Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Substrate:

Acetyl-CoA carboxylase 1 (Enzyme: Carboxylase)

Seq-ID:

Q13085 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
metal ion binding, acetyl-CoA carboxylase activity, biotin carboxylase activity, ATP binding, protein binding		fatty acid biosynthetic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	78	QDGLALHIRSSMSGLHLVKQG	PKA_alpha	7907095	LTP	0.16	MOD_PKA_2	-	-	0.28	-	medium
S	1201	RGNIPTLNRMSFSSNLNHYGM	PKA_alpha	2900138	LTP	0.84	MOD_PKA_2	-	ACC_central	0.30	-	medium

Substrate:

c-Mos (Serine/threonine kinase)

Seq-ID:

P00536 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding		protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	72	LSPSVDSRSCSIPLVAPRKAG	PKA_alpha	8622681	LTP	1.00		-	-	0.31	-	low
S	279	KLQVLRCRQASPHHIGGTYTH	PKA_alpha	8622681	LTP	0.18		-	STYKc	0.27	-	low

Substrate:

cAMP-dependent protein kinase, alpha-catalytic subunit (cAMP-dependent protein kinase)

Seq-ID:

P05132 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-4051315 PDE3A_MOUSE
MINT-7211789 LIPS_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cAMP-dependent protein kinase activity, ATP binding	plasma membrane, mitochondrion, neuromuscular junction, cytosol, nucleoplasm	mesoderm formation, positive regulation of protein export from nucleus, protein amino acid autophosphorylation, cellular response to parathyroid hormone stimulus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	198	FAKRVKGRTWTLCGTPEYLAP	PKA_alpha	9707564	LTP	0.95		-	S_TKc	0.09	1RDQ	47.26%
S	339	DDYEEEEIRVSINEKCGKEFT	PKA_alpha	8395513	LTP	0.85	MOD_PKA_2	-	S_TK_X	0.30	1RDQ	47.54%

Substrate:

Common beta c subunit (Cytokine recpetor common beta chain)

Seq-ID:

P26955 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cytokine receptor activity	integral to membrane

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	603	GPYLGPPQSHSLPDLPDQLGS	PKA_alpha	16437163	LTP	1.00		-	-	0.87	-	medium

Substrate:

DARPP-32 (Dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32))

Seq-ID:

Q9UD71 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoprotein phosphatase inhibitor activity, protein kinase inhibitor activity	cytosol	signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	34	QVEMIRRRRPTPAMLFRLSEH	PKA_alpha	15726118	LTP	1.00		-	DARPP-32	0.74	-	low
T	34	QVEMIRRRRPTPAMLFRLSEH	PKA_alpha	11717349	LTP	1.00		-	DARPP-32	0.74	-	low

Substrate:

Doublecortin (Cytoskeletal associated protein)

Seq-ID:

O88809 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein binding	cytoplasm	brain development, neuron migration, axon extension, central nervous system projection neuron axonogenesis, dendrite morphogenesis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	47	FYRTRTLQALSNEKKAKKVRF	PKA_alpha	14741102	LTP	0.71		-	-	0.32	-	-

Substrate:

Engrailed 2 (Transcription factor)

Seq-ID:

P09066 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity	nucleus	neuron development, midbrain development, hindbrain development, positive regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	267	NRYLTEQRRQSLAQELSLNES	PKA_alpha	15196920	LTP	0.70	MOD_PKA_1	-	HOX	0.55	-	medium

Substrate:

GSK-3 beta (Glycogen synthase kinase-3 beta)

Seq-ID:

Q9WV60 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, tau-protein kinase activity, beta-catenin binding, ATP binding	neuronal cell body, Axin-APC-beta-catenin-GSK3B complex, cytosol, dendritic shaft, nucleoplasm, soluble fraction, growth cone	fat cell differentiation, myoblast fusion, organ morphogenesis, anti-apoptosis, positive regulation of peptidyl-serine phosphorylation, cell migration, protein export from nucleus, positive regulation of apoptosis, peptidyl-serine phosphorylation, canonical Wnt receptor signaling pathway, ER overload response, positive regulation of peptidyl-threonine phosphorylation, re-entry into mitotic cell cycle, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	9	MSGRPRTTSFAESCKPVQQ	PKA_alpha	11035810	LTP	0.70	MOD_PKA_2	-	-	0.61	-	-

Substrate:

Inositol 1,4,5-trisphosphate receptor type 1 (inositol 1,4,5-trisphosphate-binding protein type 1 receptor (from PhosphoBase))

Seq-ID:

P11881 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity, phosphoinositide binding, protein binding	nuclear inner membrane, sarcoplasmic reticulum, microsome, integral to membrane, nucleolus, endoplasmic reticulum membrane, calcineurin complex, postsynaptic density	response to hypoxia, endoplasmic reticulum calcium ion homeostasis, post-embryonic development, voluntary musculoskeletal movement

