List of substrates found:


Substrate: IKB-alpha (Major histocompatibility complex enhancer-binding protein MAD3)
Seq-ID: P25963 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-47837   REL_HUMAN
MINT-47839   IKBB_HUMAN
MINT-47840   ELP1_HUMAN
MINT-47841   IKKA_HUMAN
MINT-47842   IKKB_HUMAN
MINT-47843   NEMO_HUMAN
MINT-47845   MCM7_HUMAN
MINT-48656   NFKB1_HUMAN
MINT-48721   NFKB2_HUMAN
MINT-48993   RELB_HUMAN
MINT-64895   MED19_HUMAN
MINT-6762163   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
nuclear localization sequence binding,
identical protein binding,
ubiquitin protein ligase binding,
NF-kappaB binding		 cytosol,
I-kappaB/NF-kappaB complex,
nucleus		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
cytoplasmic sequestering of NF-kappaB,
negative regulation of NF-kappaB transcription factor activity,
apoptosis,
anti-apoptosis,
negative regulation of lipid storage,
negative regulation of macrophage derived foam cell differentiation,
positive regulation of cholesterol efflux,
interspecies interaction between organisms,
positive regulation of cellular protein metabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 32 KERLLDDRHDSGLDSMKDEEY IKK_group 10723127
LTP
1.00
 - -
0.63
 --
S 32 KERLLDDRHDSGLDSMKDEEY IKK_group 10882136
LTP
1.00
 - -
0.63
 --
S 36 LDDRHDSGLDSMKDEEYEQMV IKK_group 10882136
LTP
1.00
 - -
0.65
 --
S 36 LDDRHDSGLDSMKDEEYEQMV IKK_group 9346484
LTP
1.00
 - -
0.65
 --

Substrate: IKK-beta (Inhibitor of nuclear factor kappa B kinase beta subunit)
Seq-ID: O14920 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-47842   IKBA_HUMAN
MINT-47854   IKBB_HUMAN
MINT-47955   IKKA_HUMAN
MINT-48066   HS71L_HUMAN
MINT-48067   GRP78_HUMAN
MINT-48068   HSP7C_HUMAN
MINT-48070   GRP75_HUMAN
MINT-48071   IQGA1_HUMAN
MINT-48072   CDC37_HUMAN
MINT-48073   SYEP_HUMAN
MINT-48074   C1QBP_HUMAN
MINT-48075   SMRC1_HUMAN
MINT-48077   MYH10_HUMAN
MINT-48078   ACTG_HUMAN
MINT-48080   CLH1_HUMAN
MINT-48084   CALM_HUMAN
MINT-48085   TBB5_HUMAN
MINT-48086   TBB4_HUMAN
MINT-48087   K1967_HUMAN
MINT-48088   FLNA_HUMAN
MINT-48089   HNRPU_HUMAN
MINT-48090   PARP1_HUMAN
MINT-48091   HS90A_HUMAN
MINT-48093   HS90B_HUMAN
MINT-48174   NEMO_HUMAN
MINT-48434   M3K3_HUMAN
MINT-48728   NFKB2_HUMAN
MINT-48828   M3K14_HUMAN
MINT-50167   TF65_HUMAN
MINT-4652778   M3K7_HUMAN
MINT-4787797   MARK3_HUMAN
MINT-7295816   P53_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
identical protein binding,
transcription activator activity,
IkappaB kinase activity,
ATP binding		 membrane raft anti-apoptosis,
positive regulation of NF-kappaB transcription factor activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 177 LGYAKELDQGSLCTSFVGTLQ IKK_group 10779355
LTP
0.94
 - STYKc
0.08
 --
S 181 KELDQGSLCTSFVGTLQYLAP IKK_group 10195894
LTP
0.96
 - STYKc
0.08
 --
S 670 IACSKVRGPVSGSPDSMNASR IKK_group 10195894
LTP
0.19
 - -
0.55
 --
S 672 CSKVRGPVSGSPDSMNASRLS IKK_group 10195894
LTP
1.00
 - -
0.63
 --
S 675 VRGPVSGSPDSMNASRLSQPG IKK_group 10195894
LTP
0.30
 - -
0.70
 --
S 682 SPDSMNASRLSQPGQLMSQPS IKK_group 10195894
LTP
0.19
 - -
0.73
 --
S 689 SRLSQPGQLMSQPSTASNSLP IKK_group 10195894
LTP
0.20
 - -
0.70
 --
S 692 SQPGQLMSQPSTASNSLPEPA IKK_group 10195894
LTP
0.79
 - -
0.75
 --
S 695 GQLMSQPSTASNSLPEPAKKS IKK_group 10195894
LTP
0.17
 - -
0.75
 --
S 697 LMSQPSTASNSLPEPAKKSEE IKK_group 10195894
LTP
0.31
 - -
0.74
 --
S 705 SNSLPEPAKKSEELVAEAHNL IKK_group 10195894
LTP
0.12
 - -
0.56
 3BRV 95.08%
S 733 IQDTVREQDQSFTALDWSWLQ IKK_group 10195894
LTP
1.00
 - -
0.41
 3BRV 40.98%
S 740 QDQSFTALDWSWLQTEEEEHS IKK_group 10195894
LTP
1.00
 - -
0.44
 3BRV 59.84%
S 750 SWLQTEEEEHSCLEQAS     IKK_group 10195894
LTP
0.19
 - -
0.52
 --

