List of substrates found:


Substrate: c-Jun (c-Jun (Transcription factor AP-1))
Seq-ID: P05412 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14077   DDX21_HUMAN
MINT-68803   VE7_HPV16
MINT-68804   FOS_HUMAN
MINT-6628041   ATF2_HUMAN
MINT-6628056   CITE1_HUMAN
MINT-7148314   MK08_HUMAN
MINT-7148323   MK09_HUMAN
MINT-7148332   MK10_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription repressor activity,
R-SMAD binding,
RNA polymerase II transcription factor activity, enhancer binding,
Rho GTPase activator activity,
transcription coactivator activity,
promoter binding		 SMAD protein nuclear translocation,
positive regulation by host of viral transcription,
SMAD protein signal transduction,
negative regulation of DNA binding,
transforming growth factor beta receptor signaling pathway,
positive regulation of transcription from RNA polymerase II promoter
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 249 TPPLSPIDMESQERIKAERKR DNA-PK 8464713
LTP
0.13
 MOD_PIKK_1
 - COIL
0.82
 --

Substrate: DNA ligase IV (DNA ligase IV)
Seq-ID: P49917 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
protein C-terminus binding,
metal ion binding,
ATP binding,
DNA ligase (ATP) activity		 condensed chromosome,
DNA-dependent protein kinase-DNA ligase 4 complex,
DNA ligase IV complex		 chromosome organization,
central nervous system development,
cell division,
positive regulation of neurogenesis,
isotype switching,
DNA ligation involved in DNA recombination,
cell cycle,
T cell receptor V(D)J recombination,
in utero embryonic development,
response to gamma radiation,
response to X-ray,
nucleotide-excision repair, DNA gap filling,
neuron apoptosis,
initiation of viral infection,
negative regulation of neuron apoptosis,
somatic stem cell maintenance,
DNA replication,
T cell differentiation in the thymus,
single strand break repair,
DNA ligation involved in DNA repair,
cell proliferation,
double-strand break repair via nonhomologous end joining,
positive regulation of fibroblast proliferation,
pro-B cell differentiation,
provirus integration
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 650 IIEHLKAPNLTNVNKISNIFE DNA-PK 15194694
LTP
0.00
 - -
0.23
 --

Substrate: DNA-PKcs (Serine/threonine kinase)
Seq-ID: P78527 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-48229   NEMO_HUMAN
MINT-48504   M3K3_HUMAN
MINT-48684   NFKB1_HUMAN
MINT-48762   NFKB2_HUMAN
MINT-49029   RELB_HUMAN
MINT-49452   TNR1B_HUMAN
MINT-50940   1433B_HUMAN
MINT-72644   HS90B_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
ATP binding,
transcription factor binding,
DNA-dependent protein kinase activity		 transcription factor complex,
DNA-dependent protein kinase-DNA ligase 4 complex		 double-strand break repair via nonhomologous end joining,
positive regulation of gene-specific transcription from RNA polymerase II promoter,
peptidyl-serine phosphorylation,
cellular response to insulin stimulus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 2056 STGVQSYSYSSQDPRPATGRF DNA-PK 15677476
LTP
1.00
 MOD_PIKK_1
 - NUC194
0.51
 - medium
T 2609 STVLTPMFVETQASQGTLQTR DNA-PK 12186630
LTP
1.00
 MOD_PIKK_1
 - -
0.47
 - medium
T 2609 STVLTPMFVETQASQGTLQTR DNA-PK 15677476
LTP
1.00
 MOD_PIKK_1
 - -
0.47
 - medium
T 2609 STVLTPMFVETQASQGTLQTR DNA-PK 15258142
LTP
1.00
 MOD_PIKK_1
 - -
0.47
 - medium
S 2612 LTPMFVETQASQGTLQTRTQE DNA-PK 12186630
LTP
1.00
 MOD_PIKK_1
 - -
0.56
 - medium
S 2612 LTPMFVETQASQGTLQTRTQE DNA-PK 15258142
LTP
1.00
 MOD_PIKK_1
 - -
0.56
 - medium
T 2620 QASQGTLQTRTQEGSLSARWP DNA-PK 12186630
LTP
0.62
 MOD_PIKK_1
 - -
0.60
 - medium
T 2620 QASQGTLQTRTQEGSLSARWP DNA-PK 15258142
LTP
0.62
 MOD_PIKK_1
 - -
0.60
 - medium
T 2638 RWPVAGQIRATQQQHDFTLTQ DNA-PK 12186630
LTP
1.00
 MOD_PIKK_1
 - -
0.47
 - medium
T 2638 RWPVAGQIRATQQQHDFTLTQ DNA-PK 15258142
LTP
1.00
 MOD_PIKK_1
 - -
0.47
 - medium
T 2647 ATQQQHDFTLTQTADGRSSFD DNA-PK 12186630
LTP
1.00
 MOD_PIKK_1
 - -
0.50
 - medium
T 2647 ATQQQHDFTLTQTADGRSSFD DNA-PK 15258142
LTP
1.00
 MOD_PIKK_1
 - -
0.50
 - medium

