List of substrates found:


Substrate: Cyclin D1 (Cyclin D1)
Seq-ID: P24385 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-50433   CDK4_HUMAN
MINT-50434   CDK6_HUMAN
MINT-50435   MCM10_HUMAN
MINT-50437   CDN1A_HUMAN
MINT-7033534   CDK4_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase binding cytosol,
cyclin-dependent protein kinase holoenzyme complex,
nucleoplasm		 positive regulation of protein amino acid phosphorylation,
cell division,
response to UV-A,
mitotic cell cycle G1/S DNA damage checkpoint,
G1/S transition of mitotic cell cycle,
response to drug,
positive regulation of cyclin-dependent protein kinase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 286 EEEEEVDLACTPTDVRDVDI  IKK_alpha 16103118
LTP
0.98
 - -
0.49
 --

Substrate: Nuclear factor NF-kappa-B p100 subunit (Transcription factor)
Seq-ID: Q00653 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-47914   M3K8_HUMAN
MINT-48691   AIFM1_HUMAN
MINT-48692   NEMO_HUMAN
MINT-48693   HS71L_HUMAN
MINT-48694   GRP78_HUMAN
MINT-48695   U5S1_HUMAN
MINT-48696   HSP7C_HUMAN
MINT-48698   MBB1A_HUMAN
MINT-48699   IKKA_HUMAN
MINT-48700   ILF2_HUMAN
MINT-48701   GRP75_HUMAN
MINT-48702   PRP8_HUMAN
MINT-48703   SYMC_HUMAN
MINT-48705   RS10_HUMAN
MINT-48706   RLA2_HUMAN
MINT-48707   IQGA1_HUMAN
MINT-48709   RS3_HUMAN
MINT-48711   DNJA1_HUMAN
MINT-48712   SYIC_HUMAN
MINT-48714   SYEP_HUMAN
MINT-48715   PABP1_HUMAN
MINT-48716   EF1A2_HUMAN
MINT-48717   DDX21_HUMAN
MINT-48719   MATR3_HUMAN
MINT-48721   IKBA_HUMAN
MINT-48722   IKBB_HUMAN
MINT-48723   PYR1_HUMAN
MINT-48724   NFKB1_HUMAN
MINT-48727   CLH1_HUMAN
MINT-48728   IKKB_HUMAN
MINT-48730   RS14_HUMAN
MINT-48731   FAS_HUMAN
MINT-48732   GEMI4_HUMAN
MINT-48733   REL_HUMAN
MINT-48734   RL7_HUMAN
MINT-48735   ECHA_HUMAN
MINT-48737   TBB6_HUMAN
MINT-48738   CALM_HUMAN
MINT-48739   TBB5_HUMAN
MINT-48741   TF3C1_HUMAN
MINT-48742   TBB4_HUMAN
MINT-48744   K1967_HUMAN
MINT-48747   DNJA3_HUMAN
MINT-48748   HNRPU_HUMAN
MINT-48749   DDX3X_HUMAN
MINT-48750   DHX9_HUMAN
MINT-48751   RL18_HUMAN
MINT-48754   RS8_HUMAN
MINT-48755   HNRPC_HUMAN
MINT-48756   SFPQ_HUMAN
MINT-48757   PARP1_HUMAN
MINT-48759   GTF2I_HUMAN
MINT-48760   HS90A_HUMAN
MINT-48761   NUCL_HUMAN
MINT-48762   PRKDC_HUMAN
MINT-48767   RL30_HUMAN
MINT-48768   RS3A_HUMAN
MINT-48770   HNRPM_HUMAN
MINT-48772   H2B1B_HUMAN
MINT-48774   KU86_HUMAN
MINT-48775   USP9X_HUMAN
MINT-48777   RS13_HUMAN
MINT-48780   RS27_HUMAN
MINT-49015   RELB_HUMAN
MINT-6804719   SUMO1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription coactivator activity,
sequence-specific DNA binding transcription factor activity		 Bcl3/NF-kappaB2 complex,
cytoplasm,
nucleus		 transcription,
signal transduction,
regulation of transcription, DNA-dependent
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 872 VKEDSAYGSQSVEQEAEKLGP IKK_alpha 15310758
LTP
0.20
 - -
0.81
 --

