List of substrates found:


Substrate: CCR2 (Monocyte chemoattractant protein 1 receptor)
Seq-ID: P41597 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
CCR2 chemokine receptor binding,
C-C chemokine receptor activity		 cytoplasm,
integral to plasma membrane,
soluble fraction		 cytokine-mediated signaling pathway,
JAK-STAT cascade,
cellular defense response,
immune response,
inflammatory response,
chemotaxis,
interspecies interaction between organisms,
elevation of cytosolic calcium ion concentration,
negative regulation of adenylate cyclase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 139 FFIILLTIDRYLAIVHAVFAL JAK2 9670957
LTP
1.00
 - 7tm_1
0.00
 - low

Substrate: CTLA-4 (CD152 antigen)
Seq-ID: P09793 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
external side of plasma membrane,
integral to membrane		 immune response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 201 KKRSPLTTGVYVKMPPTEPEC JAK2 10842319
LTP
1.00
 - -
0.36
 - low

Substrate: CTLA-4 (CD152 antigen)
Seq-ID: P16410 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
external side of plasma membrane,
integral to plasma membrane,
Golgi apparatus,
perinuclear region of cytoplasm,
clathrin-coated endocytic vesicle		 negative regulation of regulatory T cell differentiation,
immune response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 201 KKRSPLTTGVYVKMPPTEPEC JAK2 10842319
LTP
1.00
 PIK3R1 SH2;
PTPN11 SH2		 -
0.37
 - low

Substrate: Epo-R (Receptor for erythropoietin, a major activator of erythropoiesis)
Seq-ID: P19235 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-73504   PTN6_HUMAN
MINT-74896   PTN6_MOUSE
MINT-6794748   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
erythropoietin receptor activity extracellular region,
integral to plasma membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 368 PVGSEHAQDTYLVLDKWLLPR JAK2 10579919
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
STAT5 SH2;
SYK SH2		 -
0.32
 - low

Substrate: GH-R (Growth hormon receptor)
Seq-ID: P10912 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-6797534   DUS7_HUMAN
MINT-6797749   PTN2_HUMAN
MINT-6797775   PTN9_HUMAN
MINT-6797788   PTPRB_HUMAN
MINT-6797829   PTN1_HUMAN
MINT-6797890   PTN3_HUMAN
MINT-7250542   NCK1_HUMAN
MINT-7252318   P85A_HUMAN
MINT-7252594   PLCG1_HUMAN
MINT-7254526   CRK_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein homodimerization activity,
protein kinase binding,
peptide hormone binding,
growth factor binding,
proline-rich region binding		 growth hormone receptor complex,
integral to plasma membrane,
cell surface,
extracellular space		 valine metabolic process,
activation of JAK2 kinase activity,
oxaloacetate metabolic process,
creatinine metabolic process,
isoleucine metabolic process,
positive regulation of tyrosine phosphorylation of Stat3 protein,
taurine metabolic process,
positive regulation of tyrosine phosphorylation of Stat5 protein,
response to estradiol stimulus,
insulin-like growth factor receptor signaling pathway,
allantoin metabolic process,
fatty acid metabolic process,
positive regulation of multicellular organism growth,
response to cycloheximide,
citrate metabolic process,
activation of MAPK activity,
multicellular organismal metabolic process,
2-oxoglutarate metabolic process,
succinate metabolic process,
growth hormone receptor signaling pathway,
endocytosis,
creatine metabolic process,
receptor internalization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 332 VNTILAIHDSYKPEFHSDDSW JAK2 9121492
LTP
0.90
 - -
0.23
 - low
Y 487 NPSSLSNIDFYAQVSDITPAG JAK2 9121492
LTP
1.00
 CISH SH2;
GRB10 SH2;
SOCS2 SH2;
STAT3 SH2;
STAT5 SH2		 -
0.42
 - low

Substrate: JAK2 (Cytoplasmic tyrosine kinase)
Seq-ID: O60674 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13705   BRCA1_HUMAN
MINT-61281   G3BP1_HUMAN
MINT-74562   EGFR_HUMAN
MINT-74563   ERBB3_HUMAN
MINT-6764602   PTN1_HUMAN
MINT-7250518   NCK1_HUMAN
MINT-7251766   P85A_HUMAN
MINT-7252666   PLCG1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
histone binding,
Janus kinase activity,
histone kinase activity (H3-Y41 specific),
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
growth hormone receptor binding,
SH2 domain binding		 cytoskeleton,
endomembrane system		 activation of JAK2 kinase activity,
cytokine-mediated signaling pathway,
cellular component movement,
mesoderm development,
positive regulation of tyrosine phosphorylation of Stat3 protein,
positive regulation of tyrosine phosphorylation of Stat5 protein,
erythrocyte differentiation,
protein amino acid autophosphorylation,
JAK-STAT cascade involved in growth hormone signaling pathway,
response to antibiotic
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1007 LTKVLPQDKEYYKVKEPGESP JAK2 9111318
LTP
1.00
 SOCS1 SH2;
SOCS3 SH2		 TyrKc
0.27
 3E62 61.14%
Y 1008 TKVLPQDKEYYKVKEPGESPI JAK2 11818507
LTP
1.00
 - TyrKc
0.25
 3E62 40.17%

