Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Substrate:

Caspase-3 (Cysteine protease CPP32)

Seq-ID:

P42574 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13839   XIAP_HUMAN
MINT-18036   APAF_HUMAN
MINT-18815   CASP9_HUMAN
MINT-4820691   AKT1_HUMAN
MINT-4820707   AKT2_HUMAN
MINT-4820732   AKT3_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cysteine-type endopeptidase activity, protein binding	plasma membrane, mitochondrion, cytosol, nucleoplasm	negative regulation of apoptosis, proteolysis, nuclear fragmentation involved in apoptotic nuclear change, response to tumor necrosis factor

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	150	TNFFRGDRCRSLTGKPKLFII	MAPK14	14970175	LTP	0.98		-	CASc	0.11	2J32	20.49%

Substrate:

Caspase-8 precursor (Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death)

Seq-ID:

Q14790 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-64185   VIME_HUMAN
MINT-64186   CHD3_HUMAN
MINT-4051509   ANDR_HUMAN
MINT-4051954   CASP8_MOUSE
MINT-4055317   TNR6_HUMAN
MINT-4055344   FADD_HUMAN
MINT-4055393   CASPA_HUMAN
MINT-4298716   C8AP2_HUMAN
MINT-4329763   NUCL_HUMAN
MINT-4329782   TOPRS_HUMAN
MINT-4329823   MK03_HUMAN
MINT-4329848   MK01_HUMAN
MINT-6175515   NUCB1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
identical protein binding, cysteine-type endopeptidase activity	death-inducing signaling complex, cytosol, cytoskeleton, mitochondrial outer membrane	induction of apoptosis by extracellular signals, positive regulation of I-kappaB kinase/NF-kappaB cascade, proteolysis involved in cellular protein catabolic process, response to tumor necrosis factor, activation of pro-apoptotic gene products

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	347	TSQFTGLKCPSLAGKPKVFFI	MAPK14	14970175	LTP	1.00		-	CASc	0.10	1QTN	24.59%

Substrate:

Cyclic-AMP-dependent transcription factor ATF-2 (Transcription factor)

Seq-ID:

P15336 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-1788416   JUNB_HUMAN
MINT-6628041   JUN_HUMAN
MINT-6628046   CITE1_HUMAN
MINT-6699865   I2BP1_HUMAN
MINT-7555703   HDAC4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, protein dimerization activity, RNA polymerase II transcription factor activity, transcription coactivator activity, zinc ion binding, sequence-specific DNA binding transcription factor activity	nucleoplasm	transcription, regulation of transcription, DNA-dependent

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	53	DSVIVADQTPTPTRFLKNCEE	MAPK14	11971971	LTP	0.00	MOD_ProDKin_1	-	-	0.51	-	-
T	53	DSVIVADQTPTPTRFLKNCEE	MAPK14	11896587	LTP	0.00	MOD_ProDKin_1	-	-	0.51	-	-

Substrate:

Cytokeratin 8 (keratin, type II cytoskeletal 8 (cytokeratin 8) (K8) (CK8) (from PhosphoBase))

Seq-ID:

P05787 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-51056   RAF1_HUMAN
MINT-61555   GRB2_HUMAN
MINT-2984733   ZO1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
structural molecule activity, protein binding	cytoplasm, keratin filament	cytoskeleton organization, interspecies interaction between organisms

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	74	TAVTVNQSLLSPLVLEVDPNI	MAPK14	11788583	LTP	0.18	MOD_ProDKin_1	-	-	0.28	-	low

Substrate:

Estrogen receptor alpha (Estrogen receptor (ER) (Estradiol receptor) (ER-alpha); nuclear hormone receptor. )

Seq-ID:

P03372 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13786   BRCA1_HUMAN
MINT-50646   STA5A_HUMAN
MINT-50709   M3K1_HUMAN
MINT-5222241   NCOA1_HUMAN
MINT-6169667   EGFR_HUMAN
MINT-6614126   SMCA4_HUMAN
MINT-6614301   CHD3_HUMAN
MINT-6614361   MTA1_HUMAN
MINT-6614421   MTA2_HUMAN
MINT-6761899   PTN1_HUMAN
MINT-6761906   PTN6_HUMAN
MINT-7013584   PA1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
beta-catenin binding, nitric-oxide synthase regulator activity, estrogen response element binding, steroid binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, estrogen receptor activity	chromatin remodeling complex	response to estradiol stimulus, transcription, DNA-dependent, regulation of transcription, DNA-dependent, positive regulation of retinoic acid receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	311	SKKNSLALSLTADQMVSALLD	MAPK14	12138194	LTP	0.27		-	-	0.28	2IOG	52.05%

Substrate:

ETS domain protein Elk-1 (Transcription factor)

Seq-ID:

