Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

AMPK alpha 1
BRSK1
BRSK2
EMK1
KIAA0999
Mark1
MARK3
MARK4
MELK
NUAK1
NUAK2
PTEN
Serine/threonine-protein kinase 11
SNF1LK
SNF1LK2
SNRK

Substrate:

AMPK alpha 1 (Serine/threonine kinase)

Seq-ID:

Q13131 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-6771238 AAKB1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cAMP-dependent protein kinase activity, metal ion binding, ATP binding, protein binding	cytosol	response to hypoxia, fatty acid biosynthetic process, positive regulation of anti-apoptosis, negative regulation of glucosylceramide biosynthetic process, activation of MAPK activity, cholesterol biosynthetic process, regulation of fatty acid oxidation, positive regulation of cholesterol biosynthetic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	174	NMMSDGEFLRTSCGSPNYAAP	LKB1	14614828	LTP	-	S_TKc	0.26	-	medium
T	174	NMMSDGEFLRTSCGSPNYAAP	LKB1	14511394	LTP	-	S_TKc	0.26	-	medium
T	174	NMMSDGEFLRTSCGSPNYAAP	LKB1	14985505	LTP	-	S_TKc	0.26	-	medium

Substrate:

BRSK1 (ATP binding, protein serine/threonine kinase activity)

Seq-ID:

Q8TDC3 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-19873 SHC1_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding	cell junction, cytoplasm, nucleus	protein amino acid phosphorylation, response to UV, establishment of cell polarity, G2/M transition DNA damage checkpoint, neuron differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	205	SLQVGDSLLETSCGSPHYACP	LKB1	14976552	LTP	1.00		-	S_TKc	0.17	-	low

Substrate:

BRSK2 (ser/thr kinase)

Seq-ID:

Q8IWQ3 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding		protein amino acid phosphorylation, establishment of cell polarity, neuron differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	174	SLQVGDSLLETSCGSPHYACP	LKB1	14976552	LTP	1.00		-	S_TKc	0.16	-	medium

Substrate:

EMK1 (Serine/threonine kinase)

Seq-ID:

Q7KZI7 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-48484   M3K3_HUMAN
MINT-51527   1433B_HUMAN
MINT-3294883   1433Z_HUMAN
MINT-3975077   1433S_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding, protein binding	plasma membrane	protein amino acid phosphorylation, response to oxidative stress, establishment or maintenance of epithelial cell apical/basal polarity, cell differentiation, multicellular organismal development, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	208	NEFTFGNKLDTFCGSPPYAAP	LKB1	14976552	LTP	1.00		-	S_TKc	0.16	1ZMW	67.26%

Substrate:

KIAA0999 (ser/thr kinase)

Seq-ID:

Q9Y2K2 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding, protein binding	cytoplasm	protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	163	NLFTPGQLLKTWCGSPPYAAP	LKB1	14976552	LTP	1.00		-	S_TKc	0.10	-	low

Substrate:

Mark1 (Serine/threonine-protein kinase)

Seq-ID:

Q9P0L2 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-3975066 1433S_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding	cytoplasm, microtubule cytoskeleton	protein amino acid phosphorylation, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	215	NEFTVGNKLDTFCGSPPYAAP	LKB1	14976552	LTP	1.00		-	S_TKc	0.20	-	-

Substrate:

MARK3 (protein binding)

Seq-ID:

P27448 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16617   PKP2_HUMAN
MINT-50984   1433B_HUMAN
MINT-63618   CPSF4_HUMAN
MINT-63620   SCG1_HUMAN
MINT-63622   PLPL2_HUMAN
MINT-63625   SAAL1_HUMAN
MINT-3295530   1433Z_HUMAN
MINT-3975719   1433S_HUMAN
MINT-4787797   IKKB_HUMAN
MINT-4787821   KPCT_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding, protein binding		protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	234	NEFTVGGKLDTFCGSPPYAAP	LKB1	14976552	LTP	1.00		-	S_TKc	0.18	3FE3	30.09%

Substrate:

MARK4 (ATP binding, gamma-tubulin binding)

Seq-ID:

Q96L34 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, tau-protein kinase activity, ATP binding, microtubule binding, gamma-tubulin binding, ubiquitin binding	centrosome, neuron projection	nervous system development, protein amino acid phosphorylation, positive regulation of programmed cell death, microtubule bundle formation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	214	NEFTLGSKLDTFCGSPPYAAP	LKB1	14976552	LTP	1.00		-	S_TKc	0.16	-	low

Substrate:

MELK (ser/thr kinase)

Seq-ID:

