List of substrates found:


Substrate: Beta-2 adrenergic receptor (Protein G coupled receptor)
Seq-ID: P04274 [Mesocricetus auratus]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein homodimerization activity,
norepinephrine binding,
beta2-adrenergic receptor activity		 plasma membrane,
receptor complex,
integral to membrane		 positive regulation of MAPKKK cascade,
receptor-mediated endocytosis,
activation of adenylate cyclase activity,
desensitization of G-protein coupled receptor protein signaling pathway by arrestin
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 132 ETLCVIAVDRYIAITSPFKYQ IGF1R 8910597
LTP
1.00
 - 7tm_1
0.01
 - medium

Substrate: Beta-2 adrenergic receptor (Protein G coupled receptor)
Seq-ID: P07550 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-1796656   NHRF1_HUMAN
MINT-4051815   SRC_HUMAN
MINT-7291631   UBP33_HUMAN
MINT-7720120   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
potassium channel regulator activity,
protein homodimerization activity,
norepinephrine binding,
beta2-adrenergic receptor activity		 receptor complex,
endosome,
integral to plasma membrane,
lysosome		 positive regulation of MAPKKK cascade,
receptor-mediated endocytosis,
activation of transmembrane receptor protein tyrosine kinase activity,
endosome to lysosome transport,
desensitization of G-protein coupled receptor protein signaling pathway by arrestin
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 132 ETLCVIAVDRYFAITSPFKYQ IGF1R 8910597
LTP
1.00
 - 7tm_1
0.01
 2R4R 24.02%
Y 141 RYFAITSPFKYQSLLTKNKAR IGF1R 8910597
LTP
1.00
 - 7tm_1
0.01
 2R4R 13.10%

Substrate: Crk (The Crk protein contains a single SH2 and two SH3 domains in the order SH2-SH3-SH3)
Seq-ID: Q64010 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein phosphorylated amino acid binding,
SH3/SH2 adaptor activity		 plasma membrane,
cytoplasm
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 221 QPLGGPEPGPYAQPSVNTPLP IGF1R 9480911
LTP
0.31
 - -
0.84
 --

Substrate: IGF1-R (Receptor tyrosine kinase)
Seq-ID: P08069 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15644   GRB10_HUMAN
MINT-18053   IRS2_HUMAN
MINT-1774754   ARHGC_MOUSE
MINT-1774976   ARHGC_HUMAN
MINT-6800783   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
identical protein binding,
insulin-like growth factor receptor activity,
insulin binding,
metal ion binding,
insulin receptor binding,
insulin receptor substrate binding,
ATP binding,
insulin-like growth factor I binding		 microsome,
integral to plasma membrane		 positive regulation of DNA replication,
positive regulation of cell proliferation,
positive regulation of cell migration,
anti-apoptosis,
phosphoinositide 3-kinase cascade,
phosphoinositide-mediated signaling,
immune response,
protein amino acid autophosphorylation,
insulin receptor signaling pathway,
protein tetramerization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 973 NNSRLGNGVLYASVNPEYFSA IGF1R 8550552
LTP
1.00
 CRK SH2;
Csk SH2		 -
0.16
 --
Y 973 NNSRLGNGVLYASVNPEYFSA IGF1R 8940173
LTP
1.00
 CRK SH2;
Csk SH2		 -
0.16
 --
Y 980 GVLYASVNPEYFSAADVYVPD IGF1R 8550552
LTP
1.00
 CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB		 -
0.07
 1P4O 89.96%
Y 980 GVLYASVNPEYFSAADVYVPD IGF1R 8940173
LTP
1.00
 CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB		 -
0.07
 1P4O 89.96%
Y 1161 IGDFGMTRDIYETDYYRKGGK IGF1R 8550552
LTP
1.00
 PTPN11 SH2 TyrKc
0.16
 1P4O 3.49%
Y 1161 IGDFGMTRDIYETDYYRKGGK IGF1R 8940173
LTP
1.00
 PTPN11 SH2 TyrKc
0.16
 1P4O 3.49%
Y 1165 GMTRDIYETDYYRKGGKGLLP IGF1R 8550552
LTP
1.00
 PTPN11 SH2 TyrKc
0.16
 1P4O 17.03%
Y 1165 GMTRDIYETDYYRKGGKGLLP IGF1R 8940173
LTP
1.00
 PTPN11 SH2 TyrKc
0.16
 1P4O 17.03%
Y 1166 MTRDIYETDYYRKGGKGLLPV IGF1R 8550552
LTP
1.00
 PTPN11 SH2 TyrKc
0.14
 1P4O 24.45%
Y 1166 MTRDIYETDYYRKGGKGLLPV IGF1R 8940173
LTP
1.00
 PTPN11 SH2 TyrKc
0.14
 1P4O 24.45%
Y 1280 MEPGFREVSFYYSEENKLPEP IGF1R 8940173
LTP
0.28
 - -
0.44
 1P4O 14.41%
Y 1281 EPGFREVSFYYSEENKLPEPE IGF1R 8550552
LTP
1.00
 - -
0.43
 1P4O 29.26%
Y 1346 LRASFDERQPYAHMNGGRKNE IGF1R 8550552
LTP
1.00
 Csk SH2;
GRB10 SH2;
PIK3R1 SH2;
PTPN11 SH2		 -
0.63
 --