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35568 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19010   INSR_HUMAN
MINT-68735   P85A_HUMAN
MINT-74551   EGFR_HUMAN
MINT-74553   ERBB2_HUMAN
MINT-3975430   1433S_HUMAN
MINT-6628637   LT_SV40
MINT-6793745   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
protein kinase C binding,
insulin-like growth factor receptor binding,
insulin receptor binding,
transmembrane receptor protein tyrosine kinase docking protein activity,
SH2 domain binding		 microsome,
caveola,
cytosol,
insulin receptor complex,
nucleus		 negative regulation of insulin receptor signaling pathway,
glucose homeostasis,
positive regulation of insulin receptor signaling pathway,
positive regulation of fatty acid beta-oxidation,
phosphoinositide 3-kinase cascade,
negative regulation of insulin secretion,
positive regulation of glycogen biosynthetic process,
insulin receptor signaling pathway,
positive regulation of glucose import,
positive regulation of phosphoinositide 3-kinase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 268 RAMSDEFRPRSKSQSSSNCSN IKK_group 12351658
LTP
1.00
 - -
0.69
 --
S 270 MSDEFRPRSKSQSSSNCSNPI IKK_group 12351658
LTP
1.00
 YWHAG 14-3-3;
YWHAZ 14-3-3		 -
0.69
 --
S 272 DEFRPRSKSQSSSNCSNPISV IKK_group 12351658
LTP
1.00
 - -
0.67
 --
S 274 FRPRSKSQSSSNCSNPISVPL IKK_group 12351658
LTP
1.00
 - -
0.69
 --
S 307 VGLTRRSRTESITATSPASMV IKK_group 12351658
LTP
1.00
 - -
0.78
 --
S 312 RSRTESITATSPASMVGGKPG IKK_group 12351658
LTP
1.00
 - -
0.80
 --
S 341 DGEGTMSRPASVDGSPVSPST IKK_group 12351658
LTP
0.96
 - -
0.90
 --
S 345 TMSRPASVDGSPVSPSTNRTH IKK_group 12351658
LTP
1.00
 - -
0.90
 --
S 527 LDNRFRKRTHSAGTSPTITHQ IKK_group 12351658
LTP
1.00
 - -
0.82
 --
S 531 FRKRTHSAGTSPTITHQKTPS IKK_group 12351658
LTP
1.00
 - -
0.89
 --

Substrate: Insulin receptor substrate 2 (Adaptor molecule)
Seq-ID: Q9Y4H2 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-18053   IGF1R_HUMAN
MINT-18199   INSR_HUMAN
MINT-50999   1433B_HUMAN
MINT-3295882   1433Z_HUMAN
MINT-3975441   1433S_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
signal transducer activity plasma membrane,
cytosol		 negative regulation of kinase activity,
positive regulation of insulin secretion,
positive regulation of B cell proliferation,
positive regulation of fatty acid beta-oxidation,
response to glucose stimulus,
lipid homeostasis,
positive regulation of glycogen biosynthetic process,
negative regulation of plasma membrane long-chain fatty acid transport,
negative regulation of B cell apoptosis,
insulin receptor signaling pathway,
positive regulation of glucose import,
glucose metabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 304 LKELFEFRPRSKSQSSGSSAT IKK_group 12351658
LTP
1.00
 - -
0.53
 - medium
S 306 ELFEFRPRSKSQSSGSSATHP IKK_group 12351658
LTP
1.00
 - -
0.58
 - medium
S 384 GAAAAGARPVSVAGSPLSPGP IKK_group 12351658
LTP
1.00
 - -
0.74
 - medium
S 388 AGARPVSVAGSPLSPGPVRAP IKK_group 12351658
LTP
1.00
 - -
0.78
 - medium
S 577 LDRGLRKRTYSLTTPARQRPV IKK_group 12351658
LTP
1.00
 - -
0.77
 - medium

Substrate: NF-kappa-B essential modulator (Serine/threonine kinase)
Seq-ID: O88522 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
MINT-7262667   UBIQ_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
metal ion binding nucleus transcription,
activation of NF-kappaB-inducing kinase activity,
B cell homeostasis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 369 PPLLPAPAHHSFHLALSNQRR IKK_group 11971901
LTP
1.00
 - -
0.61
 - medium

