Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Bcl-2-like protein 11
C-ets-2 protein
c-Jun
Forkhead box protein O4
Histone H3.3
jdp2
JNK-interacting protein 1
MAPKAPK5
NFAT4
RRN3

Substrate:

Bcl-2-like protein 11 (Unclassified)

Seq-ID:

O43521-2 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-4980380 MCL1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein binding	plasma membrane, mitochondrion, cytosol, endomembrane system	induction of apoptosis by extracellular signals, activation of pro-apoptotic gene products

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	56	APMSCDKSTQTPSPPCQAFNH	MAPK9	12591950	LTP	1.00	MOD_ProDKin_1	-	-	0.64	-	medium

Substrate:

Bcl-2-like protein 11 (Unclassified)

Seq-ID:

O54918 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13660   BCL2_HUMAN
MINT-13878   B2CL1_HUMAN
MINT-17381   MCL1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
microtubule binding	mitochondrion, peripheral to membrane of membrane fraction, membrane	B cell apoptosis, post-embryonic organ morphogenesis, male gonad development, thymus development, kidney development, in utero embryonic development, positive regulation of apoptosis, regulation of developmental pigmentation, tube formation, B cell homeostasis, cell-matrix adhesion, regulation of organ growth, spermatogenesis, T cell homeostasis, mammary gland development, myeloid cell homeostasis, odontogenesis of dentine-containing tooth, developmental pigmentation, spleen development, ear development

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	55	DGEGDRCPHGSPQGPLAPPAS	MAPK9	12818176	LTP	0.29	MOD_ProDKin_1	-	-	0.95	-	medium
S	65	SPQGPLAPPASPGPFATRSPL	MAPK9	12818176	LTP	0.94	MOD_ProDKin_1	PIN1 WW	-	0.80	-	medium
S	73	PASPGPFATRSPLFIFVRRSS	MAPK9	12818176	LTP	1.00	MOD_ProDKin_1	-	-	0.50	-	medium

Substrate:

C-ets-2 protein (Transcription factor)

Seq-ID:

P15037 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding	nucleus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	72	DSASCELPLLTPCSKAVMSQA	MAPK9	11027273	LTP	1.00	MOD_ProDKin_1	-	-	0.22	-	medium

Substrate:

c-Jun (c-Jun (Transcription factor AP-1))

Seq-ID:

P05412 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14077   DDX21_HUMAN
MINT-68803   VE7_HPV16
MINT-68804   FOS_HUMAN
MINT-6628041   ATF2_HUMAN
MINT-6628056   CITE1_HUMAN
MINT-7148314   MK08_HUMAN
MINT-7148323   MK09_HUMAN
MINT-7148332   MK10_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription repressor activity, R-SMAD binding, RNA polymerase II transcription factor activity, enhancer binding, Rho GTPase activator activity, transcription coactivator activity, promoter binding		SMAD protein nuclear translocation, positive regulation by host of viral transcription, SMAD protein signal transduction, negative regulation of DNA binding, transforming growth factor beta receptor signaling pathway, positive regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	63	LRAKNSDLLTSPDVGLLKLAS	MAPK9	11948398	LTP	1.00	MOD_ProDKin_1	PIN1 WW	Jun	0.43	-	-

Substrate:

Forkhead box protein O4 (Putative fork head domain transcription factor AFX1 (Forkhead box protein O4))

Seq-ID:

P98177 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7299691 OGT1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
enzyme binding, transcription factor binding, sequence-specific DNA binding transcription factor activity	cytosol, nucleus	transcription from RNA polymerase II promoter, negative regulation of angiogenesis, G1 phase of mitotic cell cycle, negative regulation of cell proliferation, cell cycle arrest, negative regulation of smooth muscle cell differentiation, muscle organ development, regulation of transcription, DNA-dependent, cell differentiation, insulin receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	451	ASAPIPKALGTPVLTPPTEAA	MAPK9	15538382	LTP	0.01	MOD_ProDKin_1	-	-	0.68	-	medium
T	455	IPKALGTPVLTPPTEAASQDR	MAPK9	15538382	LTP	0.49	MOD_ProDKin_1	-	-	0.78	-	medium

Substrate:

Histone H3.3 (DNA binding protein)

Seq-ID:

P84245 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding	nucleus, nucleosome	brain development, nucleosome assembly, response to hormone stimulus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	29	KQLATKAARKSAPSTGGVKKP	MAPK9	11278789	LTP	0.70		-	-	0.70	-	medium

Substrate:

jdp2 (protein dimerization activity, sequence-specific DNA binding)

Seq-ID:

ENSP00000267569 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14001   ATF2_MOUSE
MINT-4788079   PRGR_HUMAN
MINT-6699850   I2BP1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding	nucleus	transcription

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	148	TCIVRTDSVKTPESEGNPLLE	MAPK9	12225289	LTP	1.00	MOD_ProDKin_1	-	-	0.63	-	low

Substrate:

JNK-interacting protein 1 (Transcription factor)

Seq-ID:

Q9UQF2 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14547   A4_HUMAN
MINT-45956   ITB2_HUMAN
MINT-45957   ITB3_HUMAN
MINT-45958   ITB7_HUMAN
MINT-45971   A4_MOUSE
MINT-63239   RECQ5_HUMAN
MINT-74572   EGFR_HUMAN
MINT-74575   ERBB2_HUMAN
MINT-6629291   M3K7_HUMAN
MINT-6629296   MP2K7_HUMAN
MINT-6629301   MK08_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase inhibitor activity, MAP-kinase scaffold activity, kinesin binding	nucleus, perinuclear region of cytoplasm	vesicle-mediated transport

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	103	QMDLIDATGDTPGAEDDEEDD	MAPK9	15911620	LTP	0.11	MOD_ProDKin_1	-	-	0.93	-	low

Substrate:

MAPKAPK5 (MAP kinase kinase activity, protein serine/threonine kinase activity)

Seq-ID:

Q8IW41 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, MAP kinase kinase activity, ATP binding, protein binding	cytoplasm, nucleus	protein amino acid phosphorylation, signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	182	FAKIDQGDLMTPQFTPYYVAP	MAPK9	9628874	LTP	0.02	MOD_ProDKin_1	-	S_TKc	0.18	-	medium

Substrate:

NFAT4 (Nuclear factor of activated T-cells, GO:0005737ic 3 (T cell transcription factor NFAT4) (NF-ATc3) (NF-AT4))

Seq-ID:

Q12968 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	cytoplasm, nucleus	transcription from RNA polymerase II promoter, inflammatory response

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	163	LEPSYRESSLSPSPASSISSR	MAPK9	9374467	LTP	0.20	MOD_ProDKin_1	-	-	0.56	-	low
S	165	PSYRESSLSPSPASSISSRSW	MAPK9	9374467	LTP	1.00	MOD_ProDKin_1	-	-	0.54	-	low

Substrate:

RRN3 (Transcription initiation factor)

Seq-ID:

Q9NYV6 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-4544044 SET_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	nucleolus, nucleoplasm	transcription, regulation of transcription

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	200	LQIIARYVPSTPWFLMPILVE	MAPK9	15805466	LTP	0.87	MOD_ProDKin_1	-	RRN3	0.03	-	medium