List of substrates found:


Substrate: 60S acidic ribosomal protein P2 (Ribosomal subunit)
Seq-ID: P05387 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-48147   NEMO_HUMAN
MINT-48285   M3K1_HUMAN
MINT-48706   NFKB2_HUMAN
MINT-48796   M3K14_HUMAN
MINT-48985   RELB_HUMAN
MINT-3297185   1433Z_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
structural constituent of ribosome,
RNA binding		 cytosolic large ribosomal subunit translational elongation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 102 EEKKDEKKEESEESDDDMGFG GRK-2 12379128
LTP
0.79
 - Ribosomal_60s
0.84
 - medium
S 105 KDEKKEESEESDDDMGFGLFD GRK-2 12379128
LTP
0.53
 - Ribosomal_60s
0.77
 - medium

Substrate: Alpha-synuclein (Chaperone)
Seq-ID: P37840 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-2515544   VIME_HUMAN
MINT-3387974   TPPP_HUMAN
MINT-7555062   HSP71_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
histone binding,
ferrous iron binding,
phospholipase binding,
caspase inhibitor activity,
dynein binding,
alpha-tubulin binding,
zinc ion binding,
Hsp70 protein binding,
kinesin binding,
magnesium ion binding,
calcium ion binding,
tau protein binding		 plasma membrane,
cytosol,
nucleus,
axon,
actin cytoskeleton,
cell cortex,
growth cone,
fibril		 response to magnesium ion,
positive regulation of release of sequestered calcium ion into cytosol,
response to interferon-gamma,
regulation of phospholipase activity,
negative regulation of platelet-derived growth factor receptor signaling pathway,
positive regulation of inositol phosphate biosynthetic process,
response to interleukin-1,
response to iron(II) ion,
synaptic vesicle endocytosis,
negative regulation of monooxygenase activity,
positive regulation of receptor recycling,
response to lipopolysaccharide,
negative regulation of norepinephrine uptake,
negative regulation of exocytosis,
negative regulation of histone acetylation,
negative regulation of serotonin uptake,
receptor internalization,
cell death,
negative regulation of dopamine uptake,
negative regulation of transporter activity,
negative regulation of thrombin receptor signaling pathway,
positive regulation of endocytosis,
anti-apoptosis,
negative regulation of caspase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 129 DPDNEAYEMPSEEGYQDYEPE GRK-2 10852916
LTP
0.09
 - Synuclein
0.84
 --

Substrate: Beta-2 adrenergic receptor (Protein G coupled receptor)
Seq-ID: P07550 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-1796656   NHRF1_HUMAN
MINT-4051815   SRC_HUMAN
MINT-7291631   UBP33_HUMAN
MINT-7720120   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
potassium channel regulator activity,
protein homodimerization activity,
norepinephrine binding,
beta2-adrenergic receptor activity		 receptor complex,
endosome,
integral to plasma membrane,
lysosome		 positive regulation of MAPKKK cascade,
receptor-mediated endocytosis,
activation of transmembrane receptor protein tyrosine kinase activity,
endosome to lysosome transport,
desensitization of G-protein coupled receptor protein signaling pathway by arrestin
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 384 NKLLCEDLPGTEDFVGHQGTV GRK-2 8662852
LTP
0.67
 - -
0.31
 --
S 396 DFVGHQGTVPSDNIDSQGRNC GRK-2 8662852
LTP
0.08
 - -
0.50
 --
S 401 QGTVPSDNIDSQGRNCSTNDS GRK-2 8662852
LTP
0.24
 - -
0.53
 --
S 407 DNIDSQGRNCSTNDSLL     GRK-2 8662852
LTP
0.21
 - -
0.44
 --

Substrate: Delta-type opioid receptor (G protein coupled receptor)
Seq-ID: P41143 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-7889371   AT2A2_HUMAN
MINT-7889449   CALX_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
delta-opioid receptor activity,
protein binding		 integral to plasma membrane immune response,
protein import into nucleus, translocation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 358 AREATARERVTACTPSDGPGG GRK-2 11040053
LTP
0.00
 - -
0.48
 - low
T 361 ATARERVTACTPSDGPGGGAA GRK-2 11040053
LTP
0.13
 - -
0.47
 - low
S 363 ARERVTACTPSDGPGGGAAA  GRK-2 11040053
LTP
0.24
 - -
0.45
 - low

Substrate: Erzin (Connection of cytoscheletro structure to plasma membrane)
Seq-ID: P15311 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-73250   TB10A_HUMAN
MINT-73254   PLCB3_HUMAN
MINT-73256   NHRF1_HUMAN
MINT-3318887   1433Z_HUMAN
MINT-6380786   FES_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cell adhesion molecule binding,
actin filament binding		 filopodium,
cortical cytoskeleton,
actin filament,
cytosol,
ruffle membrane,
microvillus membrane,
extrinsic to membrane,
apical plasma membrane		 membrane to membrane docking,
regulation of cell shape,
actin filament bundle assembly,
cytoskeletal anchoring at plasma membrane,
leukocyte cell-cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 567 NMRQGRDKYKTLRQIRQGNTK GRK-2 15843435
LTP
0.95
 - ERM
0.76
 --

