List of substrates found:


Substrate: Beclin-1 (Protein binding)
Seq-ID: Q14457 [Homo sapiens]
Download:fasta csv
Interaction Network(s):
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-4821036   MCL1_HUMAN
MINT-7014569   DAPK1_HUMAN
MINT-7014585   B2CL1_HUMAN
MINT-7712827   BCL2_HUMAN
MINT-7969366   BIRC5_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding membrane anti-apoptosis,
cellular defense response,
response to virus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 119 MENLSRRLKVTGDLFDIMSGQ DAPK1 19180116
LTP
0.23
 - APG6
0.42
 - medium

Substrate: Calcium/calmodulin-dependent protein kinase kinase 2 (Ser/Thr protein kinase family)
Seq-ID: Q96RR4 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium ion binding,
ATP binding,
protein tyrosine kinase activity,
calmodulin-dependent protein kinase activity,
calmodulin binding		 cytoplasm positive regulation of transcription,
calcium-mediated signaling,
MAPKKK cascade,
protein amino acid autophosphorylation,
regulation of protein kinase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 511 EGSRREERSLSAPGNLLTKKP DAPK1 15209507
LTP
0.96
 - -
0.74
 - high

Substrate: DAP kinase 1 (Serine/threonine kinase)
Seq-ID: P53355 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
MINT-7014569   BECN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding,
calmodulin binding		 cytoplasm,
actin cytoskeleton		 induction of apoptosis by extracellular signals,
protein amino acid phosphorylation,
apoptosis,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 308 KFAARKKWKQSVRLISLCQRL DAPK1 11579085
LTP
1.00
 - -
0.14
 - medium

Substrate: DAP kinase 1 (Serine/threonine kinase)
Seq-ID: Q80YE7 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding,
calmodulin binding		 cytoplasm induction of apoptosis by extracellular signals,
protein amino acid phosphorylation,
apoptosis,
anti-apoptosis,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 308 KFAARKKWKQSVRLISLCQRL DAPK1 15729359
LTP
1.00
 - -
0.14
 - medium

Substrate: DNA replication licensing factor MCM3 (DNA binding protein)
Seq-ID: P25205 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-50402   CDC6_HUMAN
MINT-50413   CDK2_HUMAN
MINT-2984350   SSRP1_HUMAN
MINT-3307756   1433Z_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
nucleoside-triphosphatase activity,
ATP binding,
protein binding		 centrosome,
alpha DNA polymerase:primase complex,
nucleoplasm		 transcription,
regulation of transcription,
cell cycle,
DNA-dependent DNA replication initiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 160 ATKKTIERRYSDLTTLVAFPS DAPK1 18283219
LTP
0.10
 - MCM
0.25
 - medium

Substrate: Mylc2 (Unclassified)
Seq-ID: Q3THE2 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-1953648   UBIQ_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium ion binding,
motor activity		 myosin complex,
apical part of cell
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 19 KTTKKRPQRATSNVFAMFDQS DAPK1 14600263
LTP
0.90
 - -
0.54
 - medium