Substrate: Glucocorticoid receptor (Transcription factor)
Seq-ID: P04150 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14116   1433S_HUMAN
MINT-3373920   LCK_HUMAN
MINT-3373954   CD4_HUMAN
MINT-3374054   CD3D_HUMAN
MINT-6771456   KS6A5_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sequence-specific DNA binding,
glucocorticoid receptor activity,
steroid binding,
zinc ion binding,
sequence-specific DNA binding transcription factor activity,
protein binding		 mitochondrial matrix,
nucleus		 transcription from RNA polymerase II promoter,
chromatin modification,
response to protein stimulus,
superior temporal gyrus development,
regulation of transcription, DNA-dependent
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 508 KGIQQATTGVSQETSENPGNK DNA-PK 9038175
LTP
0.24
 MOD_PIKK_1
 - -
0.62
 - low

Substrate: HSP 90-alpha (heat shock protein HSP 90-alpha (HSP 86) (from PhosphoBase))
Seq-ID: P07900 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13696   SYEP_HUMAN
MINT-17372   SYMC_HUMAN
MINT-17385   SYQ_HUMAN
MINT-48053   IKKA_HUMAN
MINT-48091   IKKB_HUMAN
MINT-48120   IKKE_HUMAN
MINT-48190   NEMO_HUMAN
MINT-48342   M3K1_HUMAN
MINT-48497   M3K3_HUMAN
MINT-48682   NFKB1_HUMAN
MINT-48760   NFKB2_HUMAN
MINT-48857   M3K14_HUMAN
MINT-49053   RIPK1_HUMAN
MINT-49073   RIPK2_HUMAN
MINT-49177   TAB1_HUMAN
MINT-49213   TAB2_HUMAN
MINT-49282   TBK1_HUMAN
MINT-63931   RS3A_HUMAN
MINT-3305183   1433Z_HUMAN
MINT-3373863   LCK_HUMAN
MINT-3374106   ZAP70_HUMAN
MINT-3378991   FKBP8_HUMAN
MINT-6550966   HIF1A_HUMAN
MINT-7710224   FKBP4_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein homodimerization activity,
TPR domain binding,
unfolded protein binding,
nitric-oxide synthase regulator activity,
ATP binding		 cytosol,
melanosome		 mitochondrial outer membrane translocase complex assembly,
response to unfolded protein,
positive regulation of nitric oxide biosynthetic process,
mitochondrial transport,
signal transduction,
protein refolding,
cellular chaperone-mediated protein complex assembly
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 7     MPEETQTQDQPMEEEEV DNA-PK 2507541
LTP
0.25
 MOD_PIKK_1
 - -
0.95
 --
T 7     MPEETQTQDQPMEEEEV DNA-PK 2507541
LTP
0.25
 MOD_PIKK_1
 - -
0.95
 --

Substrate: Large T antigen (Initiates DNA unwinding and replication)
Seq-ID: P03070 [Simian virus 40]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):
[show]
MINT-25007   RB_HUMAN
MINT-66006   FBXW7_HUMAN
MINT-69586   TF2B_HUMAN
MINT-69591   SP1_HUMAN
MINT-69732   RFA2_HUMAN
MINT-72894   CBP_MOUSE
MINT-72952   TOP1_HUMAN
MINT-72966   DPOLA_HUMAN
MINT-73224   P53_MOUSE
MINT-73228   RB_MOUSE
MINT-73241   RAN_HUMAN
MINT-77985   CDC2_HUMAN
MINT-6627946   PURA_HUMAN
MINT-6628476   CBP_HUMAN
MINT-6628502   EP300_HUMAN
MINT-6628595   HSP7C_MOUSE
MINT-6628637   IRS1_HUMAN
MINT-6628644   CSK21_HUMAN
MINT-6628661   H10_HUMAN
MINT-6628666   CDK2_HUMAN
MINT-6628680   BUB1_HUMAN
MINT-6628685   BUB3_HUMAN
MINT-6628692   P53_HUMAN
MINT-6628780   HDAC1_HUMAN
MINT-6628855   RFA1_HUMAN
MINT-6733240   IMA4_HUMAN
MINT-6733247   IMA2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
metal ion binding,
DNA replication origin binding,
ATP binding,
heat shock protein binding,
helicase activity		 host cell nucleus transcription,
regulation of transcription,
evasion by virus of host immune response,
DNA replication
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 665 EDSGHETGIDSQSQGSFQAPQ DNA-PK 1654434
LTP
0.14
 MOD_PIKK_1
 - Polyoma_lg_T_C
0.81
 - medium
S 667 SGHETGIDSQSQGSFQAPQSS DNA-PK 1654434
LTP
0.05
 MOD_PIKK_1
 - Polyoma_lg_T_C
0.81
 - medium
S 677 SQGSFQAPQSSQSVHDHNQPY DNA-PK 1654434
LTP
0.17
 MOD_PIKK_1
 - Polyoma_lg_T_C
0.76
 - medium

