a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

Substrate:	PI3-kinase p85-alpha subunit (Adaptor molecule. Phopshatidylinositol 3-kinase regulatory alpha subunit.)
Seq-ID:	P27986 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-16109   ARAF_HUMAN MINT-17501   SHC1_HUMAN MINT-19009   CDC42_HUMAN MINT-56732   KSYK_HUMAN MINT-56734   KSYK_MOUSE MINT-65974   GRB2_HUMAN MINT-66003   LCK_HUMAN MINT-68496   GAB2_HUMAN MINT-68500   CBL_HUMAN MINT-68735   IRS1_HUMAN MINT-74606   EGFR_HUMAN MINT-74610   ERBB2_HUMAN MINT-74617   ERBB3_HUMAN MINT-1893011   GAB1_HUMAN MINT-2840114   TLR3_HUMAN MINT-3378272   SEPT2_HUMAN MINT-6762880   IRS1_RAT MINT-7103574   FLT3_HUMAN MINT-7103638   MK08_HUMAN MINT-7103655   CRKL_HUMAN MINT-7251262   ICAL_HUMAN MINT-7251286   SNX17_HUMAN MINT-7251334   DAB2_HUMAN MINT-7251346   CDC27_HUMAN MINT-7251370   FLNA_HUMAN MINT-7251382   SYNJ2_HUMAN MINT-7251406   CSDE1_HUMAN MINT-7251418   ABL1_HUMAN MINT-7251430   SUV92_HUMAN MINT-7251442   VP13A_HUMAN MINT-7251454   FLNB_HUMAN MINT-7251526   SOS1_HUMAN MINT-7251538   ASAP2_HUMAN MINT-7251550   LIPA3_HUMAN MINT-7251562   AKAP2_HUMAN MINT-7251574   ARHGB_HUMAN MINT-7251598   PHAR2_HUMAN MINT-7251610   DLGP4_HUMAN MINT-7251622   ELK3_HUMAN MINT-7251658   BRCA1_HUMAN MINT-7251706   CKAP5_HUMAN MINT-7251718   RRAS_HUMAN MINT-7251730   ECT2_HUMAN MINT-7251754   TPX2_HUMAN MINT-7251766   JAK2_HUMAN MINT-7251778   ASAP1_HUMAN MINT-7251790   FLNC_HUMAN MINT-7251802   DNLI3_HUMAN MINT-7251814   TGON2_HUMAN MINT-7251838   SHAN2_HUMAN MINT-7251850   KI13A_HUMAN MINT-7251862   ABL2_HUMAN MINT-7251886   BRPF3_HUMAN MINT-7251898   SH3K1_HUMAN MINT-7251934   MYRIP_HUMAN MINT-7251982   DAG1_HUMAN MINT-7251994   STF1_HUMAN MINT-7252006   P3C2B_HUMAN MINT-7252018   SNX8_HUMAN MINT-7252030   BRD4_HUMAN MINT-7252078   MINT_HUMAN MINT-7252126   PLCG2_HUMAN MINT-7252150   MAP4_HUMAN MINT-7252174   MYLK_HUMAN MINT-7252186   PEBP1_HUMAN MINT-7252234   CAF1A_HUMAN MINT-7252258   DTBP1_HUMAN MINT-7252270   NELFB_HUMAN MINT-7252282   AKAP6_HUMAN MINT-7252294   FANCA_HUMAN MINT-7252318   GHR_HUMAN MINT-7252330   M4K1_HUMAN MINT-7252342   RPGF1_HUMAN MINT-7296136   SRC_HUMAN MINT-7306624   LCP2_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process ErbB-3 class receptor binding, insulin-like growth factor receptor binding, phosphoinositide 3-kinase regulator activity, insulin binding, insulin receptor binding, insulin receptor substrate binding, phosphatidylinositol binding, protein phosphatase binding 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex phosphoinositide 3-kinase cascade, insulin-like growth factor receptor signaling pathway, phosphoinositide phosphorylation, interspecies interaction between organisms, positive regulation of establishment of protein localization in plasma membrane, insulin receptor signaling pathway, positive regulation of glucose import, growth hormone receptor signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	608	LGNENTEDQYSLVEDDEDLPH	PIK3CA	9446654	LTP	1.00		-	-	0.58	-	-
S	608	LGNENTEDQYSLVEDDEDLPH	PIK3CA	14729945	LTP	1.00		-	-	0.58	-	-

Substrate:	Tropomyosin 1 alpha (tropomyosin alpha chain, skeletal and cardiac muscle (from PhosphoBase))
Seq-ID:	P09493 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process structural constituent of cytoskeleton, structural constituent of muscle, actin binding bleb, stress fiber, ruffle membrane, muscle thin filament tropomyosin positive regulation of ATPase activity, positive regulation of stress fiber assembly, cellular component movement, positive regulation of cell adhesion, regulation of muscle contraction, cardiac muscle contraction, ventricular cardiac muscle tissue morphogenesis, negative regulation of cell migration, sarcomere organization, cellular response to reactive oxygen species, wound healing, muscle filament sliding, ruffle organization, positive regulation of heart rate by epinephrine
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	61	KGTEDELDKYSEALKDAQEKL	PIK3CA	16094730	LTP	0.85		-	COIL	0.56	2TMA	0.0%