQLGGLDYLDPACFTHSF - 7537382
LTP
1.00
STAT5 SH2 -
0.22
- low

Substrate: Tpo-R (Thrombopoietin R mlp belongs to the hematopoietic R superfamily)
Seq-ID: P40238 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytokine receptor activity integral to plasma membrane cell proliferation
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 626 CCTTHIANHSYLPLSYWQQP  - 9122198
LTP
1.00
SHC1 SH2;
SHC PTB;
STAT5 SH2
-
0.18
- medium

Substrate: STAT 5B (Transcription factor)
Seq-ID: P51692 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 699 ESATAKAVDGYVKPQIKQVVP - 11751923
LTP
0.05
STAT5 SH2 SH2
0.32
- medium
Y 699 ESATAKAVDGYVKPQIKQVVP HCK 12411494
LTP
0.05
STAT5 SH2 SH2
0.32
- medium
Y 699 ESATAKAVDGYVKPQIKQVVP - 10830280
LTP
0.05
STAT5 SH2 SH2
0.32
- medium
Y 699 ESATAKAVDGYVKPQIKQVVP - 18083107
HTP
0.05
STAT5 SH2 SH2
0.32
- medium

Substrate: IL-9R alpha (Cytokin receptor)
Seq-ID: Q01113 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 407 CTEWRVQTLAYLPQEDWAPTS - 8756628
LTP
1.00
STAT5 SH2 -
0.37
- medium

Substrate: Epo-R (Receptor for erythropoietin, a major activator of erythropoiesis)
Seq-ID: P19235 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
erythropoietin receptor activity extracellular region,
integral to plasma membrane
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 368 PVGSEHAQDTYLVLDKWLLPR Lyn 10579919
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
STAT5 SH2;
SYK SH2
-
0.32
- low
Y 368 PVGSEHAQDTYLVLDKWLLPR JAK2 10579919
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
STAT5 SH2;
SYK SH2
-
0.32
- low
Y 426 PEGASAASFEYTILDPSSQLL - 10579919
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 426 PEGASAASFEYTILDPSSQLL - 12027890
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 426 PEGASAASFEYTILDPSSQLL - 12441334
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 426 PEGASAASFEYTILDPSSQLL - 10660611
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 454 ELPPTPPHLKYLYLVVSDSGI - 10579919
LTP
0.96
CISH SH2;
PTPN6 SH2;
SOCS3 SH2;
STAT5 SH2;
SYK SH2
-
0.37
- low
Y 454 ELPPTPPHLKYLYLVVSDSGI - 12027890
LTP
0.96
CISH SH2;
PTPN6 SH2;
SOCS3 SH2;
STAT5 SH2;
SYK SH2
-
0.37
- low
Y 456 PPTPPHLKYLYLVVSDSGIST - 10579919
LTP
1.00
CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2
-
0.36
- low
Y 456 PPTPPHLKYLYLVVSDSGIST - 11443118
LTP
1.00
CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2
-
0.36
- low
Y 456 PPTPPHLKYLYLVVSDSGIST - 12027890
LTP
1.00
CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2
-
0.36
- low
Y 504 IPAAEPLPPSYVACS       - 10579919
LTP
0.67
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2
-
0.34
- low
Y 504 IPAAEPLPPSYVACS       - 7559499
LTP
0.67
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2
-
0.34
- low
Y 504 IPAAEPLPPSYVACS       - 9573010
LTP
0.67
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2
-
0.34
- low

Substrate: GH-R (Growth hormon receptor)
Seq-ID: P10912 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 487 NPSSLSNIDFYAQVSDITPAG JAK2 9121492
LTP
1.00
CISH SH2;
GRB10 SH2;
SOCS2 SH2;
STAT3 SH2;
STAT5 SH2
-
0.42
- low
Y 534 CQENFLMDNAYFCEADAKKCI - 9121492
LTP
0.93
GRB10 SH2;
STAT3 SH2;
STAT5 SH2
-
0.16
- low
Y 534 CQENFLMDNAYFCEADAKKCI - 8647880
LTP
0.93
GRB10 SH2;
STAT3 SH2;
STAT5 SH2
-
0.16
- low
Y 566 IQPSLNQEDIYITTESLTTAA - 9121492
LTP
1.00
GRB10 SH2;
STAT3 SH2;
STAT5 SH2
-
0.47
- low
Y 566 IQPSLNQEDIYITTESLTTAA - 8647880
LTP
1.00
GRB10 SH2;
STAT3 SH2;
STAT5 SH2
-
0.47
- low
Y 627 PDKEFLSSCGYVSTDQLNKIM - 9121492
LTP
1.00
STAT3 SH2;
STAT5 SH2
-
0.29
- low
Y 627 PDKEFLSSCGYVSTDQLNKIM - 8647880
LTP
1.00
STAT3 SH2;
STAT5 SH2
-
0.29
- low