Substrate: Nuclear factor NF-kappa-B p105 subunit (Nuclear factor NF-kappa-B p105 subunit)
Seq-ID: P19838 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-47827   M3K8_HUMAN
MINT-47861   IKBB_HUMAN
MINT-48545   TPR_HUMAN
MINT-48546   KCRB_HUMAN
MINT-48547   CLH1_HUMAN
MINT-48555   VIME_HUMAN
MINT-48556   ADT3_HUMAN
MINT-48557   DESP_HUMAN
MINT-48560   JIP4_HUMAN
MINT-48561   COPB2_HUMAN
MINT-48636   BAG2_HUMAN
MINT-48638   NEMO_HUMAN
MINT-48639   HS71L_HUMAN
MINT-48640   GRP78_HUMAN
MINT-48641   HSP7C_HUMAN
MINT-48642   HNRPF_HUMAN
MINT-48643   IKKA_HUMAN
MINT-48644   ADT2_HUMAN
MINT-48645   GRP75_HUMAN
MINT-48646   RUVB2_HUMAN
MINT-48648   IMA3_HUMAN
MINT-48650   DNJA1_HUMAN
MINT-48651   IMA4_HUMAN
MINT-48653   C1QBP_HUMAN
MINT-48654   EF1A2_HUMAN
MINT-48655   MATR3_HUMAN
MINT-48656   IKBA_HUMAN
MINT-48659   MYH10_HUMAN
MINT-48660   PYR1_HUMAN
MINT-48663   ACTG_HUMAN
MINT-48665   STUB1_HUMAN
MINT-48666   REL_HUMAN
MINT-48669   TBB6_HUMAN
MINT-48670   CALM_HUMAN
MINT-48671   NONO_HUMAN
MINT-48672   TBB5_HUMAN
MINT-48673   TBB4_HUMAN
MINT-48675   K1967_HUMAN
MINT-48677   DNJA3_HUMAN
MINT-48678   MYH9_HUMAN
MINT-48679   RS8_HUMAN
MINT-48680   SFPQ_HUMAN
MINT-48682   HS90A_HUMAN
MINT-48684   PRKDC_HUMAN
MINT-48685   MYL6_HUMAN
MINT-48687   HNRPM_HUMAN
MINT-48688   HS90B_HUMAN
MINT-48689   ML12A_HUMAN
MINT-48724   NFKB2_HUMAN
MINT-48996   RELB_HUMAN
MINT-50169   HDAC1_HUMAN
MINT-7023862   CTNB1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
promoter binding,
sequence-specific DNA binding transcription factor activity,
protein binding		 cytosol,
I-kappaB/NF-kappaB complex,
nucleoplasm		 negative regulation of gene-specific transcription from RNA polymerase II promoter,
transcription from RNA polymerase II promoter,
positive regulation of transcription,
negative regulation of cellular protein metabolic process,
apoptosis,
anti-apoptosis,
negative regulation of cholesterol transport,
membrane protein intracellular domain proteolysis,
positive regulation of lipid storage,
signal transduction,
inflammatory response,
positive regulation of macrophage derived foam cell differentiation,
negative regulation of vitamin D biosynthetic process,
negative regulation of calcidiol 1-monooxygenase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 923 QQIDELRDSDSVCDSGVETSF IKK_alpha 11158290
LTP
0.09
 - -
0.49
 --
S 923 QQIDELRDSDSVCDSGVETSF IKK_alpha 10469655
LTP
0.09
 - -
0.49
 --
S 927 ELRDSDSVCDSGVETSFRKLS IKK_alpha 11158290
LTP
1.00
 - -
0.41
 --
S 927 ELRDSDSVCDSGVETSFRKLS IKK_alpha 12482991
LTP
1.00
 - -
0.41
 --
S 927 ELRDSDSVCDSGVETSFRKLS IKK_alpha 10469655
LTP
1.00
 - -
0.41
 --

Substrate: Nuclear receptor corepressor 2 (Transcription regulatory protein)
Seq-ID: Q9Y618 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15842   PPARA_HUMAN
MINT-4788120   PRGR_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
transcription corepressor activity,
histone deacetylase binding,
Notch binding,
protein N-terminus binding		 nuclear body,
transcriptional repressor complex		 negative regulation of gene-specific transcription from RNA polymerase II promoter,
transcription
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 2410 GGKAKVSGRPSSRKAKSPAPG IKK_alpha 15494311
LTP
0.87
 - -
0.84
 - medium

Substrate: p65 (Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit), RelA)
Seq-ID: Q04206 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-50016   IKBA_MOUSE
MINT-50017   IKBB_MOUSE
MINT-50025   KAPCA_HUMAN
MINT-50073   KS6A5_HUMAN
MINT-50084   KPCZ_HUMAN
MINT-50090   CSK21_HUMAN
MINT-50107   IKKA_HUMAN
MINT-50167   IKKB_HUMAN
MINT-50171   HDAC1_HUMAN
MINT-50175   KAT2B_HUMAN
MINT-50178   EP300_HUMAN
MINT-50179   HDAC3_HUMAN
MINT-58638   NCF1_HUMAN
MINT-62399   TF2B_HUMAN
MINT-2834593   NCOA3_HUMAN
MINT-6166971   OGT1_HUMAN
MINT-7235700   ASPP2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription repressor activity,
transcription repressor binding,
identical protein binding,
protein kinase binding,
ubiquitin protein ligase binding,
transcription activator binding,
transcription activator activity,
RNA polymerase II transcription factor activity, enhancer binding,
promoter binding,
protein N-terminus binding,
phosphate binding,
NF-kappaB binding		 cytosol,
transcription factor complex		 transcription,
positive regulation of I-kappaB kinase/NF-kappaB cascade,
cytokine-mediated signaling pathway,
anti-apoptosis,
defense response to virus,
membrane protein intracellular domain proteolysis,
cellular defense response,
inflammatory response,
nucleotide-binding oligomerization domain containing 2 signaling pathway,
response to interleukin-1,
interspecies interaction between organisms,
positive regulation of NF-kappaB transcription factor activity,
positive regulation of transcription from RNA polymerase II promoter,
response to UV-B,
negative regulation of gene-specific transcription
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 536 GLLSGDEDFSSIADMDFSALL IKK_alpha 15489227
LTP
0.93
 - -
0.35
 --

Substrate: p65 (Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit), RelA)
Seq-ID: Q04207 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19530   IKBA_MOUSE
MINT-19560   IKBB_MOUSE
MINT-7288484   UBIQ_MOUSE
MINT-7288511   CUL2_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription activator activity,
RNA polymerase II transcription factor activity, enhancer binding,
chromatin binding		 cytosol transcription,
organ morphogenesis,
negative regulation of protein catabolic process,
hair follicle development,
liver development,
positive regulation of interleukin-12 biosynthetic process,
response to muramyl dipeptide
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 534 NGLSGDEDFSSIADMDFSALL IKK_alpha 15858576
LTP
0.21
 - -
0.40
 --
S 534 NGLSGDEDFSSIADMDFSALL IKK_alpha 16135789
LTP
0.21
 - -
0.40
 --

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