List of substrates found:


Substrate: Cdc25A (Protein tyrosine phosphatase activity)
Seq-ID: P79923 [Xenopus laevis]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein tyrosine phosphatase activity intracellular protein amino acid dephosphorylation,
M phase of mitotic cell cycle
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 120 HTRIPIGRRNSLPQNLLGSSP CHK1 15272308
LTP
1.00
 - M-inducer_phosp
0.54
 - low
S 137 GSSPAFKRNLSYSLECEVFHL CHK1 15272308
LTP
0.28
 - M-inducer_phosp
0.23
 - low
S 190 GKEGLVQRQKSAPACMLSSPR CHK1 15272308
LTP
1.00
 - M-inducer_phosp
0.58
 - low
S 295 DTPEKSKRRKSMSEIVNEGLD CHK1 15272308
LTP
1.00
 - M-inducer_phosp
0.65
 - low
T 504 DLRKFRMKSRTWAGERSKREL CHK1 15272308
LTP
1.00
 - -
0.30
 - low

Substrate: cdc25A (Dual specificity phosphatase)
Seq-ID: P30304 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-15591   CHK2_HUMAN
MINT-3294407   1433Z_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein tyrosine phosphatase activity,
protein binding		 nucleoplasm regulation of cyclin-dependent protein kinase activity,
cell division,
protein amino acid dephosphorylation,
mitosis,
DNA replication,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 76 KNNSNLQRMGSSESTDSGFCL CHK1 14681206
LTP
1.00
 - -
0.62
 - high
S 76 KNNSNLQRMGSSESTDSGFCL CHK1 12759351
LTP
1.00
 - -
0.62
 - high
S 124 GCSPALKRSHSDSLDHDIFQL CHK1 12399544
LTP
0.29
 - M-inducer_phosp
0.45
 - high
S 124 GCSPALKRSHSDSLDHDIFQL CHK1 12676583
LTP
0.29
 - M-inducer_phosp
0.45
 - high
S 124 GCSPALKRSHSDSLDHDIFQL CHK1 12759351
LTP
0.29
 - M-inducer_phosp
0.45
 - high
S 178 GKDLFTQRQNSAPARMLSSNE CHK1 12676583
LTP
1.00
 - M-inducer_phosp
0.69
 - high
S 279 TRSVLKRPERSQEESPPGSTK CHK1 12676583
LTP
0.07
 - M-inducer_phosp
0.89
 - high
S 293 SPPGSTKRRKSMSGASPKEST CHK1 12676583
LTP
1.00
 - M-inducer_phosp
0.89
 - high
T 507 DLKKFRTKSRTWAGEKSKREM CHK1 14559997
LTP
1.00
 - -
0.37
 - high

Substrate: cdc25B (Dual specificity phosphatase)
Seq-ID: P30305 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19329   1433Z_HUMAN
MINT-19330   1433F_HUMAN
MINT-25122   1433B_HUMAN
MINT-51069   1433S_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein tyrosine phosphatase activity,
protein binding		 cytosol,
microtubule organizing center,
nucleoplasm		 positive regulation of cell proliferation,
cell division,
protein amino acid dephosphorylation,
mitosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 230 RREAFAQRPSSAPDLMCLSPD CHK1 17003105
LTP
1.00
 - M-inducer_phosp
0.53
 - medium

Substrate: DNA replication licensing factor MCM4 (DNA binding protein)
Seq-ID: P33991 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-2984401   SSRP1_HUMAN
MINT-2984454   SP16H_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ATP binding,
protein binding		 nucleoplasm transcription,
regulation of transcription,
DNA-dependent DNA replication initiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 54 STGELQPMPTSPGVDLQSPAA CHK1 12714602
LTP
0.15
 - -
0.93
 - medium