P19419 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-3380443 SUMO1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, transcription activator activity, sequence-specific DNA binding transcription factor activity, protein binding	nucleus	transcription, positive regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	383	PPSIHFWSTLSPIAPRSPAKL	MAPK14	9130707	LTP	1.00	MOD_ProDKin_1	-	-	0.43	-	medium
S	383	PPSIHFWSTLSPIAPRSPAKL	MAPK14	8887554	LTP	1.00	MOD_ProDKin_1	-	-	0.43	-	medium
S	389	WSTLSPIAPRSPAKLSFQFPS	MAPK14	9130707	LTP	0.89	MOD_ProDKin_1	-	-	0.46	-	medium

Substrate:

jdp2 (protein dimerization activity, sequence-specific DNA binding)

Seq-ID:

ENSP00000267569 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14001   ATF2_MOUSE
MINT-4788079   PRGR_HUMAN
MINT-6699850   I2BP1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding	nucleus	transcription

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	148	TCIVRTDSVKTPESEGNPLLE	MAPK14	12225289	LTP	1.00	MOD_ProDKin_1	-	-	0.63	-	low

Substrate:

MAP kinase-activated protein kinase 2 (MAP kinase-activated protein kinase 2 (EC 2.7.1.-) (from PhosphoBase))

Seq-ID:

P49137 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-2833388 LIMK1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding, signal transducer activity, protein binding	cytosol, nucleus	protein amino acid phosphorylation, MAPKKK cascade, Ras protein signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	25	PAPAPPPQPPTPALPHPPAQP	MAPK14	8846784	LTP	0.03	MOD_ProDKin_1	-	-	0.95	-	-
T	222	KETTSHNSLTTPCYTPYYVAP	MAPK14	8846784	LTP	0.95	MOD_ProDKin_1	-	S_TKc	0.26	2OZA	39.04%
S	272	PFYSNHGLAISPGMKTRIRMG	MAPK14	8846784	LTP	1.00	MOD_ProDKin_1	-	S_TKc	0.29	1KWP	51.64%
T	334	WIMQSTKVPQTPLHTSRVLKE	MAPK14	8846784	LTP	0.93	MOD_ProDKin_1	-	-	0.49	2OZA	19.86%

Substrate:

MAPKAPK5 (MAP kinase kinase activity, protein serine/threonine kinase activity)

Seq-ID:

Q8IW41 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, MAP kinase kinase activity, ATP binding, protein binding	cytoplasm, nucleus	protein amino acid phosphorylation, signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	182	FAKIDQGDLMTPQFTPYYVAP	MAPK14	9628874	LTP	0.02	MOD_ProDKin_1	-	S_TKc	0.18	-	medium

Substrate:

Myocyte-specific enhancer factor 2A (Transcription factor)

Seq-ID:

Q02078 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-49703   HDAC4_HUMAN
MINT-3380349   SUMO1_HUMAN
MINT-7973732   DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity	nucleoplasm	nervous system development, transcription, apoptosis, muscle organ development, regulation of transcription, DNA-dependent, cell differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	312	SSSQATQPLATPVVSVTTPSL	MAPK14	9858528	LTP	1.00	MOD_ProDKin_1	-	-	0.70	-	medium
T	319	PLATPVVSVTTPSLPPQGLVY	MAPK14	9858528	LTP	1.00	MOD_ProDKin_1	-	-	0.56	-	medium
S	408	QNISIKSEPISPPRDRMTPSG	MAPK14	12586839	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.88	-	medium
S	453	QPQPRQEMGRSPVDSLSSSSS	MAPK14	9858528	LTP	1.00	MOD_ProDKin_1	-	-	0.95	-	medium

Substrate:

Myocyte-specific enhancer factor 2C (Myocyte-specific enhancer factor 2C)

Seq-ID:

Q06413 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-49706 HDAC4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, protein binding	nuclear speck	negative regulation of gene-specific transcription from RNA polymerase II promoter, nervous system development, positive regulation of gene-specific transcription from RNA polymerase II promoter, transcription, apoptosis, positive regulation of survival gene product expression, muscle organ development, cell differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	293	NNSQSAQSLATPVVSVATPTL	MAPK14	9069290	LTP	1.00	MOD_ProDKin_1	-	-	0.65	-	-
T	300	SLATPVVSVATPTLPGQGMGG	MAPK14	9069290	LTP	1.00	MOD_ProDKin_1	-	-	0.63	-	-

Substrate:

Neutrophil cytosol factor 1 (Neutrophil cytosol factor 1)

Seq-ID:

