List of substrates found:


Substrate: C/EBP alpha (Transcription factor)
Seq-ID: P53566 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
MINT-5225582   FOXO1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein homodimerization activity,
specific RNA polymerase II transcription factor activity,
RNA polymerase II transcription factor activity, enhancer binding,
transcription factor binding,
promoter binding		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
lung development,
macrophage differentiation,
transcription,
cytokine-mediated signaling pathway,
negative regulation of cell proliferation,
white fat cell differentiation,
cellular response to organic cyclic substance,
urea cycle,
embryonic placenta development,
cell maturation,
brown fat cell differentiation,
liver development,
positive regulation of fat cell differentiation,
cellular response to lithium ion,
negative regulation of transcription from RNA polymerase II promoter,
mitochondrion organization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 193 PPPPPPHPHASPAHLAAPHLQ CDK4 16537903
LTP
0.56
 - -
0.92
 - low

Substrate: Retinoblastoma like 1 (Cell cycle control protein)
Seq-ID: P28749 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-66377   BEGIN_HUMAN
MINT-68425   RBBP8_HUMAN
MINT-73347   VE7_HPV16
MINT-4303197   DHX30_HUMAN
MINT-4303473   NR2E3_HUMAN
MINT-4303617   RBBP7_HUMAN
MINT-6665117   E1A_ADE05
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription factor binding chromatin modification,
transcription,
cell cycle,
regulation of lipid kinase activity,
interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 369 FEKKRSFAPSTPLTGRRYLRE CDK4 12006580
LTP
1.00
 - -
0.41
 - low
S 640 GSLRRDMQPLSPISVHERYSS CDK4 12006580
LTP
1.00
 - -
0.58
 - low
S 640 GSLRRDMQPLSPISVHERYSS CDK4 11884610
LTP
1.00
 - -
0.58
 - low
S 650 SPISVHERYSSPTAGSAKRRL CDK4 12006580
LTP
1.00
 - -
0.55
 - low
S 964 QDHMMDAPPLSPFPHIKQQPG CDK4 12006580
LTP
0.99
 - -
0.74
 - low
S 975 PFPHIKQQPGSPRRISQQHSI CDK4 12006580
LTP
1.00
 MOD_CDK_SPxK_1
 - -
0.66
 - low
S 975 PFPHIKQQPGSPRRISQQHSI CDK4 11884610
LTP
1.00
 MOD_CDK_SPxK_1
 - -
0.66
 - low
S 975 PFPHIKQQPGSPRRISQQHSI CDK4 10069453
LTP
1.00
 MOD_CDK_SPxK_1
 - -
0.66
 - low

Substrate: Retinoblastoma like 2 (Cell cycle control protein)
Seq-ID: Q08999 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16160   RBBP8_HUMAN
MINT-68815   VE7_HPV16
MINT-6665139   E1A_ADE05
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
protein binding		 chromatin modification,
transcription,
regulation of transcription,
cell cycle,
regulation of lipid kinase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 401 FDKSKALRISTPLTGVRYIKE CDK4 11157749
LTP
1.00
 - -
0.31
 - medium
S 672 SPTTLYDRYSSPPASTTRRRL CDK4 11157749
LTP
1.00
 - -
0.61
 - medium
S 1035 SQANMDAPPLSPYPFVRTGSP CDK4 11157749
LTP
1.00
 - -
0.68
 - medium

Substrate: SMAD3 (Transcription regulatory protein)
Seq-ID: P84022 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14023   CEBPB_HUMAN
MINT-15105   MED15_HUMAN
MINT-19375   LAP2_MOUSE
MINT-51235   SRBP2_HUMAN
MINT-51239   41_HUMAN
MINT-51243   MYO5B_HUMAN
MINT-51244   TPM3_HUMAN
MINT-51245   CRK_HUMAN
MINT-51247   GT2D1_HUMAN
MINT-51248   LMNA_HUMAN
MINT-51249   VIME_HUMAN
MINT-51250   SF3A1_HUMAN
MINT-51251   ACTB_HUMAN
MINT-51253   PYGL_HUMAN
MINT-61695   MLL4_HUMAN
MINT-61696   KU70_HUMAN
MINT-61697   KDM2A_HUMAN
MINT-61703   GMEB1_HUMAN
MINT-61705   PCDH1_HUMAN
MINT-61707   ZEB2_HUMAN
MINT-61710   RANB9_HUMAN
MINT-61711   MCM3A_HUMAN
MINT-61716   MTF2_HUMAN
MINT-61717   CFDP1_HUMAN
MINT-61720   SP130_HUMAN
MINT-61721   NCOA6_HUMAN
MINT-61723   K1267_HUMAN
MINT-61726   ZEP1_HUMAN
MINT-61732   GI24_HUMAN
MINT-61733   FLNA_HUMAN
MINT-61734   RLA0_HUMAN
MINT-61735   RU17_HUMAN
MINT-61737   TGM2_HUMAN
MINT-61949   SMAD4_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transforming growth factor beta receptor binding,
protein homodimerization activity,
R-SMAD binding,
protein kinase binding,
co-SMAD binding,
ubiquitin protein ligase binding,
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity,
beta-catenin binding,
transcription factor binding,
promoter binding,
sequence-specific DNA binding transcription factor activity		 nuclear inner membrane,
receptor complex,
cytosol		 protein stabilization,
negative regulation of cell growth,
SMAD protein complex assembly,
cell cycle arrest,
positive regulation of canonical Wnt receptor signaling pathway,
positive regulation of catenin protein nuclear translocation,
activation of caspase activity,
immune response,
regulation of transforming growth factor beta receptor signaling pathway,
transport,
positive regulation of transcription factor import into nucleus,
regulation of transforming growth factor-beta2 production,
transforming growth factor beta receptor signaling pathway,
negative regulation of mitotic cell cycle,
wound healing,
induction of apoptosis,
positive regulation of epithelial to mesenchymal transition,
cell-cell junction organization,
negative regulation of protein amino acid phosphorylation,
primary microRNA processing,
transcription,
evasion of host defenses by virus,
negative regulation of protein catabolic process,
response to hypoxia
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 8    MSSILPFTPPIVKRLLGW CDK4 15520018
LTP
1.00
 - -
0.17
 1OZJ 32.19%
T 179 GIEPQSNIPETPPPGYLSEDG CDK4 15241418
LTP
0.57
 MOD_ProDKin_1
 - -
0.80
 --
S 213 GSPNLSPNPMSPAHNNLDLQP CDK4 15241418
LTP
0.82
 MOD_ProDKin_1
 - -
0.68
 --

Substrate: UBF-1 (Transcription factor)
Seq-ID: P17480 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-62331   ZMYM2_HUMAN
MINT-63514   SCG1_HUMAN
MINT-1894291   FBRL_HUMAN
MINT-4543985   SET_HUMAN
MINT-7720853   CEBPA_HUMAN
MINT-7971422   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
RNA polymerase I transcription factor activity,
protein binding		 nucleolus,
nucleoplasm		 transcription,
positive regulation of transcription from RNA polymerase I promoter
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 484 EREERGKLPESPKRAEEIWQQ CDK4 10202152
LTP
0.08
 MOD_CDK_SPxK_1
 - HMG
0.70
 --

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