Substrate: JAK2 (Cytoplasmic tyrosine kinase)
Seq-ID: Q62120 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-17285   PTPRC_MOUSE
MINT-2738306   SHC1_HUMAN
MINT-3378545   EPOR_MOUSE
MINT-4507367   KPCA_HUMAN
MINT-6795050   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
histone binding,
Janus kinase activity,
interleukin-12 receptor binding,
histone kinase activity (H3-Y41 specific),
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 caveola,
cytoskeleton,
endomembrane system		 activation of JAK2 kinase activity,
positive regulation of phosphoinositide 3-kinase cascade,
STAT protein nuclear translocation,
cytokine-mediated signaling pathway,
negative regulation of cell proliferation,
apoptosis,
positive regulation of tyrosine phosphorylation of Stat3 protein,
positive regulation of growth hormone receptor signaling pathway,
positive regulation of tyrosine phosphorylation of Stat5 protein,
erythrocyte differentiation,
negative regulation of DNA binding,
protein amino acid autophosphorylation,
JAK-STAT cascade involved in growth hormone signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 221 PKCVRAKIQDYHILTRKRIRY JAK2 15143187
LTP
0.57
 - B41
0.08
 - medium
Y 221 PKCVRAKIQDYHILTRKRIRY JAK2 15143188
LTP
0.57
 - B41
0.08
 - medium
Y 570 FKGVRREVGDYGQLHKTEVLL JAK2 15143187
LTP
0.20
 - STYKc
0.16
 - medium
Y 570 FKGVRREVGDYGQLHKTEVLL JAK2 16705159
LTP
0.20
 - STYKc
0.16
 - medium
Y 570 FKGVRREVGDYGQLHKTEVLL JAK2 15143188
LTP
0.20
 - STYKc
0.16
 - medium
Y 813 RDLNSLFTPDYELLTENDMLP JAK2 15121872
LTP
0.95
 - -
0.28
 - medium
Y 1007 LTKVLPQDKEYYKVKEPGESP JAK2 9111318
LTP
1.00
 - TyrKc
0.27
 - medium
Y 1007 LTKVLPQDKEYYKVKEPGESP JAK2 15143187
LTP
1.00
 - TyrKc
0.27
 - medium
Y 1007 LTKVLPQDKEYYKVKEPGESP JAK2 15530433
LTP
1.00
 - TyrKc
0.27
 - medium
Y 1008 TKVLPQDKEYYKVKEPGESPI JAK2 9111318
LTP
1.00
 - TyrKc
0.25
 - medium
Y 1008 TKVLPQDKEYYKVKEPGESPI JAK2 15530433
LTP
1.00
 - TyrKc
0.25
 - medium

Substrate: SH2-B beta signaling protein (Unclassified)
Seq-ID: ENSP00000352232 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
MINT-74717   EGFR_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
signal transducer activity cytoplasm,
nucleus,
membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 439 ESNDRLSQGAYGGLSDRPSAS JAK2 12551917
LTP
0.10
 - -
0.71
 - medium
Y 494 TGTVHPLSAPYPPLDTPETAT JAK2 12551917
LTP
0.14
 - -
0.76
 - medium

Substrate: STAT 1 (Transcription factor)
Seq-ID: P42224 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-74755   ERBB2_HUMAN
MINT-7264037   CBP_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium ion binding,
hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity,
sequence-specific DNA binding transcription factor activity,
protein binding		 cytoplasm,
nucleolus		 transcription from RNA polymerase II promoter,
activation of caspase activity,
I-kappaB kinase/NF-kappaB cascade,
interspecies interaction between organisms,
regulation of transcription, DNA-dependent,
response to virus,
tyrosine phosphorylation of STAT protein
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 701 MELDGPKGTGYIKTELISVSE JAK2 11438544
LTP
1.00
 STAT1 SH2;
STAT2 SH2		 -
0.47
 1BF5 139.74%
Y 701 MELDGPKGTGYIKTELISVSE JAK2 14978237
LTP
1.00
 STAT1 SH2;
STAT2 SH2		 -
0.47
 1BF5 139.74%

Substrate: STAT 3 (Transcription factor)
Seq-ID: P40763 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-74756   ERBB2_HUMAN
MINT-6764613   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein dimerization activity,
calcium ion binding,
hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity,
protein kinase binding,
transcription activator activity,
transcription factor binding,
sequence-specific DNA binding transcription factor activity		 plasma membrane,
cytoplasm,
nucleus		 interleukin-6-mediated signaling pathway,
eating behavior,
glucose homeostasis,
cellular component movement,
response to estradiol stimulus,
temperature homeostasis,
interspecies interaction between organisms,
JAK-STAT cascade involved in growth hormone signaling pathway,
sexual reproduction,
eye photoreceptor cell differentiation,
negative regulation of transcription from RNA polymerase II promoter
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 705 PEADPGSAAPYLKTKFICVTP JAK2 9582023
LTP
0.63
 STAT3 SH2 -
0.34
 1BG1 138.86%

Substrate: STAT 5 (Transcription factor)
Seq-ID: P42229 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-50646   ESR1_HUMAN
MINT-58264   STAP2_HUMAN
MINT-6793989   PTN1_HUMAN
MINT-7891339   EPOR_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium ion binding,
sequence-specific DNA binding transcription factor activity,
protein binding		 cytoplasm,
nucleus		 valine metabolic process,
oxaloacetate metabolic process,
transcription,
creatinine metabolic process,
isoleucine metabolic process,
JAK-STAT cascade,
taurine metabolic process,
allantoin metabolic process,
fatty acid metabolic process,
citrate metabolic process,
2-oxoglutarate metabolic process,
succinate metabolic process,
creatine metabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 694 TPVLAKAVDGYVKPQIKQVVP JAK2 11641791
LTP
0.25
 CRKL SH2;
PTPN11 SH2;
STAT5 SH2		 SH2
0.20
 - medium

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