List of substrates found:


Substrate: 14-3-3 beta/alpha (14-3-3 protein beta/alpha (protein kinase C inhibitor protein-1) (from PhosphoBase))
Seq-ID: P31946 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13707   KSR1_MOUSE
MINT-13962   RIN1_HUMAN
MINT-15934   TPD53_HUMAN
MINT-17162   TSC2_HUMAN
MINT-19367   KS6A1_HUMAN
MINT-24750   BID_HUMAN
MINT-25122   MPIP2_HUMAN
MINT-48491   M3K3_HUMAN
MINT-50344   BRAF_HUMAN
MINT-50346   HSP71_HUMAN
MINT-50347   PI4KB_HUMAN
MINT-50348   U520_HUMAN
MINT-50938   LBR_HUMAN
MINT-50939   SRPK1_HUMAN
MINT-50940   PRKDC_HUMAN
MINT-50943   AFAD_HUMAN
MINT-50945   LARP1_HUMAN
MINT-50946   FRYL_HUMAN
MINT-50947   CSK21_HUMAN
MINT-50948   TSC1_HUMAN
MINT-50949   P85B_HUMAN
MINT-50950   KINH_HUMAN
MINT-50951   UBP8_HUMAN
MINT-50952   SF13A_HUMAN
MINT-50953   ZO2_HUMAN
MINT-50954   STK38_HUMAN
MINT-50956   ACINU_HUMAN
MINT-50957   RABX5_HUMAN
MINT-50958   MYCB2_HUMAN
MINT-50959   C1QBP_HUMAN
MINT-50960   HS90B_HUMAN
MINT-50961   S4A7_HUMAN
MINT-50962   EDC3_HUMAN
MINT-50963   E41L3_HUMAN
MINT-50964   RMD3_HUMAN
MINT-50967   MEP50_HUMAN
MINT-50969   GRP78_HUMAN
MINT-50970   RIOK1_HUMAN
MINT-50971   SON_HUMAN
MINT-50972   TBB5_HUMAN
MINT-50973   PARD3_HUMAN
MINT-50974   SRRM2_HUMAN
MINT-50975   KIF23_HUMAN
MINT-50976   GAPD1_HUMAN
MINT-50977   ALS2_HUMAN
MINT-50978   RGAP1_HUMAN
MINT-50979   M3K2_HUMAN
MINT-50980   OSBL3_HUMAN
MINT-50981   MILK1_HUMAN
MINT-50982   MPRIP_HUMAN
MINT-50983   FRMD6_HUMAN
MINT-50984   MARK3_HUMAN
MINT-50985   PI3R4_HUMAN
MINT-50986   ST38L_HUMAN
MINT-50987   DOCK4_HUMAN
MINT-50988   WEE1_HUMAN
MINT-50991   KLC1_HUMAN
MINT-50992   LSR_HUMAN
MINT-50995   RAI14_HUMAN
MINT-50997   MYCPP_HUMAN
MINT-50998   Q8IXP7_HUMAN
MINT-50999   IRS2_HUMAN
MINT-51527   MARK2_HUMAN
MINT-7233039   IRK2_MOUSE
MINT-7300434   GAB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoserine binding,
protein domain specific binding,
histone deacetylase binding		 cytosol,
melanosome,
perinuclear region of cytoplasm		 cytoplasmic sequestering of protein,
negative regulation of protein amino acid dephosphorylation,
positive regulation of catalytic activity,
Ras protein signal transduction,
activation of pro-apoptotic gene products
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 132 KMKGDYFRYLSEVASGDNKQT PKC_zeta 10620507
LTP
0.16
 - 14_3_3
0.30
 2BQ0 0.82%

Substrate: Alpha adducin (Structural protein)
Seq-ID: P35611 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-72730   RFX1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
spectrin binding,
protein heterodimerization activity,
protein homodimerization activity,
metal ion binding,
transcription factor binding,
calmodulin binding,
actin filament binding		 plasma membrane,
cytosol,
F-actin capping protein complex,
nucleus		 positive regulation of protein binding,
actin filament bundle assembly,
barbed-end actin filament capping
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 726 SKKKKKFRTPSFLKKSKKKSD PKC_zeta 15611095
LTP
0.13
 - -
0.79
 - medium

