List of substrates found:


Substrate: Beta-2 adrenergic receptor (Protein G coupled receptor)
Seq-ID: P04274 [Mesocricetus auratus]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 132 ETLCVIAVDRYIAITSPFKYQ IGF1R 8910597
LTP
1.00
- 7tm_1
0.01
- medium

Substrate: Beta-2 adrenergic receptor (Protein G coupled receptor)
Seq-ID: P07550 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 132 ETLCVIAVDRYFAITSPFKYQ IGF1R 8910597
LTP
1.00
- 7tm_1
0.01
2R4R 24.02%
Y 141 RYFAITSPFKYQSLLTKNKAR IGF1R 8910597
LTP
1.00
- 7tm_1
0.01
2R4R 13.10%

Substrate: Crk (The Crk protein contains a single SH2 and two SH3 domains in the order SH2-SH3-SH3)
Seq-ID: Q64010 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein phosphorylated amino acid binding,
SH3/SH2 adaptor activity
plasma membrane,
cytoplasm
Conservation:

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Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 221 QPLGGPEPGPYAQPSVNTPLP IGF1R 9480911
LTP
0.31
- -
0.84
--

Substrate: IGF1-R (Receptor tyrosine kinase)
Seq-ID: P08069 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 973 NNSRLGNGVLYASVNPEYFSA IGF1R 8550552
LTP
1.00
CRK SH2;
Csk SH2
-
0.16
--
Y 973 NNSRLGNGVLYASVNPEYFSA IGF1R 8940173
LTP
1.00
CRK SH2;
Csk SH2
-
0.16
--
Y 980 GVLYASVNPEYFSAADVYVPD IGF1R 8550552
LTP
1.00
CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB
-
0.07
1P4O 89.96%
Y 980 GVLYASVNPEYFSAADVYVPD IGF1R 8940173
LTP
1.00
CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB
-
0.07
1P4O 89.96%
Y 1161 IGDFGMTRDIYETDYYRKGGK IGF1R 8550552
LTP
1.00
PTPN11 SH2 TyrKc
0.16
1P4O 3.49%
Y 1161 IGDFGMTRDIYETDYYRKGGK IGF1R 8940173
LTP
1.00
PTPN11 SH2 TyrKc
0.16
1P4O 3.49%
Y 1165 GMTRDIYETDYYRKGGKGLLP IGF1R 8550552
LTP
1.00
PTPN11 SH2 TyrKc
0.16
1P4O 17.03%
Y 1165 GMTRDIYETDYYRKGGKGLLP IGF1R 8940173
LTP
1.00
PTPN11 SH2 TyrKc
0.16
1P4O 17.03%
Y 1166 MTRDIYETDYYRKGGKGLLPV IGF1R 8550552
LTP
1.00
PTPN11 SH2 TyrKc
0.14
1P4O 24.45%
Y 1166 MTRDIYETDYYRKGGKGLLPV IGF1R 8940173
LTP
1.00
PTPN11 SH2 TyrKc
0.14
1P4O 24.45%
Y 1280 MEPGFREVSFYYSEENKLPEP IGF1R 8940173
LTP
0.28
- -
0.44
1P4O 14.41%
Y 1281 EPGFREVSFYYSEENKLPEPE IGF1R 8550552
LTP
1.00
- -
0.43
1P4O 29.26%
Y 1346 LRASFDERQPYAHMNGGRKNE IGF1R 8550552
LTP
1.00
Csk SH2;
GRB10 SH2;
PIK3R1 SH2;
PTPN11 SH2
-
0.63
--

Substrate: IGF1-R (Receptor tyrosine kinase)
Seq-ID: Q60751 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 974 NNSRLGNGVLYASVNPEYFSA IGF1R 8940173
LTP
1.00
- -
0.17
- medium
Y 974 NNSRLGNGVLYASVNPEYFSA IGF1R 9480911
LTP
1.00
- -
0.17
- medium
Y 981 GVLYASVNPEYFSAADVYVPD IGF1R 8940173
LTP
1.00
- -
0.07
- medium
Y 981 GVLYASVNPEYFSAADVYVPD IGF1R 9480911
LTP
1.00
- -
0.07
- medium
Y 1163 IGDFGMTRDIYETDYYRKGGK IGF1R 8940173
LTP
1.00
- TyrKc
0.16
- medium
Y 1167 GMTRDIYETDYYRKGGKGLLP IGF1R 8940173
LTP
1.00
- TyrKc
0.15
- medium
Y 1168 MTRDIYETDYYRKGGKGLLPV IGF1R 8940173
LTP
1.00
- TyrKc
0.14
- medium
Y 1352 LRASFDERQPYAHMNGGRANE IGF1R 8940173
LTP
1.00
- -
0.66
- medium

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35570 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 608 DSSNLHTDDGYMPMSPGVAPV IGF1R 11572799
LTP
1.00
PIK3R1 SH2 -
0.79
- medium
Y 628 VPSNRKGNGDYMPMSPKSVSA IGF1R 11572799
LTP
1.00
PIK3R1 SH2 -
0.81
- medium
Y 658 RHPQRVDPNGYMMMSPSGSCS IGF1R 11572799
LTP
1.00
- -
0.72
- medium
Y 727 GGKLLPCTGDYMNMSPVGDSN IGF1R 11572799
LTP
1.00
- -
0.60
- medium
Y 895 HPPEPKSPGEYVNIEFGSGQP IGF1R 8530377
LTP
1.00
GRB2 SH2 -
0.80
- medium
Y 939 APREETGSEEYMNMDLGPGRR IGF1R 11572799
LTP
1.00
PIK3R1 SH2 -
0.87
- medium
Y 987 TRSVPNSRGDYMTMQIGCPRQ IGF1R 11572799
LTP
0.16
- -
0.64
- medium
Y 1172 AAGGLEKSLNYIDLDLVKDVK IGF1R 11572799
LTP
1.00
PTPN11 SH2 -
0.48
- medium

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