Substrate: p53 (Cellular tumor antigen p53)
Seq-ID: P04637 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13742   CHK2_HUMAN
MINT-15878   UBP7_HUMAN
MINT-16161   BRCA1_HUMAN
MINT-16977   PARP1_HUMAN
MINT-19990   PIN1_HUMAN
MINT-24859   ASPP2_HUMAN
MINT-45889   CEBPZ_HUMAN
MINT-49767   ATM_HUMAN
MINT-50577   SAE1_HUMAN
MINT-56524   SP1_HUMAN
MINT-58470   MED1_HUMAN
MINT-58672   HNRL1_HUMAN
MINT-60094   HIPK2_HUMAN
MINT-61312   MK08_HUMAN
MINT-61317   WWOX_HUMAN
MINT-62206   PP1A_HUMAN
MINT-63290   ARI2_HUMAN
MINT-63365   KITH_HUMAN
MINT-63497   ZNF24_HUMAN
MINT-63537   IF2B_HUMAN
MINT-63547   RAB4A_HUMAN
MINT-63559   SAT1_HUMAN
MINT-64119   STX5_HUMAN
MINT-64188   MD2BP_HUMAN
MINT-64748   K0087_HUMAN
MINT-65132   HSPB1_HUMAN
MINT-65272   MPH6_HUMAN
MINT-68565   BMX_HUMAN
MINT-74886   NPM_HUMAN
MINT-74925   1433Z_HUMAN
MINT-1795431   NMT1_HUMAN
MINT-1891378   CDN1A_HUMAN
MINT-1958329   CHK1_HUMAN
MINT-2634790   RGRF1_HUMAN
MINT-2858243   DVL2_HUMAN
MINT-2866927   SCAM1_HUMAN
MINT-3390028   KC1D_RAT
MINT-3979604   P53_MOUSE
MINT-4049689   NR4A1_HUMAN
MINT-4052116   SYVN1_HUMAN
MINT-4052873   GRP78_HUMAN
MINT-4302642   HS71L_HUMAN
MINT-4303978   XPO1_HUMAN
MINT-4329805   TOPRS_HUMAN
MINT-4793180   EGR1_HUMAN
MINT-4793253   GSK3B_HUMAN
MINT-4793489   PML_HUMAN
MINT-5114724   ZN363_HUMAN
MINT-5207405   HDAC8_HUMAN
MINT-6540866   PSME3_HUMAN
MINT-6540889   MDM2_HUMAN
MINT-6628692   LT_SV40
MINT-6665320   CBP_HUMAN
MINT-6701342   MAP1B_HUMAN
MINT-7013631   PA1_HUMAN
MINT-7013916   RYBP_HUMAN
MINT-7103733   ANDR_HUMAN
MINT-7144912   TOE1_HUMAN
MINT-7222784   FRAP_HUMAN
MINT-7263630   EP300_HUMAN
MINT-7266250   PLK1_HUMAN
MINT-7294020   FAK1_HUMAN
MINT-7295816   IKKB_HUMAN
MINT-7557644   GRP75_HUMAN
MINT-7711943   1433S_HUMAN
MINT-7717378   PHB_HUMAN
MINT-7718917   SNAI1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription activator activity,
protease binding,
DNA strand annealing activity,
chromatin binding,
copper ion binding,
ATP binding,
transcription factor binding,
chaperone binding,
zinc ion binding,
histone acetyltransferase binding,
promoter binding,
sequence-specific DNA binding transcription factor activity,
protein N-terminus binding,
protein heterodimerization activity,
protein phosphatase 2A binding,
protein kinase binding,
ubiquitin protein ligase binding		 nucleolus,
nuclear matrix,
insoluble fraction,
protein complex,
endoplasmic reticulum,
PML body,
mitochondrion		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
senescence,
mitotic cell cycle G1/S DNA damage checkpoint,
cell cycle arrest,
regulation of mitochondrial membrane permeability,
response to gamma radiation,
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,
response to tumor cell,
ER overload response,
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis,
interspecies interaction between organisms,
Ras protein signal transduction,
nucleotide-excision repair,
protein tetramerization,
cellular response to glucose starvation,
negative regulation of helicase activity,
negative regulation of cell growth,
base-excision repair,
activation of caspase activity by cytochrome c,
cell aging
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 20 VEPPLSQETFSDLWKLLPENN CHK1 17339337
LTP
0.95
 - P53_TAD
0.60
 --

Substrate: p73 (Member of the TP53 family. It participates in the apoptotic response to DNA damage)
Seq-ID: O15350 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-13681   EP300_HUMAN
MINT-45880   ASPP1_HUMAN
MINT-45891   CEBPZ_HUMAN
MINT-60132   WWOX_HUMAN
MINT-3389173   ITCH_HUMAN
MINT-7309761   ABL1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription activator activity,
transcription factor binding,
zinc ion binding,
promoter binding,
sequence-specific DNA binding transcription factor activity,
protein binding		 nucleus mismatch repair,
transcription,
negative regulation of cell growth,
positive regulation of gene-specific transcription,
response to tumor cell,
DNA damage response, signal transduction resulting in induction of apoptosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 47 GNNEVVGGTDSSMDVFHLEGM CHK1 14585975
LTP
0.52
 - -
0.61
 - medium

Substrate: TLK1 (Serine/threonine-protein kinase)
Seq-ID: Q9UKI8 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-17055   SNP23_HUMAN
MINT-67546   ASF1A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding,
protein binding		 nucleus intracellular signaling pathway,
protein amino acid phosphorylation,
chromatin modification,
cell cycle,
regulation of chromatin assembly or disassembly,
intracellular protein transport,
response to DNA damage stimulus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 743 YLLPHMRRSNSSGNLHMAGLT CHK1 12660173
LTP
0.65
 - -
0.44
 - medium

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