Click on substrate name for additional information.


Substrate: VEGFR-2 (Receptor tyrosine kinase)
Seq-ID: P35918 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
vascular endothelial growth factor receptor activity,
ATP binding,
growth factor binding		 integral to plasma membrane branching morphogenesis of a tube,
positive regulation of mesenchymal cell proliferation,
protein amino acid phosphorylation,
angiogenesis,
cell migration,
hemopoiesis,
cell fate commitment,
cell maturation,
endothelial cell differentiation,
surfactant homeostasis,
positive regulation of epithelial cell proliferation,
vasculogenesis,
lung alveolus development,
calcium ion homeostasis,
ovarian follicle development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1212 EEEVCDPKFHYDNTAGISHYL KDR 12023952
LTP
0.23
 Src SH2 -
0.45
 - medium
Y 1212 EEEVCDPKFHYDNTAGISHYL KDR 15107818
LTP
0.23
 Src SH2 -
0.45
 - medium

Substrate: VEGFR-2 (Receptor tyrosine kinase)
Seq-ID: P35968 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-49634   CADH5_HUMAN
MINT-49637   SHC1_HUMAN
MINT-2834292   NRP1_HUMAN
MINT-3381238   GRB2_HUMAN
MINT-3381278   NCK1_HUMAN
MINT-3381335   FYN_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Hsp90 protein binding,
vascular endothelial growth factor receptor activity,
receptor signaling protein tyrosine kinase activity,
ATP binding,
growth factor binding,
integrin binding		 integral to plasma membrane positive regulation of positive chemotaxis,
protein amino acid phosphorylation,
positive regulation of endothelial cell proliferation,
angiogenesis,
regulation of cell shape,
interspecies interaction between organisms,
positive regulation of endothelial cell migration,
positive regulation of focal adhesion assembly
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 951 KGARFRQGKDYVGAIPVDLKR KDR 10579917
LTP
0.03
 - TyrKc
0.21
 2OH4 25.23%
Y 996 VEEEEAPEDLYKDFLTLEHLI KDR 10579917
LTP
0.30
 - TyrKc
0.13
 2P2H 26.20%
Y 1054 ICDFGLARDIYKDPDYVRKGD KDR 10579917
LTP
1.00
 - TyrKc
0.13
 1YWN 75.55%
Y 1175 QANAQQDGKDYIVLPISETLS KDR 10579917
LTP
1.00
 PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2		 -
0.41
 --
Y 1175 QANAQQDGKDYIVLPISETLS KDR 11387210
LTP
1.00
 PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2		 -
0.41
 --
Y 1214 EEEVCDPKFHYDNTAGISQYL KDR 12023952
LTP
0.24
 Src SH2 -
0.46
 --
Y 1214 EEEVCDPKFHYDNTAGISQYL KDR 11387210
LTP
0.24
 Src SH2 -
0.46
 --

Substrate: VEGFR3 long form (Vascular endothelial growth factor receptor)
Seq-ID: ENSP00000261937 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ATP binding integral to plasma membrane protein amino acid phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1230 SLQRHSLAARYYNWVSFPGCL KDR 12881528
LTP
0.15
 - -
0.24
 - medium
Y 1231 LQRHSLAARYYNWVSFPGCLA KDR 12881528
LTP
0.97
 - -
0.21
 - medium
Y 1265 FEEFPMTPTTYKGSVDNQTDS KDR 12881528
LTP
0.09
 - -
0.70
 - medium

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