Substrate: p53 (Cellular tumor antigen p53)
Seq-ID: P04637 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13742   CHK2_HUMAN
MINT-15878   UBP7_HUMAN
MINT-16161   BRCA1_HUMAN
MINT-16977   PARP1_HUMAN
MINT-19990   PIN1_HUMAN
MINT-24859   ASPP2_HUMAN
MINT-45889   CEBPZ_HUMAN
MINT-49767   ATM_HUMAN
MINT-50577   SAE1_HUMAN
MINT-56524   SP1_HUMAN
MINT-58470   MED1_HUMAN
MINT-58672   HNRL1_HUMAN
MINT-60094   HIPK2_HUMAN
MINT-61312   MK08_HUMAN
MINT-61317   WWOX_HUMAN
MINT-62206   PP1A_HUMAN
MINT-63290   ARI2_HUMAN
MINT-63365   KITH_HUMAN
MINT-63497   ZNF24_HUMAN
MINT-63537   IF2B_HUMAN
MINT-63547   RAB4A_HUMAN
MINT-63559   SAT1_HUMAN
MINT-64119   STX5_HUMAN
MINT-64188   MD2BP_HUMAN
MINT-64748   K0087_HUMAN
MINT-65132   HSPB1_HUMAN
MINT-65272   MPH6_HUMAN
MINT-68565   BMX_HUMAN
MINT-74886   NPM_HUMAN
MINT-74925   1433Z_HUMAN
MINT-1795431   NMT1_HUMAN
MINT-1891378   CDN1A_HUMAN
MINT-1958329   CHK1_HUMAN
MINT-2634790   RGRF1_HUMAN
MINT-2858243   DVL2_HUMAN
MINT-2866927   SCAM1_HUMAN
MINT-3390028   KC1D_RAT
MINT-3979604   P53_MOUSE
MINT-4049689   NR4A1_HUMAN
MINT-4052116   SYVN1_HUMAN
MINT-4052873   GRP78_HUMAN
MINT-4302642   HS71L_HUMAN
MINT-4303978   XPO1_HUMAN
MINT-4329805   TOPRS_HUMAN
MINT-4793180   EGR1_HUMAN
MINT-4793253   GSK3B_HUMAN
MINT-4793489   PML_HUMAN
MINT-5114724   ZN363_HUMAN
MINT-5207405   HDAC8_HUMAN
MINT-6540866   PSME3_HUMAN
MINT-6540889   MDM2_HUMAN
MINT-6628692   LT_SV40
MINT-6665320   CBP_HUMAN
MINT-6701342   MAP1B_HUMAN
MINT-7013631   PA1_HUMAN
MINT-7013916   RYBP_HUMAN
MINT-7103733   ANDR_HUMAN
MINT-7144912   TOE1_HUMAN
MINT-7222784   FRAP_HUMAN
MINT-7263630   EP300_HUMAN
MINT-7266250   PLK1_HUMAN
MINT-7294020   FAK1_HUMAN
MINT-7295816   IKKB_HUMAN
MINT-7557644   GRP75_HUMAN
MINT-7711943   1433S_HUMAN
MINT-7717378   PHB_HUMAN
MINT-7718917   SNAI1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription activator activity,
protease binding,
DNA strand annealing activity,
chromatin binding,
copper ion binding,
ATP binding,
transcription factor binding,
chaperone binding,
zinc ion binding,
histone acetyltransferase binding,
promoter binding,
sequence-specific DNA binding transcription factor activity,
protein N-terminus binding,
protein heterodimerization activity,
protein phosphatase 2A binding,
protein kinase binding,
ubiquitin protein ligase binding		 nucleolus,
nuclear matrix,
insoluble fraction,
protein complex,
endoplasmic reticulum,
PML body,
mitochondrion		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
senescence,
mitotic cell cycle G1/S DNA damage checkpoint,
cell cycle arrest,
regulation of mitochondrial membrane permeability,
response to gamma radiation,
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,
response to tumor cell,
ER overload response,
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis,
interspecies interaction between organisms,
Ras protein signal transduction,
nucleotide-excision repair,
protein tetramerization,
cellular response to glucose starvation,
negative regulation of helicase activity,
negative regulation of cell growth,
base-excision repair,
activation of caspase activity by cytochrome c,
cell aging
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 15 QSDPSVEPPLSQETFSDLWKL DNA-PK 10446957
LTP
1.00
 MOD_PIKK_1
 - P53_TAD
0.73
 --
S 37 PENNVLSPLPSQAMDDLMLSP DNA-PK 11483158
LTP
0.47
 MOD_PIKK_1
 - -
0.65
 --
S 37 PENNVLSPLPSQAMDDLMLSP DNA-PK 15381073
LTP
0.47
 MOD_PIKK_1
 - -
0.65
 --
S 37 PENNVLSPLPSQAMDDLMLSP DNA-PK 12959929
LTP
0.47
 MOD_PIKK_1
 - -
0.65
 --
S 37 PENNVLSPLPSQAMDDLMLSP DNA-PK
LTP
0.47
 MOD_PIKK_1
 - -
0.65
 --

