List of substrates found:


Substrate: Caldesmon (Actin and myosin binding protein)
Seq-ID: P12957 [Gallus gallus]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
myosin binding,
actin binding,
calmodulin binding		 myofibril muscle contraction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 672 VPAEGVRNIKSMWEKGNVFSS PAK3 10636898
LTP
1.00
 - Caldesmon
0.58
 - low
S 702 ETAGLKVGVSSRINEWLTKTP PAK3 10636898
LTP
1.00
 - Caldesmon
0.58
 - low

Substrate: Myosin-VI (Structural protein)
Seq-ID: Q64331 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ATP binding,
actin binding,
calmodulin binding,
motor activity		 plasma membrane,
neuronal cell body,
myosin complex,
cytoplasmic membrane-bounded vesicle,
coated pit,
Golgi apparatus,
nucleus,
axon,
perinuclear region of cytoplasm,
ruffle,
vesicle membrane		 dendrite development,
sensory perception of sound,
regulation of synaptic plasticity,
inner ear morphogenesis,
synapse assembly,
glutamate secretion,
locomotory behavior,
protein targeting,
synaptic transmission,
endocytosis,
auditory receptor cell differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 406 MLTTAGGTKGTVIKVPLKVEQ PAK3 11517222
LTP
1.00
 - MYSc
0.29
 - low

Substrate: PAK3 (Serine/threonine kinase)
Seq-ID: O75914-2 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
protein serine/threonine kinase activity,
metal ion binding,
ATP binding		 protein amino acid phosphorylation,
multicellular organismal development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 139 KETVNNQKYMSFTSGDKSAHG PAK3 11278486
LTP
0.58
 - -
0.64
 - medium
T 421 QITPEQSKRSTMVGTPYWMAP PAK3 11278486
LTP
1.00
 - S_TKc
0.37
 - medium

Substrate: Raf1 (RAF proto-oncogene serine/threonine-protein kinase)
Seq-ID: P04049 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19324   KPYM_HUMAN
MINT-24923   RAP1A_HUMAN
MINT-45800   1433Z_HUMAN
MINT-51053   K1C19_HUMAN
MINT-51055   K1C18_HUMAN
MINT-51056   K2C8_HUMAN
MINT-56513   CNKR1_HUMAN
MINT-3389399   PAK1_HUMAN
MINT-3389607   PEBP1_HUMAN
MINT-3975386   1433S_HUMAN
MINT-6946517   RASH_HUMAN
MINT-7014370   MP2K1_HUMAN
MINT-7014449   AKT1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
metal ion binding,
receptor signaling protein activity,
ATP binding,
protein binding		 plasma membrane,
cytosol,
mitochondrial outer membrane		 protein amino acid phosphorylation,
negative regulation of cell proliferation,
apoptosis,
Ras protein signal transduction,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 338 NKIRPRGQRDSSYYWEIEASE PAK3 9823899
LTP
0.96
 - -
0.43
 - medium

Substrate: Src substrate cortactin (Involved in the organization of cell structure)
Seq-ID: Q60598 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-58249   WIPF1_MOUSE
MINT-58757   LYN_MOUSE
MINT-6765355   PTN1_HUMAN
MINT-7103326   KCMA1_MOUSE
MINT-7146457   DYN2_HUMAN
MINT-7306926   MTSS1_HUMAN
MINT-7739614   UBIQ_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding lamellipodium,
cytoskeleton,
cell cortex,
ruffle
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 113 EYQSKLSKHCSQVDSVRGFGG PAK3 16854367
LTP
1.00
 - HS1_rep
0.43
 - medium
S 150 EYQGKTEKHASQKDYSSGFGG PAK3 16854367
LTP
1.00
 - HS1_rep
0.51
 - medium
S 282 KFGVQSERQDSSAVGFDYKER PAK3 16854367
LTP
0.09
 - HS1_rep
0.47
 - medium

Substrate: Troponin I, cardiac muscle (troponin I, cardiac muscle (from PhosphoBase))
Seq-ID: P19429 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium-dependent protein binding,
troponin T binding,
protein kinase binding,
protein domain specific binding,
troponin C binding,
calcium channel inhibitor activity,
actin binding		 troponin complex regulation of systemic arterial blood pressure by ischemic conditions,
negative regulation of ATPase activity,
cellular calcium ion homeostasis,
cardiac muscle contraction,
vasculogenesis,
ventricular cardiac muscle tissue morphogenesis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 150 KRPTLRRVRISADAMMQALLG PAK3 12242269
LTP
1.00
 - Troponin
0.36
 1J1D 53.28%

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