List of substrates found:


Substrate: MAP2K4 (Serine/threonine kinase)
Seq-ID: P45985 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-7263269   ARRB1_HUMAN
MINT-7263286   ARRB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding,
protein tyrosine kinase activity,
protein binding		 protein amino acid phosphorylation,
JNK cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 257 DFGISGQLVDSIAKTRDAGCR MAP2K4 9162092
LTP
1.00
 - S_TKc
0.16
 - medium
T 261 SGQLVDSIAKTRDAGCRPYMA MAP2K4 9162092
LTP
1.00
 - S_TKc
0.24
 - medium

Substrate: Mitogen-activated protein kinase 10 (Mitogen activated protein kinase 10)
Seq-ID: P53779 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-63869   TF3C1_HUMAN
MINT-7148332   JUN_HUMAN
MINT-7263136   ARRB1_HUMAN
MINT-7263161   ARRB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
JUN kinase activity,
MAP kinase kinase activity,
ATP binding,
protein binding		 nucleoplasm
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 223 TAGTSFMMTPYVVTRYYRAPE MAP2K4 15911620
LTP
1.00
 - S_TKc
0.08
 2O0U 52.40%

Substrate: Mitogen-activated protein kinase 12 (Serine/threonine kinase)
Seq-ID: P53778 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-59511   SNTA1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
magnesium ion binding,
ATP binding,
MAP kinase activity,
protein binding		 mitochondrion cell cycle arrest,
myoblast differentiation,
muscle organ development,
Ras protein signal transduction,
DNA damage induced protein phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 185 ARQADSEMTGYVVTRWYRAPE MAP2K4 11062067
LTP
1.00
 - S_TKc
0.15
 1CM8 60.70%

Substrate: Mitogen-activated protein kinase 8 (Ser/thr protein kinase)
Seq-ID: P45983 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-56639   BCL2_HUMAN
MINT-56640   B2CL1_HUMAN
MINT-61312   P53_HUMAN
MINT-61313   WWOX_HUMAN
MINT-6629301   JIP1_HUMAN
MINT-7103547   CRK_HUMAN
MINT-7103623   CBL_HUMAN
MINT-7103638   P85A_HUMAN
MINT-7103692   CRKL_HUMAN
MINT-7148314   JUN_HUMAN
MINT-7288748   FLNB_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
JUN kinase activity,
ATP binding,
protein binding		 cytosol,
nucleoplasm		 response to UV,
negative regulation of apoptosis,
activation of pro-apoptotic gene products
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 185 TAGTSFMMTPYVVTRYYRAPE MAP2K4 15911620
LTP
1.00
 - S_TKc
0.07
 3ELJ 49.34%
Y 185 TAGTSFMMTPYVVTRYYRAPE MAP2K4 7839144
LTP
1.00
 - S_TKc
0.07
 3ELJ 49.34%

Substrate: Mitogen-activated protein kinase 9 (Mitogen-activated protein kinase 9)
Seq-ID: P45984 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-64910   XPO7_HUMAN
MINT-66639   K1712_HUMAN
MINT-68376   WDR62_HUMAN
MINT-7148323   JUN_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
JUN kinase activity,
ATP binding,
protein binding		 nucleoplasm positive regulation of macrophage derived foam cell differentiation,
positive regulation of gene expression
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 185 TACTNFMMTPYVVTRYYRAPE MAP2K4 11062067
LTP
1.00
 - S_TKc
0.05
 - low

Substrate: Retinoic acid receptor RXR-alpha (Retinoic acid receptor RXR-alpha)
Seq-ID: P19793 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-24895   RARA_HUMAN
MINT-61590   SMAD2_HUMAN
MINT-61758   KPCD2_HUMAN
MINT-5224970   NCOA1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
retinoid-X receptor activity,
transcription coactivator activity,
zinc ion binding,
sequence-specific DNA binding transcription factor activity,
ligand-regulated transcription factor activity,
vitamin D receptor binding,
steroid hormone receptor activity		 nucleus negative regulation of gene-specific transcription from RNA polymerase II promoter,
transcription,
vitamin metabolic process,
interspecies interaction between organisms,
response to retinoic acid,
cholesterol metabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 249 ELAVEPKTETYVEANMGLNPS MAP2K4 10938283
LTP
0.32
 - -
0.52
 1FM6 32.75%

Valid HTML 4.01 Transitional