Substrate: FMLP receptor (G protein coupled receptor)
Seq-ID: P21462 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
N-formyl peptide receptor activity plasma membrane,
endosome,
integral to membrane		 nitric oxide mediated signal transduction,
cellular component movement,
activation of MAPK activity,
chemotaxis,
G-protein signaling, coupled to cAMP nucleotide second messenger
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 328 ASLERALTEDSTQTSDTATNS GRK-2 7836371
LTP
0.31
 - -
0.53
 - medium
T 329 SLERALTEDSTQTSDTATNST GRK-2 7836371
LTP
0.68
 - -
0.55
 - medium
T 331 ERALTEDSTQTSDTATNSTLP GRK-2 7836371
LTP
0.14
 - -
0.56
 - medium
S 332 RALTEDSTQTSDTATNSTLPS GRK-2 7836371
LTP
0.97
 - -
0.57
 - medium
T 334 LTEDSTQTSDTATNSTLPSAE GRK-2 7836371
LTP
0.15
 - -
0.56
 - medium
T 336 EDSTQTSDTATNSTLPSAEVA GRK-2 7836371
LTP
0.14
 - -
0.51
 - medium
S 338 STQTSDTATNSTLPSAEVALQ GRK-2 7836371
LTP
0.93
 - -
0.47
 - medium
T 339 TQTSDTATNSTLPSAEVALQA GRK-2 7836371
LTP
0.54
 - -
0.43
 - medium

Substrate: G-protein coupled receptor homolog US28 (Receptor for a C-C type chemokine)
Seq-ID: P69332 [Human herpesvirus 5 strain AD169]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
C-C chemokine receptor activity integral to membrane,
host cell plasma membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 323 LFSRDVSWYHSMSFSRRSSPS GRK-2 12668664
LTP
1.00
 - -
0.09
 - medium

Substrate: GMP-PDE gamma (Rod/cone cGMP-PDE gamma subunit family)
Seq-ID: P09174 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cGMP binding,
3`,5`-cyclic-nucleotide phosphodiesterase activity,
protein binding		 positive regulation of epidermal growth factor receptor signaling pathway,
visual perception,
activation of MAPK activity,
response to stimulus,
positive regulation of G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 62 DDIPGMEGLGTDITVICPWEA GRK-2 12624098
LTP
0.76
 - PDE6_gamma
0.37
 1FQJ 55.48%

Substrate: GMP-PDE gamma (Rod/cone cGMP-PDE gamma subunit family)
Seq-ID: P18545 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cGMP binding,
3`,5`-cyclic-nucleotide phosphodiesterase activity,
enzyme inhibitor activity		 visual perception,
response to stimulus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 62 DDIPGMEGLGTDITVICPWEA GRK-2 12624098
LTP
0.74
 - PDE6_gamma
0.37
 1FQJ 55.48%

Substrate: HRH1 (G-protein coupled receptor activity, histamine receptor activity)
Seq-ID: P35367 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
histamine receptor activity integral to plasma membrane inflammatory response,
activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 398 KFTWKRLRSHSRQYVSGLHMN GRK-2 15107581
LTP
1.00
 - 7tm_1
0.19
 - medium

Substrate: Melanocortin 4 receptor (G protein coupled receptor)
Seq-ID: P32245 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ubiquitin protein ligase binding,
neuropeptide binding,
melanocyte-stimulating hormone receptor activity		 plasma membrane,
integral to membrane		 positive regulation of cAMP biosynthetic process,
positive regulation of bone resorption,
feeding behavior,
G-protein signaling, coupled to cAMP nucleotide second messenger
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 329 CYPLGGLCDLSSRY        GRK-2 12639913
LTP
0.20
 - -
0.01
 - low
S 330 YPLGGLCDLSSRY         GRK-2 12639913
LTP
0.00
 - -
0.01
 - low

Substrate: PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID: P09619 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-2832596   NHRF2_HUMAN
MINT-2832984   PTEN_HUMAN
MINT-2833042   NHRF1_HUMAN
MINT-6762380   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
vascular endothelial growth factor receptor activity,
platelet-derived growth factor binding,
platelet activating factor receptor activity,
platelet-derived growth factor receptor binding,
ATP binding,
platelet-derived growth factor beta-receptor activity		 integral to plasma membrane positive regulation of cell proliferation,
positive regulation of cell migration,
protein amino acid autophosphorylation,
peptidyl-tyrosine phosphorylation,
cell chemotaxis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 1104 CPAPRAEAEDSFL         GRK-2 15271984
LTP
0.00
 - -
0.66
 - medium

Substrate: Tubulin beta-3 chain (Structural protein)
Seq-ID: Q13509 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-48464   M3K3_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
GTPase activity,
GTP binding,
structural molecule activity		 microtubule axon guidance,
protein polymerization,
microtubule-based movement
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 409 TGEGMDEMEFTEAESNMNDLV GRK-2 12631274
LTP
0.91
 - COIL
0.54
 - low
S 420 EAESNMNDLVSEYQQYQDATA GRK-2 12631274
LTP
0.87
 - COIL
0.55
 - low
S 444 GEMYEDDEEESEAQGPK     GRK-2 12631274
LTP
0.00
 - -
0.90
 - low

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