List of substrates found:


Substrate: Cdc25A (Protein tyrosine phosphatase activity)
Seq-ID: P79923 [Xenopus laevis]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 120 HTRIPIGRRNSLPQNLLGSSP CHK1 15272308
LTP
1.00
- M-inducer_phosp
0.54
- low
S 137 GSSPAFKRNLSYSLECEVFHL CHK1 15272308
LTP
0.28
- M-inducer_phosp
0.23
- low
S 190 GKEGLVQRQKSAPACMLSSPR CHK1 15272308
LTP
1.00
- M-inducer_phosp
0.58
- low
S 295 DTPEKSKRRKSMSEIVNEGLD CHK1 15272308
LTP
1.00
- M-inducer_phosp
0.65
- low
T 504 DLRKFRMKSRTWAGERSKREL CHK1 15272308
LTP
1.00
- -
0.30
- low

Substrate: cdc25A (Dual specificity phosphatase)
Seq-ID: P30304 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 76 KNNSNLQRMGSSESTDSGFCL CHK1 14681206
LTP
1.00
- -
0.62
- high
S 76 KNNSNLQRMGSSESTDSGFCL CHK1 12759351
LTP
1.00
- -
0.62
- high
S 124 GCSPALKRSHSDSLDHDIFQL CHK1 12399544
LTP
0.29
- M-inducer_phosp
0.45
- high
S 124 GCSPALKRSHSDSLDHDIFQL CHK1 12676583
LTP
0.29
- M-inducer_phosp
0.45
- high
S 124 GCSPALKRSHSDSLDHDIFQL CHK1 12759351
LTP
0.29
- M-inducer_phosp
0.45
- high
S 178 GKDLFTQRQNSAPARMLSSNE CHK1 12676583
LTP
1.00
- M-inducer_phosp
0.69
- high
S 279 TRSVLKRPERSQEESPPGSTK CHK1 12676583
LTP
0.07
- M-inducer_phosp
0.89
- high
S 293 SPPGSTKRRKSMSGASPKEST CHK1 12676583
LTP
1.00
- M-inducer_phosp
0.89
- high
T 507 DLKKFRTKSRTWAGEKSKREM CHK1 14559997
LTP
1.00
- -
0.37
- high

Substrate: cdc25B (Dual specificity phosphatase)
Seq-ID: P30305 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 230 RREAFAQRPSSAPDLMCLSPD CHK1 17003105
LTP
1.00
- M-inducer_phosp
0.53
- medium

Substrate: DNA replication licensing factor MCM4 (DNA binding protein)
Seq-ID: P33991 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 54 STGELQPMPTSPGVDLQSPAA CHK1 12714602
LTP
0.15
- -
0.93
- medium

Substrate: p53 (Cellular tumor antigen p53)
Seq-ID: P04637 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13742   CHK2_HUMAN
MINT-15878   UBP7_HUMAN
MINT-16161   BRCA1_HUMAN
MINT-16977   PARP1_HUMAN
MINT-19990   PIN1_HUMAN
MINT-24859   ASPP2_HUMAN
MINT-45889   CEBPZ_HUMAN
MINT-49767   ATM_HUMAN
MINT-50577   SAE1_HUMAN
MINT-56524   SP1_HUMAN
MINT-58470   MED1_HUMAN
MINT-58672   HNRL1_HUMAN
MINT-60094   HIPK2_HUMAN
MINT-61312   MK08_HUMAN
MINT-61317   WWOX_HUMAN
MINT-62206   PP1A_HUMAN
MINT-63290   ARI2_HUMAN
MINT-63365   KITH_HUMAN
MINT-63497   ZNF24_HUMAN
MINT-63537   IF2B_HUMAN
MINT-63547   RAB4A_HUMAN
MINT-63559   SAT1_HUMAN
MINT-64119   STX5_HUMAN
MINT-64188   MD2BP_HUMAN
MINT-64748   K0087_HUMAN
MINT-65132   HSPB1_HUMAN
MINT-65272   MPH6_HUMAN
MINT-68565   BMX_HUMAN
MINT-74886   NPM_HUMAN
MINT-74925   1433Z_HUMAN
MINT-1795431   NMT1_HUMAN
MINT-1891378   CDN1A_HUMAN
MINT-1958329   CHK1_HUMAN
MINT-2634790   RGRF1_HUMAN
MINT-2858243   DVL2_HUMAN
MINT-2866927   SCAM1_HUMAN
MINT-3390028   KC1D_RAT
MINT-3979604   P53_MOUSE
MINT-4049689   NR4A1_HUMAN
MINT-4052116   SYVN1_HUMAN
MINT-4052873   GRP78_HUMAN
MINT-4302642   HS71L_HUMAN
MINT-4303978   XPO1_HUMAN
MINT-4329805   TOPRS_HUMAN
MINT-4793180   EGR1_HUMAN
MINT-4793253   GSK3B_HUMAN
MINT-4793489   PML_HUMAN
MINT-5114724   ZN363_HUMAN
MINT-5207405   HDAC8_HUMAN
MINT-6540866   PSME3_HUMAN
MINT-6540889   MDM2_HUMAN
MINT-6628692   LT_SV40
MINT-6665320   CBP_HUMAN
MINT-6701342   MAP1B_HUMAN
MINT-7013631   PA1_HUMAN
MINT-7013916   RYBP_HUMAN
MINT-7103733   ANDR_HUMAN
MINT-7144912   TOE1_HUMAN
MINT-7222784   FRAP_HUMAN
MINT-7263630   EP300_HUMAN
MINT-7266250   PLK1_HUMAN
MINT-7294020   FAK1_HUMAN
MINT-7295816   IKKB_HUMAN
MINT-7557644   GRP75_HUMAN
MINT-7711943   1433S_HUMAN
MINT-7717378   PHB_HUMAN
MINT-7718917   SNAI1_HUMAN
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 20 VEPPLSQETFSDLWKLLPENN CHK1 17339337
LTP
0.95
- P53_TAD
0.60
--

Substrate: p73 (Member of the TP53 family. It participates in the apoptotic response to DNA damage)
Seq-ID: O15350 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 47 GNNEVVGGTDSSMDVFHLEGM CHK1 14585975
LTP
0.52
- -
0.61
- medium

Substrate: TLK1 (Serine/threonine-protein kinase)
Seq-ID: Q9UKI8 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 743 YLLPHMRRSNSSGNLHMAGLT CHK1 12660173
LTP
0.65
- -
0.44
- medium

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