Substrate: IL-6R (gp130) (gp130 is shared by members of the IL-6 family)
Seq-ID: P40189 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 759 SSQNTSSTVQYSTVVHSGYRH - 8934572
LTP
1.00
PTPN11 SH2;
SOCS3 SH2;
STAT5 SH2
-
0.61
- medium
Y 759 SSQNTSSTVQYSTVVHSGYRH - 9505191
LTP
1.00
PTPN11 SH2;
SOCS3 SH2;
STAT5 SH2
-
0.61
- medium

Substrate: IL-7R alpha (Cytokin receptor)
Seq-ID: P16871 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 449 TSLGSNQEEAYVTMSSFYQNQ - 7719938
LTP
1.00
PIK3R1 SH2;
STAT5 SH2
-
0.40
- medium

Substrate: Insulin R (Receptor tyrosine kinase)
Seq-ID: P06213 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 999 GPLYASSNPEYLSASDVFPCS INSR 8662806
LTP
1.00
CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2
-
0.11
--
Y 999 GPLYASSNPEYLSASDVFPCS INSR 1658004
LTP
1.00
CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2
-
0.11
--
Y 999 GPLYASSNPEYLSASDVFPCS - 8393870
LTP
1.00
CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2
-
0.11
--
Y 999 GPLYASSNPEYLSASDVFPCS INSR 10340378
LTP
1.00
CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2
-
0.11
--

Substrate: Common beta c subunit (Cytokine recpetor common beta chain)
Seq-ID: P32927 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 628 QKSPPPGSLEYLCLPAGGQVQ - 9257712
LTP
1.00
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2;
STAT5 SH2
-
0.71
- medium
Y 628 QKSPPPGSLEYLCLPAGGQVQ - 10362354
LTP
1.00
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2;
STAT5 SH2
-
0.71
- medium
Y 766 PGPVKSGFEGYVELPPIEGRS - 9257712
LTP
1.00
PTPN11 SH2;
SHC1 SH2;
SHC_group SH2;
STAT5 SH2
-
0.69
- medium

Substrate: PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID: P09619 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 579 IESVSSDGHEYIYVDPMQLPY PDGFR_beta 8195171
LTP
1.00
Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2
-
0.15
- medium
Y 581 SVSSDGHEYIYVDPMQLPYDS PDGFR_beta 8617789
LTP
1.00
Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2
-
0.16
- medium
Y 775 DIESSNYMAPYDNYVPSAPER PDGFR_beta 8940081
LTP
1.00
GRB2 SH2;
GRB7 SH2;
STAT5 SH2
TyrKc
0.34
- medium

Substrate: IL-2R beta (Cytokin receptor)
Seq-ID: P14784 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 418 LQPLSGEDDAYCTFPSRDDLL Lck 10214954
LTP
1.00
SHB SH2;
STAT5 SH2
-
0.55
- medium
Y 536 NARLPLNTDAYLSLQELQGQD Lck 10214954
LTP
1.00
SHB SH2;
STAT5 SH2
-
0.71
- medium

Substrate: STAT 5 (Transcription factor)
Seq-ID: P42229 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 694 TPVLAKAVDGYVKPQIKQVVP Lyn 11641791
LTP
0.25
CRKL SH2;
PTPN11 SH2;
STAT5 SH2
SH2
0.20
- medium
Y 694 TPVLAKAVDGYVKPQIKQVVP SRC 11641791
LTP
0.25
CRKL SH2;
PTPN11 SH2;
STAT5 SH2
SH2
0.20
- medium
Y 694 TPVLAKAVDGYVKPQIKQVVP JAK2 11641791
LTP
0.25
CRKL SH2;
PTPN11 SH2;
STAT5 SH2
SH2
0.20
- medium
Y 694 TPVLAKAVDGYVKPQIKQVVP - 17081983
HTP
0.25
CRKL SH2;
PTPN11 SH2;
STAT5 SH2
SH2
0.20
- medium
Y 694 TPVLAKAVDGYVKPQIKQVVP - 18083107
HTP
0.25
CRKL SH2;
PTPN11 SH2;
STAT5 SH2
SH2
0.20
- medium


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