Q14680 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding, protein binding	cytoplasm	protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	167	PKGNKDYHLQTCCGSLAYAAP	LKB1	14976552	LTP	1.00		-	S_TKc	0.11	-	medium

Substrate:

NUAK1 (ser/thr kinase)

Seq-ID:

O60285 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, metal ion binding, ATP binding, protein binding		protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	211	NLYQKDKFLQTFCGSPLYASP	LKB1	14976552	LTP	1.00		-	S_TKc	0.10	-	medium

Substrate:

NUAK2 (ATP binding, magnesium ion binding)

Seq-ID:

Q9H093 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding		protein amino acid phosphorylation, negative regulation of apoptosis, actin cytoskeleton organization, cellular response to glucose starvation, apoptosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	208	NLYHQGKFLQTFCGSPLYASP	LKB1	14976552	LTP	1.00		-	S_TKc	0.09	-	low

Substrate:

PTEN (Lipid phosphatase)

Seq-ID:

P60484 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-63918   SCG1_HUMAN
MINT-63919   HBA_HUMAN
MINT-63921   UT14A_HUMAN
MINT-2832448   NHRF1_HUMAN
MINT-2832646   NHRF2_HUMAN
MINT-2832742   NHRF2_MOUSE
MINT-2832984   PGFRB_HUMAN
MINT-6793823   CAV1_HUMAN
MINT-7266561   PRDX1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity, protein tyrosine phosphatase activity, phosphatidylinositol-3-phosphatase activity, lipid binding, protein serine/threonine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity, phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity, enzyme binding, inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity, PDZ domain binding	cytosol, nucleus	protein stabilization, inositol phosphate dephosphorylation, central nervous system development, regulation of cyclin-dependent protein kinase activity, regulation of neuron projection development, apoptosis, positive regulation of transcription factor activity, protein amino acid dephosphorylation, canonical Wnt receptor signaling pathway, phosphoinositide dephosphorylation, negative regulation of cell migration, induction of apoptosis, negative regulation of focal adhesion assembly, negative regulation of protein kinase B signaling cascade, cell proliferation, negative regulation of protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	382	NEPDHYRYSDTTDSDPENEPF	LKB1	18321849	LTP	1.00	MOD_CK2_1	-	-	0.87	-	-

Substrate:

Serine/threonine-protein kinase 11 (Serine/threonine protein kinase 11)

Seq-ID:

Q15831 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-56664 SNRK_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding	cytoplasm, nucleus	protein amino acid phosphorylation, cell cycle arrest, regulation of fatty acid oxidation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	189	PGNLLLTTGGTLKISDLGVAE	LKB1	11430832	LTP	0.94		-	S_TKc	0.16	-	medium

Substrate:

Serine/threonine-protein kinase 11 (Serine/threonine protein kinase 11)

Seq-ID:

Q9WTK7 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, LRR domain binding, ATP binding	cytoplasm, nucleus	protein amino acid phosphorylation, regulation of Wnt receptor signaling pathway, cell cycle arrest, canonical Wnt receptor signaling pathway, regulation of protein kinase B signaling cascade, negative regulation of epithelial cell proliferation involved in prostate gland development, tissue homeostasis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	336	PDTKDRWRSMTVVPYLEDLHG	LKB1	11853558	LTP	1.00		-	-	0.44	-	low
T	366	LFDIEDGIIYTQDFTVPGQVL	LKB1	11853558	LTP	0.08		-	-	0.34	-	low

Substrate:

SNF1LK (ATP binding, magnesium ion binding)

Seq-ID:

P57059 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding, protein binding	nucleus	protein amino acid phosphorylation, cell cycle, regulation of mitotic cell cycle, cell differentiation, multicellular organismal development, regulation of cell differentiation, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	182	NFYKSGEPLSTWCGSPPYAAP	LKB1	14976552	LTP	1.00		-	S_TKc	0.20	-	low

Substrate:

SNF1LK2 (ATP binding, magnesium ion binding)

Seq-ID:

Q9H0K1 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding, protein binding	Golgi apparatus	protein amino acid phosphorylation, regulation of insulin receptor signaling pathway, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	175	NFFKSGELLATWCGSPPYAAP	LKB1	14976552	LTP	1.00		-	S_TKc	0.08	-	low

Substrate:

SNRK (ATP binding, magnesium ion binding)

Seq-ID:

Q9NRH2 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-56664 STK11_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding, protein binding	nucleus	protein amino acid phosphorylation, myeloid cell differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	173	NKFQPGKKLTTSCGSLAYSAP	LKB1	15733851	LTP	1.00		-	S_TKc	0.23	-	low