Substrate: p53 (Cellular tumor antigen p53)
Seq-ID: P04637 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13742   CHK2_HUMAN
MINT-15878   UBP7_HUMAN
MINT-16161   BRCA1_HUMAN
MINT-16977   PARP1_HUMAN
MINT-19990   PIN1_HUMAN
MINT-24859   ASPP2_HUMAN
MINT-45889   CEBPZ_HUMAN
MINT-49767   ATM_HUMAN
MINT-50577   SAE1_HUMAN
MINT-56524   SP1_HUMAN
MINT-58470   MED1_HUMAN
MINT-58672   HNRL1_HUMAN
MINT-60094   HIPK2_HUMAN
MINT-61312   MK08_HUMAN
MINT-61317   WWOX_HUMAN
MINT-62206   PP1A_HUMAN
MINT-63290   ARI2_HUMAN
MINT-63365   KITH_HUMAN
MINT-63497   ZNF24_HUMAN
MINT-63537   IF2B_HUMAN
MINT-63547   RAB4A_HUMAN
MINT-63559   SAT1_HUMAN
MINT-64119   STX5_HUMAN
MINT-64188   MD2BP_HUMAN
MINT-64748   K0087_HUMAN
MINT-65132   HSPB1_HUMAN
MINT-65272   MPH6_HUMAN
MINT-68565   BMX_HUMAN
MINT-74886   NPM_HUMAN
MINT-74925   1433Z_HUMAN
MINT-1795431   NMT1_HUMAN
MINT-1891378   CDN1A_HUMAN
MINT-1958329   CHK1_HUMAN
MINT-2634790   RGRF1_HUMAN
MINT-2858243   DVL2_HUMAN
MINT-2866927   SCAM1_HUMAN
MINT-3390028   KC1D_RAT
MINT-3979604   P53_MOUSE
MINT-4049689   NR4A1_HUMAN
MINT-4052116   SYVN1_HUMAN
MINT-4052873   GRP78_HUMAN
MINT-4302642   HS71L_HUMAN
MINT-4303978   XPO1_HUMAN
MINT-4329805   TOPRS_HUMAN
MINT-4793180   EGR1_HUMAN
MINT-4793253   GSK3B_HUMAN
MINT-4793489   PML_HUMAN
MINT-5114724   ZN363_HUMAN
MINT-5207405   HDAC8_HUMAN
MINT-6540866   PSME3_HUMAN
MINT-6540889   MDM2_HUMAN
MINT-6628692   LT_SV40
MINT-6665320   CBP_HUMAN
MINT-6701342   MAP1B_HUMAN
MINT-7013631   PA1_HUMAN
MINT-7013916   RYBP_HUMAN
MINT-7103733   ANDR_HUMAN
MINT-7144912   TOE1_HUMAN
MINT-7222784   FRAP_HUMAN
MINT-7263630   EP300_HUMAN
MINT-7266250   PLK1_HUMAN
MINT-7294020   FAK1_HUMAN
MINT-7295816   IKKB_HUMAN
MINT-7557644   GRP75_HUMAN
MINT-7711943   1433S_HUMAN
MINT-7717378   PHB_HUMAN
MINT-7718917   SNAI1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription activator activity,
protease binding,
DNA strand annealing activity,
chromatin binding,
copper ion binding,
ATP binding,
transcription factor binding,
chaperone binding,
zinc ion binding,
histone acetyltransferase binding,
promoter binding,
sequence-specific DNA binding transcription factor activity,
protein N-terminus binding,
protein heterodimerization activity,
protein phosphatase 2A binding,
protein kinase binding,
ubiquitin protein ligase binding		 nucleolus,
nuclear matrix,
insoluble fraction,
protein complex,
endoplasmic reticulum,
PML body,
mitochondrion		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
senescence,
mitotic cell cycle G1/S DNA damage checkpoint,
cell cycle arrest,
regulation of mitochondrial membrane permeability,
response to gamma radiation,
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,
response to tumor cell,
ER overload response,
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis,
interspecies interaction between organisms,
Ras protein signal transduction,
nucleotide-excision repair,
protein tetramerization,
cellular response to glucose starvation,
negative regulation of helicase activity,
negative regulation of cell growth,
base-excision repair,
activation of caspase activity by cytochrome c,
cell aging
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 20 VEPPLSQETFSDLWKLLPENN DAPK1 17339337
LTP
0.95
 - P53_TAD
0.60
 --

Substrate: Syntaxin 1A (Membrane transport protein)
Seq-ID: P32851 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
MINT-24792   STXB1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ATP-dependent protein binding,
calcium-dependent protein binding,
protein heterodimerization activity,
protein domain specific binding,
SNAP receptor activity,
glycoprotein binding,
myosin head/neck binding,
protein binding, bridging,
SNARE binding,
protein N-terminus binding		 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex,
cell junction,
actomyosin,
integral to membrane,
synaptic vesicle membrane,
synaptosome,
synaptobrevin 2-SNAP-25-syntaxin-1a complex,
stored secretory granule		 synaptic vesicle docking involved in exocytosis,
intracellular protein transport,
positive regulation of exocytosis,
response to gravity,
positive regulation of neurotransmitter secretion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 188 ASGIIMDSSISKQALSEIETR DAPK1 12730201
LTP
0.36
 - t_SNARE
0.31
 1SFC 125.41%

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