List of substrates found:


Substrate: Alpha-1B adrenergic receptor (alpha-1B adrenergic receptor (from PhosphoBase))
Seq-ID: P15823 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
alpha1-adrenergic receptor activity plasma membrane,
membrane fraction,
integral to membrane		 negative regulation of Rho protein signal transduction,
response to estrogen stimulus,
response to drug,
elevation of cytosolic calcium ion concentration
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 404 SLERSQSRKDSLDDSGSCMSG GRK_group 9353340
LTP
0.21
 - -
0.55
 - medium
S 408 SQSRKDSLDDSGSCMSGTQRT GRK_group 9353340
LTP
0.42
 - -
0.58
 - medium
S 410 SRKDSLDDSGSCMSGTQRTLP GRK_group 9353340
LTP
0.64
 - -
0.58
 - medium

Substrate: Beta-2 adrenergic receptor (Protein G coupled receptor)
Seq-ID: P04274 [Mesocricetus auratus]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein homodimerization activity,
norepinephrine binding,
beta2-adrenergic receptor activity		 plasma membrane,
receptor complex,
integral to membrane		 positive regulation of MAPKKK cascade,
receptor-mediated endocytosis,
activation of adenylate cyclase activity,
desensitization of G-protein coupled receptor protein signaling pathway by arrestin
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 369 NGKTDYMGEASGCQLGQEKES GRK_group 8132675
LTP
0.16
 - -
0.42
 - medium
S 379 SGCQLGQEKESERLCEDPPGT GRK_group 8132675
LTP
0.72
 - -
0.46
 - medium
T 389 SERLCEDPPGTESFVNCQGTV GRK_group 8132675
LTP
0.45
 - -
0.37
 - medium
S 391 RLCEDPPGTESFVNCQGTVPS GRK_group 8132675
LTP
0.23
 - -
0.35
 - medium
S 406 QGTVPSLSLDSQGRNCSTNDS GRK_group 8132675
LTP
0.44
 - -
0.43
 - medium
S 412 LSLDSQGRNCSTNDSPL     GRK_group 8132675
LTP
0.44
 - -
0.48
 - medium
T 413 SLDSQGRNCSTNDSPL      GRK_group 8132675
LTP
0.93
 - -
0.49
 - medium
S 416 SQGRNCSTNDSPL         GRK_group 8132675
LTP
0.00
 - -
0.44
 - medium

Substrate: Beta-2 adrenergic receptor (Protein G coupled receptor)
Seq-ID: P07550 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-1796656   NHRF1_HUMAN
MINT-4051815   SRC_HUMAN
MINT-7291631   UBP33_HUMAN
MINT-7720120   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
potassium channel regulator activity,
protein homodimerization activity,
norepinephrine binding,
beta2-adrenergic receptor activity		 receptor complex,
endosome,
integral to plasma membrane,
lysosome		 positive regulation of MAPKKK cascade,
receptor-mediated endocytosis,
activation of transmembrane receptor protein tyrosine kinase activity,
endosome to lysosome transport,
desensitization of G-protein coupled receptor protein signaling pathway by arrestin
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 355 SSLKAYGNGYSSNGNTGEQSG GRK_group 14722251
LTP
0.13
 - -
0.42
 --
S 356 SLKAYGNGYSSNGNTGEQSGY GRK_group 14722251
LTP
0.04
 - -
0.42
 --

Substrate: CCR5 (Cell surface receptor)
Seq-ID: P51681 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
C-C chemokine receptor activity,
phosphoinositide phospholipase C activity,
coreceptor activity,
actin binding		 external side of plasma membrane,
endosome,
integral to plasma membrane		 cellular defense response,
immune response,
inflammatory response,
cell-cell signaling,
chemotaxis,
initiation of viral infection,
interspecies interaction between organisms,
elevation of cytosolic calcium ion concentration
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 336 IFQQEAPERASSVYTRSTGEQ GRK_group 10085131
LTP
0.93
 - -
0.29
 - low
S 336 IFQQEAPERASSVYTRSTGEQ GRK_group 12403770
LTP
0.93
 - -
0.29
 - low
S 337 FQQEAPERASSVYTRSTGEQE GRK_group 10085131
LTP
0.97
 - -
0.32
 - low
S 342 PERASSVYTRSTGEQEISVGL GRK_group 10085131
LTP
0.95
 - -
0.27
 - low
S 349 YTRSTGEQEISVGL        GRK_group 10085131
LTP
0.95
 - -
0.25
 - low

