Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Glycogen phosphorylase, brain form
Glycogen phosphorylase, muscle form
Phosphorylase b kinase alpha regulatory chain, skeletal muscle isoform
Phosphorylase kinase gamma subunit 1
tau
Troponin I, cardiac muscle
Troponin I, fast skeletal muscle
Troponin T, fast skeletal muscle

Substrate:

Glycogen phosphorylase, brain form (Glycogen phosphorylase)

Seq-ID:

P11216 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
pyridoxal phosphate binding, glycogen phosphorylase activity	cytoplasm	glycogen catabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	15	LTDSEKRKQISVRGLAGLGDV	PHK_group	9362479	LTP	1.00	MOD_PK_1	-	-	0.34	-	medium

Substrate:

Glycogen phosphorylase, muscle form (glycogen phosphorylase, muscle form (from PhosphoBase))

Seq-ID:

P11217 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-48500 M3K3_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
glycogen phosphorylase activity, protein binding	cytosol

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	15	LSDQEKRKQISVRGLAGVENV	PHK_group	1140412	LTP	1.00	MOD_PK_1	-	-	0.43	1Z8D	100.82%

Substrate:

Phosphorylase b kinase alpha regulatory chain, skeletal muscle isoform (Enzyme: Phosphorylase)

Seq-ID:

P18688 [Oryctolagus cuniculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calmodulin binding, glucan 1,4-alpha-glucosidase activity	plasma membrane	glycogen metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	972	LSGKEFGVERSVRPTDSNVSP	PHK_group	2108025	LTP	1.00	-	PHK_AB	0.51	-	low
S	985	PTDSNVSPAISIHEIGAVGAT	PHK_group	2108025	LTP	1.00	-	PHK_AB	0.46	-	low
S	1007	TERTGIMQLKSEIKQVEFRRL	PHK_group	2108025	LTP	0.90	-	PHK_AB	0.38	-	low

Substrate:

Phosphorylase b kinase alpha regulatory chain, skeletal muscle isoform (Enzyme: Phosphorylase)

Seq-ID:

P46020 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calmodulin binding, glucan 1,4-alpha-glucosidase activity, phosphorylase kinase activity	plasma membrane, cytoplasm, intracellular membrane-bounded organelle	glycogen metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	972	LSGKEFGVERSVRPTDSNVSP	PHK_group	10487978	LTP	1.00		-	PHK_AB	0.50	-	medium
S	985	PTDSNVSPAISIHEIGAVGAT	PHK_group	10487978	LTP	1.00		-	PHK_AB	0.44	-	medium
S	1007	TERTGIMQLKSEIKQVEFRRL	PHK_group	10487978	LTP	0.90		-	PHK_AB	0.37	-	medium
S	1018	EIKQVEFRRLSISAESQSPGT	PHK_group	10487978	LTP	0.44	MOD_PK_1	-	PHK_AB	0.48	-	medium
S	1018	EIKQVEFRRLSISAESQSPGT	PHK_group	10937878	LTP	0.44	MOD_PK_1	-	PHK_AB	0.48	-	medium

Substrate:

Phosphorylase kinase gamma subunit 1 (Phosphorylase kinase gamma)

Seq-ID:

Q16816 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ATP binding, calmodulin binding, phosphorylase kinase activity		glycogen biosynthetic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	31	EPKEILGRGVSSVVRRCIHKP	PHK_group	7935360	LTP	1.00		-	S_TKc	0.33	-	low
S	82	LKEVDILRKVSGHPNIIQLKD	PHK_group	7935360	LTP	0.72		-	S_TKc	0.23	-	low

Substrate:

tau (Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau))

Seq-ID:

P10636-8 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-74872 KS6B1_HUMAN
MINT-6174455 DCTN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
apolipoprotein E binding, SH3 domain binding, lipoprotein binding, identical protein binding, structural constituent of cytoskeleton, enzyme binding, microtubule binding	plasma membrane, cytosol, microtubule associated complex, tubulin complex, axon, growth cone, microtubule	positive regulation of microtubule polymerization, superior temporal gyrus development, negative regulation of microtubule depolymerization, positive regulation of axon extension, microtubule cytoskeleton organization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	237	AVVRTPPKSPSSAKSRLQTAP	PHK_group	8999860	LTP	0.42	-	-	0.89	-	medium
S	262	DLKNVKSKIGSTENLKHQPGG	PHK_group	8999860	LTP	1.00	-	Tubulin-binding	0.83	-	medium
S	285	VQIINKKLDLSNVQSKCGSKD	PHK_group	8999860	LTP	0.91	-	Tubulin-binding	0.55	-	medium
S	305	DNIKHVPGGGSVQIVYKPVDL	PHK_group	8999860	LTP	0.21	-	Tubulin-binding	0.52	-	medium
S	352	EKLDFKDRVQSKIGSLDNITH	PHK_group	8999860	LTP	0.77	-	Tubulin-binding	0.46	-	medium

Substrate:

Troponin I, cardiac muscle (troponin I, cardiac muscle (from PhosphoBase))

Seq-ID:

P02646 [Oryctolagus cuniculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

Molecular Function	Cellular Component	Biological Process
actin binding

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	77	ERRGEKGRALSTRCQPLELAG	PHK_group	157897	LTP	0.20		-	Troponin	0.49	-	medium

Substrate:

Troponin I, fast skeletal muscle (troponin I, fast skeletal muscle (from PhosphoBase))

Seq-ID:

P02643 [Oryctolagus cuniculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
troponin T binding, actin binding

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	12	GDEEKRNRAITARRQHLKSVM	PHK_group	157897	LTP	0.04		-	-	0.60	1A2X	43.15%

Substrate:

Troponin T, fast skeletal muscle (troponin T, fast skeletal muscle isoform (from PhosphoBase))

Seq-ID:

P02641 [Oryctolagus cuniculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	2	MSDEEVEHVEEQ	PHK_group	849266	LTP	-	-	-	0.65	-	medium
S	170	EDLKKKKALSSMGANYSSYLA	PHK_group	849266	LTP	0.25	-	COIL	0.47	-	medium
S	177	ALSSMGANYSSYLAKADQKRG	PHK_group	849266	LTP	0.28	-	Troponin	0.55	-	medium