Substrate: Nuclear factor NF-kappa-B p105 subunit (Nuclear factor NF-kappa-B p105 subunit)
Seq-ID: P19838 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-47827   M3K8_HUMAN
MINT-47861   IKBB_HUMAN
MINT-48545   TPR_HUMAN
MINT-48546   KCRB_HUMAN
MINT-48547   CLH1_HUMAN
MINT-48555   VIME_HUMAN
MINT-48556   ADT3_HUMAN
MINT-48557   DESP_HUMAN
MINT-48560   JIP4_HUMAN
MINT-48561   COPB2_HUMAN
MINT-48636   BAG2_HUMAN
MINT-48638   NEMO_HUMAN
MINT-48639   HS71L_HUMAN
MINT-48640   GRP78_HUMAN
MINT-48641   HSP7C_HUMAN
MINT-48642   HNRPF_HUMAN
MINT-48643   IKKA_HUMAN
MINT-48644   ADT2_HUMAN
MINT-48645   GRP75_HUMAN
MINT-48646   RUVB2_HUMAN
MINT-48648   IMA3_HUMAN
MINT-48650   DNJA1_HUMAN
MINT-48651   IMA4_HUMAN
MINT-48653   C1QBP_HUMAN
MINT-48654   EF1A2_HUMAN
MINT-48655   MATR3_HUMAN
MINT-48656   IKBA_HUMAN
MINT-48659   MYH10_HUMAN
MINT-48660   PYR1_HUMAN
MINT-48663   ACTG_HUMAN
MINT-48665   STUB1_HUMAN
MINT-48666   REL_HUMAN
MINT-48669   TBB6_HUMAN
MINT-48670   CALM_HUMAN
MINT-48671   NONO_HUMAN
MINT-48672   TBB5_HUMAN
MINT-48673   TBB4_HUMAN
MINT-48675   K1967_HUMAN
MINT-48677   DNJA3_HUMAN
MINT-48678   MYH9_HUMAN
MINT-48679   RS8_HUMAN
MINT-48680   SFPQ_HUMAN
MINT-48682   HS90A_HUMAN
MINT-48684   PRKDC_HUMAN
MINT-48685   MYL6_HUMAN
MINT-48687   HNRPM_HUMAN
MINT-48688   HS90B_HUMAN
MINT-48689   ML12A_HUMAN
MINT-48724   NFKB2_HUMAN
MINT-48996   RELB_HUMAN
MINT-50169   HDAC1_HUMAN
MINT-7023862   CTNB1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
promoter binding,
sequence-specific DNA binding transcription factor activity,
protein binding		 cytosol,
I-kappaB/NF-kappaB complex,
nucleoplasm		 negative regulation of gene-specific transcription from RNA polymerase II promoter,
transcription from RNA polymerase II promoter,
positive regulation of transcription,
negative regulation of cellular protein metabolic process,
apoptosis,
anti-apoptosis,
negative regulation of cholesterol transport,
membrane protein intracellular domain proteolysis,
positive regulation of lipid storage,
signal transduction,
inflammatory response,
positive regulation of macrophage derived foam cell differentiation,
negative regulation of vitamin D biosynthetic process,
negative regulation of calcidiol 1-monooxygenase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 923 QQIDELRDSDSVCDSGVETSF IKK_group 11158290
LTP
0.09
 - -
0.49
 --
S 927 ELRDSDSVCDSGVETSFRKLS IKK_group 11158290
LTP
1.00
 - -
0.41
 --
S 927 ELRDSDSVCDSGVETSFRKLS IKK_group 12482991
LTP
1.00
 - -
0.41
 --

Substrate: p65 (Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit), RelA)
Seq-ID: Q04206 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-50016   IKBA_MOUSE
MINT-50017   IKBB_MOUSE
MINT-50025   KAPCA_HUMAN
MINT-50073   KS6A5_HUMAN
MINT-50084   KPCZ_HUMAN
MINT-50090   CSK21_HUMAN
MINT-50107   IKKA_HUMAN
MINT-50167   IKKB_HUMAN
MINT-50171   HDAC1_HUMAN
MINT-50175   KAT2B_HUMAN
MINT-50178   EP300_HUMAN
MINT-50179   HDAC3_HUMAN
MINT-58638   NCF1_HUMAN
MINT-62399   TF2B_HUMAN
MINT-2834593   NCOA3_HUMAN
MINT-6166971   OGT1_HUMAN
MINT-7235700   ASPP2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription repressor activity,
transcription repressor binding,
identical protein binding,
protein kinase binding,
ubiquitin protein ligase binding,
transcription activator binding,
transcription activator activity,
RNA polymerase II transcription factor activity, enhancer binding,
promoter binding,
protein N-terminus binding,
phosphate binding,
NF-kappaB binding		 cytosol,
transcription factor complex		 transcription,
positive regulation of I-kappaB kinase/NF-kappaB cascade,
cytokine-mediated signaling pathway,
anti-apoptosis,
defense response to virus,
membrane protein intracellular domain proteolysis,
cellular defense response,
inflammatory response,
nucleotide-binding oligomerization domain containing 2 signaling pathway,
response to interleukin-1,
interspecies interaction between organisms,
positive regulation of NF-kappaB transcription factor activity,
positive regulation of transcription from RNA polymerase II promoter,
response to UV-B,
negative regulation of gene-specific transcription
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 536 GLLSGDEDFSSIADMDFSALL IKK_group 10521409
LTP
0.93
 - -
0.35
 --

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