List of substrates found:


Substrate: CCR2 (Monocyte chemoattractant protein 1 receptor)
Seq-ID: P41597 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 139 FFIILLTIDRYLAIVHAVFAL JAK2 9670957
LTP
1.00
- 7tm_1
0.00
- low

Substrate: CTLA-4 (CD152 antigen)
Seq-ID: P09793 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
external side of plasma membrane,
integral to membrane
immune response
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 201 KKRSPLTTGVYVKMPPTEPEC JAK2 10842319
LTP
1.00
- -
0.36
- low

Substrate: CTLA-4 (CD152 antigen)
Seq-ID: P16410 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 201 KKRSPLTTGVYVKMPPTEPEC JAK2 10842319
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.37
- low

Substrate: Epo-R (Receptor for erythropoietin, a major activator of erythropoiesis)
Seq-ID: P19235 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
erythropoietin receptor activity extracellular region,
integral to plasma membrane
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 368 PVGSEHAQDTYLVLDKWLLPR JAK2 10579919
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
STAT5 SH2;
SYK SH2
-
0.32
- low

Substrate: GH-R (Growth hormon receptor)
Seq-ID: P10912 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 332 VNTILAIHDSYKPEFHSDDSW JAK2 9121492
LTP
0.90
- -
0.23
- low
Y 487 NPSSLSNIDFYAQVSDITPAG JAK2 9121492
LTP
1.00
CISH SH2;
GRB10 SH2;
SOCS2 SH2;
STAT3 SH2;
STAT5 SH2
-
0.42
- low

Substrate: JAK2 (Cytoplasmic tyrosine kinase)
Seq-ID: O60674 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1007 LTKVLPQDKEYYKVKEPGESP JAK2 9111318
LTP
1.00
SOCS1 SH2;
SOCS3 SH2
TyrKc
0.27
3E62 61.14%
Y 1008 TKVLPQDKEYYKVKEPGESPI JAK2 11818507
LTP
1.00
- TyrKc
0.25
3E62 40.17%

Substrate: JAK2 (Cytoplasmic tyrosine kinase)
Seq-ID: Q62120 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 221 PKCVRAKIQDYHILTRKRIRY JAK2 15143187
LTP
0.57
- B41
0.08
- medium
Y 221 PKCVRAKIQDYHILTRKRIRY JAK2 15143188
LTP
0.57
- B41
0.08
- medium
Y 570 FKGVRREVGDYGQLHKTEVLL JAK2 15143187
LTP
0.20
- STYKc
0.16
- medium
Y 570 FKGVRREVGDYGQLHKTEVLL JAK2 16705159
LTP
0.20
- STYKc
0.16
- medium
Y 570 FKGVRREVGDYGQLHKTEVLL JAK2 15143188
LTP
0.20
- STYKc
0.16
- medium
Y 813 RDLNSLFTPDYELLTENDMLP JAK2 15121872
LTP
0.95
- -
0.28
- medium
Y 1007 LTKVLPQDKEYYKVKEPGESP JAK2 9111318
LTP
1.00
- TyrKc
0.27
- medium
Y 1007 LTKVLPQDKEYYKVKEPGESP JAK2 15143187
LTP
1.00
- TyrKc
0.27
- medium
Y 1007 LTKVLPQDKEYYKVKEPGESP JAK2 15530433
LTP
1.00
- TyrKc
0.27
- medium
Y 1008 TKVLPQDKEYYKVKEPGESPI JAK2 9111318
LTP
1.00
- TyrKc
0.25
- medium
Y 1008 TKVLPQDKEYYKVKEPGESPI JAK2 15530433
LTP
1.00
- TyrKc
0.25
- medium

Substrate: SH2-B beta signaling protein (Unclassified)
Seq-ID: ENSP00000352232 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
signal transducer activity cytoplasm,
nucleus,
membrane
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 439 ESNDRLSQGAYGGLSDRPSAS JAK2 12551917
LTP
0.10
- -
0.71
- medium
Y 494 TGTVHPLSAPYPPLDTPETAT JAK2 12551917
LTP
0.14
- -
0.76
- medium

Substrate: STAT 1 (Transcription factor)
Seq-ID: P42224 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 701 MELDGPKGTGYIKTELISVSE JAK2 11438544
LTP
1.00
STAT1 SH2;
STAT2 SH2
-
0.47
1BF5 139.74%
Y 701 MELDGPKGTGYIKTELISVSE JAK2 14978237
LTP
1.00
STAT1 SH2;
STAT2 SH2
-
0.47
1BF5 139.74%

Substrate: STAT 3 (Transcription factor)
Seq-ID: P40763 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 705 PEADPGSAAPYLKTKFICVTP JAK2 9582023
LTP
0.63
STAT3 SH2 -
0.34
1BG1 138.86%

Substrate: STAT 5 (Transcription factor)
Seq-ID: P42229 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 694 TPVLAKAVDGYVKPQIKQVVP JAK2 11641791
LTP
0.25
CRKL SH2;
PTPN11 SH2;
STAT5 SH2
SH2
0.20
- medium

Valid HTML 4.01 Transitional