Substrate: p53 (Cellular tumor antigen p53)
Seq-ID: P10361 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
RNA polymerase II transcription factor activity,
ubiquitin protein ligase binding,
DNA strand annealing activity,
copper ion binding,
ATP binding,
zinc ion binding,
sequence-specific DNA binding transcription factor activity,
transcription repressor activity,
sequence-specific DNA binding,
protein C-terminus binding		 cytosol,
transcription factor complex,
nucleolus,
soluble fraction,
endoplasmic reticulum,
mitochondrion,
chromatin		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
response to amino acid stimulus,
response to oxidative stress,
response to drug,
response to vitamin B3,
cell cycle,
positive regulation of apoptosis,
negative regulation of smooth muscle cell proliferation,
response to cytokine stimulus,
response to X-ray,
response to tumor cell,
regulation of intracellular pH,
response to caffeine,
nucleotide-excision repair,
response to retinoic acid,
wound healing,
multicellular organismal development,
response to hyperoxia,
positive regulation of leukocyte migration,
response to metal ion,
response to UV,
transcription,
negative regulation of cell growth,
positive regulation of cell cycle,
activation of caspase activity by cytochrome c,
cell aging
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 15 QSDMSIELPLSQETFSCLWKL DNA-PK 7862459
LTP
1.00
 MOD_PIKK_1
 - P53_TAD
0.35
 - medium

Substrate: Protein kinase Cds1 (Protein serine/threonine kinase activity)
Seq-ID: Q98TW0 [Xenopus laevis]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding		 protein amino acid phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 39 SQSSSSGTLSSLDTVPVQDLA DNA-PK 15509799
LTP
1.00
 - -
0.50
 - medium

Substrate: Replication factor-A protein 2 (DNA binding protein)
Seq-ID: P15927 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-69732   LT_SV40
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
single-stranded DNA binding,
protein binding		 nucleoplasm,
DNA replication factor A complex		 nucleotide-excision repair, DNA damage removal,
nucleotide-excision repair, DNA gap filling,
DNA-dependent DNA replication,
DNA recombination
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 21 SSSYGGAGGYTQSPGGFGSPA DNA-PK 9295339
LTP
0.21
 MOD_PIKK_1
 - -
0.55
 --
T 21 SSSYGGAGGYTQSPGGFGSPA DNA-PK 9139719
LTP
0.21
 MOD_PIKK_1
 - -
0.55
 --
T 21 SSSYGGAGGYTQSPGGFGSPA DNA-PK 14872059
LTP
0.21
 MOD_PIKK_1
 - -
0.55
 --
S 33 SPGGFGSPAPSQAEKKSRARA DNA-PK 9295339
LTP
0.91
 MOD_PIKK_1
 - -
0.70
 --
S 33 SPGGFGSPAPSQAEKKSRARA DNA-PK 9139719
LTP
0.91
 MOD_PIKK_1
 - -
0.70
 --

Substrate: SRF (Serum response factor)
Seq-ID: P11831 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-15523   MYOD1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein homodimerization activity,
specific RNA polymerase II transcription factor activity,
transcription factor binding,
sequence-specific DNA binding transcription factor activity,
serum response element binding		 cytoplasm,
nucleus		 senescence,
transcription,
positive regulation of cell differentiation,
neuron development,
regulation of smooth muscle cell differentiation,
response to hormone stimulus,
response to toxin,
positive regulation of transcription via serum response element binding,
response to cytokine stimulus,
heart looping,
positive regulation of smooth muscle contraction,
cell migration involved in sprouting angiogenesis,
muscle cell homeostasis,
trophectodermal cell differentiation,
angiogenesis involved in wound healing,
positive regulation of transcription initiation from RNA polymerase II promoter
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 435 DGSLTVLNAFSQAPSTMQVSH DNA-PK 8407951
LTP
0.23
 MOD_PIKK_1
 - -
0.46
 --
S 446 QAPSTMQVSHSQVQEPGGVPQ DNA-PK 8407951
LTP
0.00
 MOD_PIKK_1
 - -
0.68
 --

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