P14598 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-58638   TF65_HUMAN
MINT-66383   TRIM9_HUMAN
MINT-74863   ACTB_HUMAN
MINT-3973484   KPCA_HUMAN
MINT-3973536   KPCD_HUMAN
MINT-7135171   GNAI2_HUMAN
MINT-7300360   NCF4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding, phosphoinositide binding, GTPase activity, GTP binding, electron carrier activity	cytosol, NADPH oxidase complex, soluble fraction	protein targeting to membrane, superoxide anion generation, cellular defense response, innate immune response, cell communication, respiratory burst

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	345	RRRQARPGPQSPGSPLEEERQ	MAPK14	15629715	LTP	0.37	MOD_ProDKin_1	-	p47_phox_C	0.92	-	-
S	348	QARPGPQSPGSPLEEERQTQR	MAPK14	15629715	LTP	0.81	MOD_CK2_1	-	p47_phox_C	0.94	-	-

Substrate:

NFATC4 (transcription coactivator activity)

Seq-ID:

Q14934 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7972976 DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription coactivator activity, sequence-specific DNA binding transcription factor activity	cytoplasm, nucleus	transcription from RNA polymerase II promoter, inflammatory response, regulation of transcription, DNA-dependent, cell differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	168	AGAQGGGAFFSPSPGSSSLSS	MAPK14	11997522	LTP	0.64	MOD_ProDKin_1	-	-	0.65	-	-
S	170	AQGGGAFFSPSPGSSSLSSWS	MAPK14	11997522	LTP	0.64	MOD_ProDKin_1	-	-	0.58	-	-

Substrate:

PAK6 (Serine/threonine kinase)

Seq-ID:

Q9NQU5 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding, protein binding		protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	165	HKQMPWPEPQSPRVLPNGLAA	MAPK14	15550393	LTP	0.07	MOD_ProDKin_1	-	-	0.80	-	-

Substrate:

PPARGC-1 alpha (Transcription regulatory protein)

Seq-ID:

Q9UBK2 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
RNA polymerase II transcription mediator activity, nucleotide binding, DNA binding, ligand-dependent nuclear receptor transcription coactivator activity, androgen receptor binding, ligand-dependent nuclear receptor binding, RNA binding	DNA-directed RNA polymerase II, core complex	digestion, protein stabilization, gluconeogenesis, mRNA processing, positive regulation of gluconeogenesis, positive regulation of transcription factor activity, cellular glucose homeostasis, positive regulation of gene-specific transcription, brown fat cell differentiation, temperature homeostasis, positive regulation of histone acetylation, androgen receptor signaling pathway, fatty acid oxidation, transcription initiation from RNA polymerase II promoter, RNA splicing, positive regulation of fatty acid oxidation, mitochondrion organization, response to starvation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	263	AKPTTLSLPLTPESPNDPKGS	MAPK14	11741533	LTP	1.00	MOD_ProDKin_1	-	-	0.89	-	medium
S	266	TTLSLPLTPESPNDPKGSPFE	MAPK14	11741533	LTP	1.00	MOD_ProDKin_1	-	-	0.88	-	medium
T	299	SGTAGLTPPTTPPHKANQDNP	MAPK14	11741533	LTP	1.00	MOD_ProDKin_1	-	-	0.92	-	medium

Substrate:

Ribosomal protein S6 kinase alpha 4 (Serine/threonine kinase)

Seq-ID:

O75676 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, mitogen-activated protein kinase p38 binding, ATP binding, ribosomal protein S6 kinase activity	nucleus	protein amino acid phosphorylation, regulation of transcription, DNA-dependent, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	196	FLTEEKERTFSFCGTIEYMAP	MAPK14	10806207	LTP	1.00		-	S_TKc	0.15	-	low
S	343	EEFTRLEPVYSPPGSPPPGDP	MAPK14	10806207	LTP	1.00	MOD_ProDKin_1	-	S_TK_X	0.70	-	low
S	347	RLEPVYSPPGSPPPGDPRIFQ	MAPK14	10806207	LTP	0.60	MOD_ProDKin_1	-	S_TK_X	0.66	-	low
S	360	PGDPRIFQGYSFVAPSILFDH	MAPK14	10806207	LTP	1.00		-	S_TK_X	0.27	-	low
T	568	RPQSPGVPMQTPCFTLQYAAP	MAPK14	10806207	LTP	1.00	MOD_ProDKin_1	-	S_TKc	0.36	-	low

Substrate:

RPS6KA5 (serine/threonine kinase)

Seq-ID:

O75582 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50073 TF65_HUMAN
MINT-6771456 GCR_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding, protein binding	cytoplasm, nucleoplasm	response to chemical stimulus, response to stress, epidermal growth factor receptor signaling pathway, regulation of transcription, DNA-dependent, histone phosphorylation, response to external stimulus, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	360	EEFTEMDPTYSPAALPQSSEK	MAPK14	15568999	LTP	1.00	MOD_ProDKin_1	-	S_TK_X	0.47	-	-
T	581	LKPPDNQPLKTPCFTLHYAAP	MAPK14	15568999	LTP	1.00	MOD_ProDKin_1	-	S_TKc	0.33	-	-