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1588	LSARNAARRDSVLAASRDYRN	PKA_alpha	14741364	LTP	0.92	MOD_PKA_1	-	-	0.26	-	-
S	1755	GNIRPSGRRESLTSFGNGPLS	PKA_alpha	14741364	LTP	0.48	MOD_PKA_1	-	-	0.64	-	-

Substrate:

Myocyte-specific enhancer factor 2C (Myocyte-specific enhancer factor 2C)

Seq-ID:

Q8CFN5 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19703   HDAC7_MOUSE
MINT-19713   TRIP6_MOUSE
MINT-19740   ACLY_MOUSE
MINT-19791   CTRO_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, transcription activator activity, histone deacetylase binding, sequence-specific DNA binding transcription factor activity	nucleus	nervous system development, outflow tract morphogenesis, transcription, smooth muscle cell differentiation, apoptosis, blood vessel remodeling, osteoblast differentiation, endochondral ossification, cardiac cell differentiation, cardiac ventricle formation, skeletal muscle tissue development, muscle cell fate determination, positive regulation of protein homodimerization activity, positive regulation of transcription from RNA polymerase II promoter, chondrocyte differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	20	RIMDERNRQVTFTKRKFGLMK	PKA_alpha	15735306	LTP	0.99		-	MADS	0.35	1EGW	22.60%

Substrate:

Neurabin II protein (Cytoskeletal protein)

Seq-ID:

Q6R891 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-4953730 RGS2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
actin binding	filopodium, dendritic spine, cell junction, cortical actin cytoskeleton, synapse, nucleus	dendrite development, actin filament organization, regulation of protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	94	PRASDRGVRLSLPRASSLNEN	PKA_alpha	16300646	LTP	1.00	MOD_PKA_2	-	-	0.76	-	low

Substrate:

NF-E2 (Transcription factor)

Seq-ID:

ENSMUSP00000074684 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, protein dimerization activity, sequence-specific DNA binding transcription factor activity	cytoplasm, nucleus	transcription, regulation of transcription, DNA-dependent

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	170	LEGMEAGRRRSEYADMYPVEY	PKA_alpha	9558374	LTP	0.22	MOD_PKA_1	-	-	0.50	-	low

Substrate:

p65 (Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit), RelA)

Seq-ID:

Q04207 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19530   IKBA_MOUSE
MINT-19560   IKBB_MOUSE
MINT-7288484   UBIQ_MOUSE
MINT-7288511   CUL2_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription activator activity, RNA polymerase II transcription factor activity, enhancer binding, chromatin binding	cytosol	transcription, organ morphogenesis, negative regulation of protein catabolic process, hair follicle development, liver development, positive regulation of interleukin-12 biosynthetic process, response to muramyl dipeptide

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	276	VRVSMQLRRPSDRELSEPMEF	PKA_alpha	9150141	LTP	1.00	MOD_PKA_1	-	IPT	0.57	1MY7	67.21%

Substrate:

Phospholamban (Integral membrane protein)

Seq-ID:

P61014 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium channel regulator activity, protein binding	sarcoplasmic reticulum, mitochondrial membrane, integral to membrane	cardiac muscle tissue development, cellular calcium ion homeostasis, regulation of calcium ion transport, regulation of the force of heart contraction, negative regulation of heart contraction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	16	YLTRSAIRRASTIEMPQQARQ	PKA_alpha	2544595	LTP	-	MOD_PKA_1	-	Phospholamban	0.12	-	-

Substrate:

Potassium voltage-gated channel subfamily D member 2 (Potassium channel protein)

Seq-ID:

Q9Z0V2 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

Molecular Function	Cellular Component	Biological Process
metal ion binding

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	38	PAPPRQERKRTQDALIVLNVS	PKA_alpha	10681507	LTP	0.11	MOD_PKA_1	-	-	0.46	-	-
S	552	NANVSGSHRGSVQELSTIQIR	PKA_alpha	10681507	LTP	0.56	MOD_PKA_2	-	-	0.50	-	-

Substrate:

Raf1 (RAF proto-oncogene serine/threonine-protein kinase)

Seq-ID:

Q99N57 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, metal ion binding, receptor signaling protein activity, ATP binding, protein binding	plasma membrane, cytosol	protein amino acid phosphorylation, apoptosis, nerve growth factor receptor signaling pathway, cytoskeleton organization, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	233	RMPASSQHRYSTPHAFTFNTS	PKA_alpha	11997508	LTP	0.80	MOD_PKA_2	-	-	0.56	-	medium

Substrate:

RASGRF1 (Ras guanyl-nucleotide exchange factor activity)

Seq-ID:

