Click on substrate name for additional information.


Substrate: Alpha-synuclein (Chaperone)
Seq-ID: P37840 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-2515544   VIME_HUMAN
MINT-3387974   TPPP_HUMAN
MINT-7555062   HSP71_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
histone binding,
ferrous iron binding,
phospholipase binding,
caspase inhibitor activity,
dynein binding,
alpha-tubulin binding,
zinc ion binding,
Hsp70 protein binding,
kinesin binding,
magnesium ion binding,
calcium ion binding,
tau protein binding		 plasma membrane,
cytosol,
nucleus,
axon,
actin cytoskeleton,
cell cortex,
growth cone,
fibril		 response to magnesium ion,
positive regulation of release of sequestered calcium ion into cytosol,
response to interferon-gamma,
regulation of phospholipase activity,
negative regulation of platelet-derived growth factor receptor signaling pathway,
positive regulation of inositol phosphate biosynthetic process,
response to interleukin-1,
response to iron(II) ion,
synaptic vesicle endocytosis,
negative regulation of monooxygenase activity,
positive regulation of receptor recycling,
response to lipopolysaccharide,
negative regulation of norepinephrine uptake,
negative regulation of exocytosis,
negative regulation of histone acetylation,
negative regulation of serotonin uptake,
receptor internalization,
cell death,
negative regulation of dopamine uptake,
negative regulation of transporter activity,
negative regulation of thrombin receptor signaling pathway,
positive regulation of endocytosis,
anti-apoptosis,
negative regulation of caspase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 129 DPDNEAYEMPSEEGYQDYEPE GRK-5 10852916
LTP
0.09
 - Synuclein
0.84
 --

Substrate: Beta-2 adrenergic receptor (Protein G coupled receptor)
Seq-ID: P07550 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-1796656   NHRF1_HUMAN
MINT-4051815   SRC_HUMAN
MINT-7291631   UBP33_HUMAN
MINT-7720120   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
potassium channel regulator activity,
protein homodimerization activity,
norepinephrine binding,
beta2-adrenergic receptor activity		 receptor complex,
endosome,
integral to plasma membrane,
lysosome		 positive regulation of MAPKKK cascade,
receptor-mediated endocytosis,
activation of transmembrane receptor protein tyrosine kinase activity,
endosome to lysosome transport,
desensitization of G-protein coupled receptor protein signaling pathway by arrestin
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 384 NKLLCEDLPGTEDFVGHQGTV GRK-5 8662852
LTP
0.67
 - -
0.31
 --
T 393 GTEDFVGHQGTVPSDNIDSQG GRK-5 8662852
LTP
0.19
 - -
0.50
 --
S 396 DFVGHQGTVPSDNIDSQGRNC GRK-5 8662852
LTP
0.08
 - -
0.50
 --
S 401 QGTVPSDNIDSQGRNCSTNDS GRK-5 8662852
LTP
0.24
 - -
0.53
 --
S 407 DNIDSQGRNCSTNDSLL     GRK-5 8662852
LTP
0.21
 - -
0.44
 --
S 411 SQGRNCSTNDSLL         GRK-5 8662852
LTP
0.00
 - -
0.34
 --

Substrate: GRK5 (G protein-coupled receptor kinase GRK5 (EC 2.7.1.-) (from PhosphoBase))
Seq-ID: P34947 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase C binding,
G-protein coupled receptor kinase activity,
phospholipid binding,
ATP binding,
signal transducer activity		 plasma membrane,
cytoplasm,
soluble fraction		 protein amino acid phosphorylation,
tachykinin receptor signaling pathway,
regulation of G-protein coupled receptor protein signaling pathway,
G-protein signaling, coupled to cAMP nucleotide second messenger
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 484 CKDVLDIEQFSTVKGVNLDHT GRK-5 8144599
LTP
1.00
 - S_TK_X
0.33
 - medium
T 485 KDVLDIEQFSTVKGVNLDHTD GRK-5 8144599
LTP
0.98
 - S_TK_X
0.35
 - medium

Substrate: GRK5 (G protein-coupled receptor kinase GRK5 (EC 2.7.1.-) (from PhosphoBase))
Seq-ID: P43249 [Bos taurus]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
G-protein coupled receptor kinase activity,
ATP binding,
signal transducer activity		 protein amino acid phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 484 CKDVLDIEQFSTVKGVNLDHT GRK-5 8120045
LTP
1.00
 - S_TK_X
0.33
 - medium
T 485 KDVLDIEQFSTVKGVNLDHTD GRK-5 8120045
LTP
0.98
 - S_TK_X
0.35
 - medium

Valid HTML 4.01 Transitional