List of substrates found:


Substrate: Merlin (Probably acts as a ,15, stabilizing protein)
Seq-ID: P35240 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytoskeletal protein binding early endosome,
cytoskeleton,
nucleolus,
ruffle membrane,
extrinsic to membrane,
perinuclear region of cytoplasm,
filopodium membrane		 negative regulation of DNA replication,
actin cytoskeleton organization,
negative regulation of tyrosine phosphorylation of Stat5 protein,
positive regulation of stress fiber assembly,
negative regulation of cell proliferation,
regulation of hippo signaling cascade,
negative regulation of cell-matrix adhesion,
Schwann cell proliferation,
negative regulation of cell-cell adhesion,
negative regulation of cell migration,
negative regulation of tyrosine phosphorylation of Stat3 protein
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 518 DFKDTDMKRLSMEIEKEKVEY PAK_group 11719502
LTP
1.00
 MOD_PKA_1
 - COIL
0.46
 - medium

Substrate: Raf1 (RAF proto-oncogene serine/threonine-protein kinase)
Seq-ID: P04049 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19324   KPYM_HUMAN
MINT-24923   RAP1A_HUMAN
MINT-45800   1433Z_HUMAN
MINT-51053   K1C19_HUMAN
MINT-51055   K1C18_HUMAN
MINT-51056   K2C8_HUMAN
MINT-56513   CNKR1_HUMAN
MINT-3389399   PAK1_HUMAN
MINT-3389607   PEBP1_HUMAN
MINT-3975386   1433S_HUMAN
MINT-6946517   RASH_HUMAN
MINT-7014370   MP2K1_HUMAN
MINT-7014449   AKT1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
metal ion binding,
receptor signaling protein activity,
ATP binding,
protein binding		 plasma membrane,
cytosol,
mitochondrial outer membrane		 protein amino acid phosphorylation,
negative regulation of cell proliferation,
apoptosis,
Ras protein signal transduction,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 338 NKIRPRGQRDSSYYWEIEASE PAK_group 11376654
LTP
0.96
 - -
0.43
 - medium
S 338 NKIRPRGQRDSSYYWEIEASE PAK_group 9823899
LTP
0.96
 - -
0.43
 - medium

Substrate: Synapsin-1 (Synapsin I (Brain protein 4.1))
Seq-ID: P17600 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-63519   VIME_HUMAN
MINT-63520   KAT5_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
catalytic activity,
ATP binding,
actin binding,
transporter activity		 cell junction,
Golgi apparatus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 605 PGPAGPTRQASQAGPVPRTGP PAK_group 12237306
LTP
0.26
 - -
0.99
 - medium

Substrate: Vimentin (vimentin (from PhosphoBase))
Seq-ID: P08670 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-48218   NEMO_HUMAN
MINT-48335   M3K1_HUMAN
MINT-48490   M3K3_HUMAN
MINT-48555   NFKB1_HUMAN
MINT-49072   RIPK2_HUMAN
MINT-49446   TNR1B_HUMAN
MINT-51249   SMAD3_HUMAN
MINT-63478   FABP4_HUMAN
MINT-63483   CREB1_HUMAN
MINT-63519   SYN1_HUMAN
MINT-64054   RAD51_HUMAN
MINT-64131   TIF1B_HUMAN
MINT-64137   NFAC2_HUMAN
MINT-64185   CASP8_HUMAN
MINT-64286   STX1A_HUMAN
MINT-64820   Q86V38_HUMAN
MINT-64930   SIRT6_HUMAN
MINT-64945   CA103_HUMAN
MINT-64988   PAIRB_HUMAN
MINT-65109   FUBP1_HUMAN
MINT-65490   TARA_HUMAN
MINT-65741   PUF60_HUMAN
MINT-65855   SRRT_HUMAN
MINT-65878   NS1BP_HUMAN
MINT-66105   MYST2_HUMAN
MINT-66208   ABLM1_HUMAN
MINT-66844   K1C20_HUMAN
MINT-66894   GFAP_HUMAN
MINT-67503   PDLI1_HUMAN
MINT-67553   PSA1_HUMAN
MINT-67944   GOPC_HUMAN
MINT-2515544   SYUA_HUMAN
MINT-2791056   RD23A_HUMAN
MINT-2791422   RD23B_HUMAN
MINT-2985160   ZO1_HUMAN
MINT-3297793   1433Z_HUMAN
MINT-3979536   CHD3_HUMAN
MINT-3979774   ZHX1_HUMAN
MINT-3980301   SETB1_HUMAN
MINT-3980318   NFL_HUMAN
MINT-3980438   ING5_HUMAN
MINT-3980472   PPHLN_HUMAN
MINT-3980489   UT14A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein C-terminus binding,
structural constituent of cytoskeleton		 intermediate filament,
cytosol		 cellular component movement,
interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 26 GGPGTASRPSSSRSYVTTSTR PAK_group 11895474
LTP
0.73
 - Filament_head
0.66
 --
S 39 SYVTTSTRTYSLGSALRPSTS PAK_group 11895474
LTP
0.71
 - Filament_head
0.49
 --
S 51 GSALRPSTSRSLYASSPGGVY PAK_group 11895474
LTP
0.61
 - Filament_head
0.47
 --
S 56 PSTSRSLYASSPGGVYATRSS PAK_group 16997882
LTP
0.61
 MOD_ProDKin_1
 - Filament_head
0.48
 --
S 56 PSTSRSLYASSPGGVYATRSS PAK_group 16990256
LTP
0.61
 MOD_ProDKin_1
 - Filament_head
0.48
 --
S 66 SPGGVYATRSSAVRLRSSVPG PAK_group 11895474
LTP
0.73
 - Filament_head
0.44
 --
S 73 TRSSAVRLRSSVPGVRLLQDS PAK_group 11895474
LTP
0.87
 - Filament_head
0.38
 --

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