Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

ICAM-3
Insulin receptor substrate 1
PKC theta
RASGRP3
STK39
WASP interacting protein

Substrate:

ICAM-3 (Adhesion molecule)

Seq-ID:

P32942 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
integrin binding	integral to plasma membrane	cell-cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	518	YVFREHQRSGSYHVREESTYL	PKC_theta	9268366	LTP	0.00		-	-	0.33	-	low

Substrate:

Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)

Seq-ID:

P35568 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19010   INSR_HUMAN
MINT-68735   P85A_HUMAN
MINT-74551   EGFR_HUMAN
MINT-74553   ERBB2_HUMAN
MINT-3975430   1433S_HUMAN
MINT-6628637   LT_SV40
MINT-6793745   PTN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoinositide 3-kinase binding, protein kinase C binding, insulin-like growth factor receptor binding, insulin receptor binding, transmembrane receptor protein tyrosine kinase docking protein activity, SH2 domain binding	microsome, caveola, cytosol, insulin receptor complex, nucleus	negative regulation of insulin receptor signaling pathway, glucose homeostasis, positive regulation of insulin receptor signaling pathway, positive regulation of fatty acid beta-oxidation, phosphoinositide 3-kinase cascade, negative regulation of insulin secretion, positive regulation of glycogen biosynthetic process, insulin receptor signaling pathway, positive regulation of glucose import, positive regulation of phosphoinositide 3-kinase activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1101	DPQGCRRRHSSETFSSTPSAT	PKC_theta	15364919	LTP	1.00		-	-	0.78	-	-

Substrate:

PKC theta (Serine/threonine kinase)

Seq-ID:

Q04759 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-4787821 MARK3_HUMAN
MINT-4787847 MALT1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase C activity, metal ion binding, ATP binding, protein binding		intracellular signaling pathway, protein amino acid phosphorylation, regulation of cell growth, membrane protein ectodomain proteolysis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	219	CTGSAINSRETMFHKERFKID	PKC_theta	16252004	LTP	1.00		-	-	0.29	-	-

Substrate:

RASGRP3 (calcium ion binding, diacylglycerol binding)

Seq-ID:

Q8IV61 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium ion binding, diacylglycerol binding, Rap GTPase activator activity, signal transducer activity	integral to plasma membrane	MAPKKK cascade, regulation of small GTPase mediated signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	133	IPSYDWMRRVTQRKKVSKKGK	PKC_theta	15657177	LTP	1.00		-	-	0.21	-	medium

Substrate:

STK39 (ATP binding, receptor signaling protein serine/threonine...)

Seq-ID:

Q9UEW8 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor signaling protein serine/threonine kinase activity, ATP binding	cytoplasm, nucleus	protein amino acid phosphorylation, response to stress

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	311	DKEMMKKYGKSFRKLLSLCLQ	PKC_theta	14988727	LTP	1.00		-	S_TKc	0.23	-	medium
S	325	LLSLCLQKDPSKRPTAAELLK	PKC_theta	14988727	LTP	0.65		-	S_TKc	0.33	-	medium

Substrate:

WASP interacting protein (Unclassified)

Seq-ID:

O43516 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-73064   WBP4_HUMAN
MINT-2748661   WASL_HUMAN
MINT-7246954   FYN_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
actin binding, profilin binding	cytoplasmic membrane-bounded vesicle	protein complex assembly, actin polymerization or depolymerization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	488	KLARNESRSGSNRRERGAPPL	PKC_theta	12504004	LTP	0.68		-	-	0.93	-	medium