Substrate: Melanocortin 4 receptor (G protein coupled receptor)
Seq-ID: P32245 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ubiquitin protein ligase binding,
neuropeptide binding,
melanocyte-stimulating hormone receptor activity		 plasma membrane,
integral to membrane		 positive regulation of cAMP biosynthetic process,
positive regulation of bone resorption,
feeding behavior,
G-protein signaling, coupled to cAMP nucleotide second messenger
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 312 YALRSQELRKTFKEIICCYPL GRK_group 12639913
LTP
1.00
 MOD_PKA_2
 - 7TM_GPCR_Srsx
0.01
 - low
S 329 CYPLGGLCDLSSRY        GRK_group 12639913
LTP
0.20
 - -
0.01
 - low
S 330 YPLGGLCDLSSRY         GRK_group 12639913
LTP
0.00
 - -
0.01
 - low

Substrate: Muscarinic acetylcholine receptor M2 (muscarinic acetylcholine receptor M2 (from PhosphoBase))
Seq-ID: P08172 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
muscarinic acetylcholine receptor activity,
protein binding		 cell junction,
integral to plasma membrane,
postsynaptic membrane		 nervous system development,
activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway,
regulation of heart contraction,
G-protein signaling, coupled to cAMP nucleotide second messenger,
response to virus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 232 KEPVANQDPVSPSLVQGRIVK GRK_group 8132675
LTP
0.44
 - 7tm_1
0.54
 - medium
S 234 PVANQDPVSPSLVQGRIVKPN GRK_group 8132675
LTP
0.55
 - 7tm_1
0.56
 - medium
S 250 IVKPNNNNMPSSDDGLEHNKI GRK_group 8132675
LTP
0.44
 - 7tm_1
0.76
 - medium
S 251 VKPNNNNMPSSDDGLEHNKIQ GRK_group 8132675
LTP
0.72
 - 7tm_1
0.76
 - medium
T 271 QNGKAPRDPVTENCVQGEEKE GRK_group 8132675
LTP
0.46
 - 7tm_1
0.77
 - medium
S 282 ENCVQGEEKESSNDSTSVSAV GRK_group 8132675
LTP
0.91
 - 7tm_1
0.71
 - medium
S 283 NCVQGEEKESSNDSTSVSAVA GRK_group 8132675
LTP
1.00
 - 7tm_1
0.72
 - medium
S 286 QGEEKESSNDSTSVSAVASNM GRK_group 8132675
LTP
0.97
 - 7tm_1
0.77
 - medium
T 287 GEEKESSNDSTSVSAVASNMR GRK_group 8132675
LTP
0.21
 - 7tm_1
0.79
 - medium
S 288 EEKESSNDSTSVSAVASNMRD GRK_group 8132675
LTP
0.33
 - 7tm_1
0.80
 - medium
S 290 KESSNDSTSVSAVASNMRDDE GRK_group 8132675
LTP
0.96
 - 7tm_1
0.79
 - medium
S 294 NDSTSVSAVASNMRDDEITQD GRK_group 8132675
LTP
0.59
 - 7tm_1
0.76
 - medium
T 302 VASNMRDDEITQDENTVSTSL GRK_group 8132675
LTP
0.17
 - 7tm_1
0.76
 - medium
T 307 RDDEITQDENTVSTSLGHSKD GRK_group 8132675
LTP
0.18
 - 7tm_1
0.80
 - medium
S 309 DEITQDENTVSTSLGHSKDEN GRK_group 8132675
LTP
0.47
 - 7tm_1
0.81
 - medium
T 310 EITQDENTVSTSLGHSKDENS GRK_group 8132675
LTP
0.45
 - 7tm_1
0.80
 - medium
S 311 ITQDENTVSTSLGHSKDENSK GRK_group 8132675
LTP
0.34
 - 7tm_1
0.78
 - medium

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