Substrate: IGF1-R (Receptor tyrosine kinase)
Seq-ID: Q60751 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-73467   GRB10_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
insulin-like growth factor receptor activity,
metal ion binding,
insulin receptor substrate binding,
ATP binding		 integral to membrane brain development,
positive regulation of MAPKKK cascade,
exocrine pancreas development,
prostate gland epithelium morphogenesis,
positive regulation of protein kinase B signaling cascade,
negative regulation of MAPKKK cascade,
protein amino acid autophosphorylation,
mammary gland development,
protein tetramerization,
male sex determination,
negative regulation of protein kinase B signaling cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 974 NNSRLGNGVLYASVNPEYFSA IGF1R 8940173
LTP
1.00
 - -
0.17
 - medium
Y 974 NNSRLGNGVLYASVNPEYFSA IGF1R 9480911
LTP
1.00
 - -
0.17
 - medium
Y 981 GVLYASVNPEYFSAADVYVPD IGF1R 8940173
LTP
1.00
 - -
0.07
 - medium
Y 981 GVLYASVNPEYFSAADVYVPD IGF1R 9480911
LTP
1.00
 - -
0.07
 - medium
Y 1163 IGDFGMTRDIYETDYYRKGGK IGF1R 8940173
LTP
1.00
 - TyrKc
0.16
 - medium
Y 1167 GMTRDIYETDYYRKGGKGLLP IGF1R 8940173
LTP
1.00
 - TyrKc
0.15
 - medium
Y 1168 MTRDIYETDYYRKGGKGLLPV IGF1R 8940173
LTP
1.00
 - TyrKc
0.14
 - medium
Y 1352 LRASFDERQPYAHMNGGRANE IGF1R 8940173
LTP
1.00
 - -
0.66
 - medium

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35570 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-45938   ITB2_HUMAN
MINT-45939   ITB3_HUMAN
MINT-60761   INSR_RAT
MINT-6762786   GRB2_HUMAN
MINT-6762811   PTN11_HUMAN
MINT-6762830   PTPRA_HUMAN
MINT-6762866   PTN1_HUMAN
MINT-6762880   P85A_HUMAN
MINT-6762904   CRK_HUMAN
MINT-6795115   INSR_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
protein kinase C binding,
insulin-like growth factor receptor binding,
insulin-like growth factor receptor activity,
insulin receptor binding,
transmembrane receptor protein tyrosine kinase docking protein activity,
SH2 domain binding		 microsome,
cytosol,
insulin receptor complex,
nucleus		 negative regulation of insulin receptor signaling pathway,
negative regulation of somatostatin secretion,
positive regulation of insulin receptor signaling pathway,
negative regulation of insulin secretion,
protein heterooligomerization,
insulin receptor signaling pathway,
positive regulation of phosphoinositide 3-kinase activity,
positive regulation of phosphorylation,
positive regulation of glucagon secretion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 608 DSSNLHTDDGYMPMSPGVAPV IGF1R 11572799
LTP
1.00
 PIK3R1 SH2 -
0.79
 - medium
Y 628 VPSNRKGNGDYMPMSPKSVSA IGF1R 11572799
LTP
1.00
 PIK3R1 SH2 -
0.81
 - medium
Y 658 RHPQRVDPNGYMMMSPSGSCS IGF1R 11572799
LTP
1.00
 - -
0.72
 - medium
Y 727 GGKLLPCTGDYMNMSPVGDSN IGF1R 11572799
LTP
1.00
 - -
0.60
 - medium
Y 895 HPPEPKSPGEYVNIEFGSGQP IGF1R 8530377
LTP
1.00
 GRB2 SH2 -
0.80
 - medium
Y 939 APREETGSEEYMNMDLGPGRR IGF1R 11572799
LTP
1.00
 PIK3R1 SH2 -
0.87
 - medium
Y 987 TRSVPNSRGDYMTMQIGCPRQ IGF1R 11572799
LTP
0.16
 - -
0.64
 - medium
Y 1172 AAGGLEKSLNYIDLDLVKDVK IGF1R 11572799
LTP
1.00
 PTPN11 SH2 -
0.48
 - medium

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