List of substrates found:


Substrate: Cyclic-AMP-dependent transcription factor ATF-2 (Transcription factor)
Seq-ID: P15336 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-1788416   JUNB_HUMAN
MINT-6628041   JUN_HUMAN
MINT-6628046   CITE1_HUMAN
MINT-6699865   I2BP1_HUMAN
MINT-7555703   HDAC4_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sequence-specific DNA binding,
protein dimerization activity,
RNA polymerase II transcription factor activity,
transcription coactivator activity,
zinc ion binding,
sequence-specific DNA binding transcription factor activity		 nucleoplasm transcription,
regulation of transcription, DNA-dependent
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 322 AHTTPQTQSTSGRRRRAANED PKC_beta 1661585
LTP
0.00
 - -
0.96
 --
S 322 AHTTPQTQSTSGRRRRAANED PKC_beta 1661585
LTP
0.00
 - -
0.96
 --
S 349 KFLERNRAAASRCRQKRKVWV PKC_beta 1661585
LTP
0.00
 - BRLZ
0.55
 1T2K 59.02%
S 349 KFLERNRAAASRCRQKRKVWV PKC_beta 1661585
LTP
0.00
 - BRLZ
0.55
 1T2K 59.02%

Substrate: DNA topoisomerase II, alpha (DNA topoisomerase II alpha)
Seq-ID: P11388 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-15316   PIN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase C binding,
DNA topoisomerase (ATP-hydrolyzing) activity,
protein heterodimerization activity,
protein C-terminus binding,
protein homodimerization activity,
DNA-dependent ATPase activity,
chromatin binding,
histone deacetylase binding,
ATP binding,
ubiquitin binding,
drug binding		 DNA topoisomerase complex (ATP-hydrolyzing),
cytoplasm,
chromosome,
nucleoplasm		 DNA repair,
chromosome segregation,
phosphoinositide-mediated signaling,
positive regulation of apoptosis,
DNA ligation,
apoptotic chromosome condensation,
DNA topological change,
DNA replication,
positive regulation of retroviral genome replication
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 1343 DEDFSDFDEKTDDEDFVPSDA PKC_beta 7499337
LTP
0.12
 MOD_CK2_1
 - -
0.73
 --

Substrate: FUS (protein binding, RNA binding)
Seq-ID: P35637 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15493   SF13A_HUMAN
MINT-16709   SFRS2_MOUSE
MINT-62324   ZMYM2_HUMAN
MINT-62325   SFPQ_HUMAN
MINT-63692   ANM1_HUMAN
MINT-73026   WBP4_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
RNA binding,
zinc ion binding,
protein binding		 nucleus RNA splicing,
cell death
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 257 GRGGRGGMGGSDRGGFNKFGG PKC_beta 10913197
LTP
0.01
 - -
0.78
 - medium

Substrate: Integrin beta 2 (Adhesion molecule)
Seq-ID: P05107 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-16748   CSN3_HUMAN
MINT-45894   SHC1_MOUSE
MINT-45897   EPS8_HUMAN
MINT-45904   RBGP1_HUMAN
MINT-45912   GULP1_HUMAN
MINT-45917   NUMB_MOUSE
MINT-45924   DAB1_MOUSE
MINT-45938   IRS1_RAT
MINT-45944   DOK1_MOUSE
MINT-45953   TLN1_MOUSE
MINT-45956   JIP1_HUMAN
MINT-50069   RANB9_HUMAN
MINT-4652127   RADI_HUMAN
MINT-4652150   CYH1_HUMAN
MINT-7226098   ABL1_HUMAN
MINT-7226365   TLN2_HUMAN
MINT-7226634   VAV_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor activity,
protein kinase binding,
glycoprotein binding		 integrin complex apoptosis,
integrin-mediated signaling pathway,
regulation of cell shape,
inflammatory response,
cell-cell signaling,
neutrophil chemotaxis,
cell-matrix adhesion,
regulation of peptidyl-tyrosine phosphorylation,
leukocyte cell-cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 745 YRRFEKEKLKSQWNNDNPLFK PKC_beta 11700305
LTP
0.13
 - Integrin_b_cyt
0.32
 --

Substrate: KCNC4 (voltage-gated potassium channel activity)
Seq-ID: Q03721 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
voltage-gated potassium channel activity,
protein binding		 voltage-gated potassium channel complex synaptic transmission
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 8    MISSVCVSSYRGRKSGNK PKC_beta 9649584
LTP
1.00
 - -
0.42
 --
S 9   MISSVCVSSYRGRKSGNKP PKC_beta 9649584
LTP
1.00
 - -
0.44
 --
S 15 VCVSSYRGRKSGNKPPSKTCL PKC_beta 9649584
LTP
0.25
 - -
0.47
 --
S 21 RGRKSGNKPPSKTCLKEEMAK PKC_beta 9649584
LTP
1.00
 - -
0.60
 --

Substrate: Lamin B1 (lamin B1 (from PhosphoBase))
Seq-ID: P20700 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-3297843   1433Z_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
structural molecule activity,
protein binding		 nuclear inner membrane,
lamin filament
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 395 EERLKLSPSPSSRVTVSRASS PKC_beta 8463284
LTP
1.00
 - -
0.63
 - low
S 405 SSRVTVSRASSSRSVRTTRGK PKC_beta 8463284
LTP
1.00
 - -
0.63
 - low
S 405 SSRVTVSRASSSRSVRTTRGK PKC_beta 8034666
LTP
1.00
 - -
0.63
 - low

Substrate: Mitogen-activated protein kinase 9 (Mitogen-activated protein kinase 9)
Seq-ID: Q9WTU6 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-19512   MK14_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
JUN kinase activity,
ATP binding,
protein binding		 nucleus induction of apoptosis in response to chemical stimulus,
response to cadmium ion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 129 IHMELDHERMSYLLYQMLCGI PKC_beta 16061178
LTP
1.00
 - S_TKc
0.02
 - low

Substrate: PKC alpha (Serine/threonine kinase)
Seq-ID: P20444 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-4545254   CLOCK_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium-dependent protein kinase C activity,
ATP binding,
zinc ion binding,
protein binding		 plasma membrane,
mitochondrion,
nucleus		 positive regulation of protein amino acid phosphorylation,
inactivation of MAPK activity,
negative regulation of insulin receptor signaling pathway,
negative regulation of cell proliferation,
negative regulation of glucose import,
cellular calcium ion homeostasis,
neutrophil chemotaxis,
positive regulation of inflammatory response,
regulation of muscle contraction,
induction of apoptosis by intracellular signals,
induction of positive chemotaxis,
regulation of the force of heart contraction,
regulation of peptidyl-tyrosine phosphorylation,
chondrocyte differentiation,
negative regulation of protein amino acid phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 497 EHMMDGVTTRTFCGTPDYIAP PKC_beta 15364915
LTP
1.00
 - S_TKc
0.20
 - medium

Substrate: Ribosomal protein S6 kinase 2 (Ser/Thr protein kinase family)
Seq-ID: Q9UBS0 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15495   EF2K_HUMAN
MINT-51121   COASY_HUMAN
MINT-2833483   RS6_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding		 nucleoplasm positive regulation of translational initiation,
translation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 473 PIRPPSGTKKSKRGRGRPGR  PKC_beta 12529391
LTP
0.11
 - -
0.94
 - medium

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