Substrate:

Sam68 (Adapter molecule)

Seq-ID:

Q07666 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15408   FYN_HUMAN
MINT-16809   SRC_CHICK
MINT-17535   LYN_HUMAN
MINT-56721   FNBP4_HUMAN
MINT-56723   WBP4_HUMAN
MINT-56729   ANM1_HUMAN
MINT-61611   SMAD2_HUMAN
MINT-62828   CD2B2_HUMAN
MINT-65549   STUB1_HUMAN
MINT-7051501   HCK_HUMAN
MINT-7212471   LCK_HUMAN
MINT-7300587   VAV_HUMAN
MINT-7300603   VAV_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding, transcription repressor activity, DNA binding, SH3/SH2 adaptor activity, RNA binding	nucleus, membrane	mRNA processing, transcription, cell cycle arrest, regulation of RNA export from nucleus, cell surface receptor linked signaling pathway, cell proliferation, G2/M transition of mitotic cell cycle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	58	GGGSRGGARASPATQPPPLLP	MAPK14	12478298	LTP	0.11	MOD_ProDKin_1	-	-	0.96	-	low
T	84	PDATVGGPAPTPLLPPSATAS	MAPK14	12478298	LTP	0.27	MOD_ProDKin_1	-	-	0.86	-	low

Substrate:

Sodium/hydrogen exchanger 1 (Membrane transport protein)

Seq-ID:

P19634 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	integral to membrane	regulation of pH, sodium ion transport

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	718	YEPKEDLPVITIDPASPQSPE	MAPK14	11604491	LTP	0.10		-	-	0.78	-	medium
S	723	DLPVITIDPASPQSPESVDLV	MAPK14	11604491	LTP	1.00	MOD_ProDKin_1	-	-	0.73	-	medium
S	726	VITIDPASPQSPESVDLVNEE	MAPK14	11604491	LTP	0.30	MOD_ProDKin_1	-	-	0.73	-	medium
S	729	IDPASPQSPESVDLVNEELKG	MAPK14	11604491	LTP	0.11	MOD_ProDKin_1	-	-	0.75	-	medium

Substrate:

STAT 4 (Signal transducer and activator of transcription 4)

Seq-ID:

P42228 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, calcium ion binding, sequence-specific DNA binding transcription factor activity, signal transducer activity	cytoplasm, nucleus	protein amino acid phosphorylation, transcription, cytokine-mediated signaling pathway, regulation of transcription, DNA-dependent, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	722	PQSPSDLLPMSPSAYAVLREN	MAPK14	10961885	LTP	0.90	MOD_ProDKin_1	-	-	0.49	-	low

Substrate:

TAK1-binding protein 1 (Possible signaling intermediate between TGFB receptors and MAP3K7/TAK1)

Seq-ID:

Q15750 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-17884   MK14_HUMAN
MINT-49160   HS71L_HUMAN
MINT-49161   HSP74_HUMAN
MINT-49162   GRP78_HUMAN
MINT-49163   HSP7C_HUMAN
MINT-49164   GRP75_HUMAN
MINT-49166   DNJA1_HUMAN
MINT-49171   HS74L_HUMAN
MINT-49173   CALM_HUMAN
MINT-49174   TBB5_HUMAN
MINT-49175   TBB4_HUMAN
MINT-49176   IRAK1_HUMAN
MINT-49177   HS90A_HUMAN
MINT-49180   DNJC7_HUMAN
MINT-49181   HS90B_HUMAN
MINT-49195   TAB2_HUMAN
MINT-2842623   M3K7_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
catalytic activity, protein binding	endosome membrane	activation of MAPKKK activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	423	SQGQMVNGAHSASTLDEATPT	MAPK14	14592977	LTP	1.00		-	-	0.75	-	medium
T	431	AHSASTLDEATPTLTNQSPTL	MAPK14	14592977	LTP	0.95	MOD_ProDKin_1	-	-	0.77	-	medium
S	438	DEATPTLTNQSPTLTLQSTNT	MAPK14	14592977	LTP	0.97	MOD_ProDKin_1	-	-	0.82	-	medium

Substrate:

Transcription factor jun-B (Transcription factor)

Seq-ID:

P17275 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-61982   SMAD4_HUMAN
MINT-68818   VE7_HPV16
MINT-1788374   FOS_HUMAN
MINT-1788416   ATF2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein dimerization activity, RNA polymerase II transcription factor activity, transcription corepressor activity, transcription coactivator activity	chromatin, nucleus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	79	FSGQGSDTGASLKLASSELER	MAPK14	15308641	LTP	0.04		-	Jun	0.54	-	low