P27671 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-61289 NTRK3_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
Rho guanyl-nucleotide exchange factor activity, glutamate receptor binding	cytosol, growth cone	regulation of Rac protein signal transduction, regulation of neuronal synaptic plasticity, activation of Rac GTPase activity, neuron projection development, small GTPase mediated signal transduction, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	745	TSSPSRRRKLSLNIPIITGGK	PKA_alpha	11018028	LTP	0.97	MOD_PKA_1	-	RasGEFN	0.42	-	low
S	822	PGELSASRKHSSDVLKEESED	PKA_alpha	11018028	LTP	0.33	MOD_PKA_1	-	RasGEF_N	0.77	-	low
S	916	PSNKEVFRRMSLANTGFSSDQ	PKA_alpha	10601308	LTP	0.89	MOD_PKA_1	-	RasGEFN	0.50	-	low

Substrate:

Retinoic acid receptor alpha (Nuclear hormone receptor family)

Seq-ID:

P11416 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription repressor activity, retinoic acid receptor activity, zinc ion binding, promoter binding, sequence-specific DNA binding transcription factor activity, protein binding, steroid hormone receptor activity	neuronal cell body, dendrite, nucleus	negative regulation of cartilage development, positive regulation of cell proliferation, transcription, ureteric bud development, negative regulation of cell differentiation, regulation of granulocyte differentiation, spermatogenesis, chondroblast differentiation, ventricular cardiac muscle cell differentiation, cellular response to lipopolysaccharide, response to retinoic acid, positive regulation of transcription from RNA polymerase II promoter, negative regulation of transcription from RNA polymerase II promoter, negative regulation of translational initiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	369	LKVYVRKRRPSRPHMFPKMLM	PKA_alpha	7476969	LTP	0.24	MOD_PKA_1	-	HOLI	0.40	1DKF	81.15%

Substrate:

Serine/threonine-protein kinase 11 (Serine/threonine protein kinase 11)

Seq-ID:

Q9WTK7 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, LRR domain binding, ATP binding	cytoplasm, nucleus	protein amino acid phosphorylation, regulation of Wnt receptor signaling pathway, cell cycle arrest, canonical Wnt receptor signaling pathway, regulation of protein kinase B signaling cascade, negative regulation of epithelial cell proliferation involved in prostate gland development, tissue homeostasis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	431	VCSSNKIRRLSACKQQ	PKA_alpha	11297520	LTP	0.16	MOD_PKA_1	-	-	0.37	-	low

Substrate:

Spectrin beta chain, brain 1 (Cytoskeletal protein)

Seq-ID:

Q62261 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-19667 PLCG2_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
structural constituent of cytoskeleton, actin binding, calmodulin binding	plasma membrane, M band, spectrin, cuticular plate	SMAD protein nuclear translocation, actin filament capping, common-partner SMAD protein phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	346	GVQQQLQAFNTYRTVEKPPKF	PKA_alpha	9798950	LTP	0.96		-	SPEC	0.37	-	-

Substrate:

TEAD-1 (Transcription factor)

Seq-ID:

P30051 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription activator activity, sequence-specific DNA binding transcription factor activity, protein binding	transcription factor complex	transcription, heart development, positive regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	102	SHIQVLARRKSRDFHSKLKDQ	PKA_alpha	10931933	LTP	0.55	MOD_PKA_1	-	TEA	0.53	-	low

Substrate:

Troponin I, cardiac muscle (troponin I, cardiac muscle (from PhosphoBase))

Seq-ID:

P48787 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
actin binding		regulation of systemic arterial blood pressure by ischemic conditions, cellular calcium ion homeostasis, vasculogenesis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	23	QPAPAPVRRRSSANYRAYATE	PKA_alpha	7592712	LTP	0.18	MOD_PKA_1	-	-	0.73	-	-
S	24	PAPAPVRRRSSANYRAYATEP	PKA_alpha	7592712	LTP	0.18	MOD_PKA_1	-	-	0.72	-	-

Substrate:

Vimentin (vimentin (from PhosphoBase))

Seq-ID:

P20152 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19723 ARRB1_HUMAN
MINT-50699 KPCE_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	cytoplasm, type III intermediate filament, cell leading edge	intermediate filament-based process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	7	MSTRSVSSSSYRRMFGG	PKA_alpha	2500966	LTP	0.65		-	Filament_head	0.49	-	medium
S	7	MSTRSVSSSSYRRMFGG	PKA_alpha	2500966	LTP	0.65		-	Filament_head	0.49	-	medium
S	25	FGGSGTSSRPSSNRSYVTTST	PKA_alpha	2500966	LTP	0.68	MOD_PKA_2	-	Filament_head	0.68	-	medium
S	25	FGGSGTSSRPSSNRSYVTTST	PKA_alpha	2500966	LTP	0.68	MOD_PKA_2	-	Filament_head	0.68	-	medium