Substrate: Aquaporin 9 (Water channel activity)
Seq-ID: O43315 [Homo sapiens]
Download:fasta csv
Interaction Network(s):
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
purine transmembrane transporter activity,
polyol transmembrane transporter activity,
water channel activity,
amine transmembrane transporter activity,
carboxylic acid transmembrane transporter activity,
pyrimidine transmembrane transporter activity,
porin activity		 integral to plasma membrane,
intracellular membrane-bounded organelle		 metabolic process,
response to osmotic stress,
response to mercury ion,
water homeostasis,
excretion,
immune response,
cellular response to cAMP
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 11 MQPEGAEKGKSFKQRLVLKSS PKC_zeta 17346701
LTP
0.09
 - -
0.21
 - low
S 222 GCAMNPARDLSPRLFTALAGW PKC_zeta 17346701
LTP
0.05
 - MIP
0.06
 - low

Substrate: Caspase 9 (Cysteine protease)
Seq-ID: P55211 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15372   APAF_HUMAN
MINT-18815   CASP3_HUMAN
MINT-25026   XIAP_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
enzyme activator activity,
cysteine-type endopeptidase activity,
protein binding		 cytosol proteolysis,
activation of caspase activity by cytochrome c
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 144 GGFGDVGALESLRGNADLAYI PKC_zeta 16287866
LTP
0.00
 - -
0.16
 1NW9 64.75%

Substrate: CPI-17 (Inhibitor of PPP1CA)
Seq-ID: Q96A00 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
MINT-16604   KC1A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoprotein phosphatase inhibitor activity,
protein binding		 cytoplasm regulation of phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 38 GGLQKRHARVTVKYDRRELQR PKC_zeta 15003508
LTP
1.00
 MOD_PKA_2
 - PP1_inhibitor
0.51
 - medium

Substrate: GEM (GTP binding, protein binding)
Seq-ID: P55040 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-68066   PDLI7_HUMAN
MINT-3388383   CACB1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
magnesium ion binding,
GDP binding,
GTPase activity,
GTP binding,
calmodulin binding		 internal side of plasma membrane immune response,
cell surface receptor linked signaling pathway,
small GTPase mediated signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 261 RRLAYQKRKESMPRKARRFWG PKC_zeta 14701738
LTP
1.00
 - -
0.38
 - medium

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35568 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19010   INSR_HUMAN
MINT-68735   P85A_HUMAN
MINT-74551   EGFR_HUMAN
MINT-74553   ERBB2_HUMAN
MINT-3975430   1433S_HUMAN
MINT-6628637   LT_SV40
MINT-6793745   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
protein kinase C binding,
insulin-like growth factor receptor binding,
insulin receptor binding,
transmembrane receptor protein tyrosine kinase docking protein activity,
SH2 domain binding		 microsome,
caveola,
cytosol,
insulin receptor complex,
nucleus		 negative regulation of insulin receptor signaling pathway,
glucose homeostasis,
positive regulation of insulin receptor signaling pathway,
positive regulation of fatty acid beta-oxidation,
phosphoinositide 3-kinase cascade,
negative regulation of insulin secretion,
positive regulation of glycogen biosynthetic process,
insulin receptor signaling pathway,
positive regulation of glucose import,
positive regulation of phosphoinositide 3-kinase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 323 PASMVGGKPGSFRVRASSDGE PKC_zeta 15516986
LTP
0.05
 - -
0.79
 --
S 323 PASMVGGKPGSFRVRASSDGE PKC_zeta 16129678
LTP
0.05
 - -
0.79
 --

Substrate: p65 (Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit), RelA)
Seq-ID: Q04206 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-50016   IKBA_MOUSE
MINT-50017   IKBB_MOUSE
MINT-50025   KAPCA_HUMAN
MINT-50073   KS6A5_HUMAN
MINT-50084   KPCZ_HUMAN
MINT-50090   CSK21_HUMAN
MINT-50107   IKKA_HUMAN
MINT-50167   IKKB_HUMAN
MINT-50171   HDAC1_HUMAN
MINT-50175   KAT2B_HUMAN
MINT-50178   EP300_HUMAN
MINT-50179   HDAC3_HUMAN
MINT-58638   NCF1_HUMAN
MINT-62399   TF2B_HUMAN
MINT-2834593   NCOA3_HUMAN
MINT-6166971   OGT1_HUMAN
MINT-7235700   ASPP2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription repressor activity,
transcription repressor binding,
identical protein binding,
protein kinase binding,
ubiquitin protein ligase binding,
transcription activator binding,
transcription activator activity,
RNA polymerase II transcription factor activity, enhancer binding,
promoter binding,
protein N-terminus binding,
phosphate binding,
NF-kappaB binding		 cytosol,
transcription factor complex		 transcription,
positive regulation of I-kappaB kinase/NF-kappaB cascade,
cytokine-mediated signaling pathway,
anti-apoptosis,
defense response to virus,
membrane protein intracellular domain proteolysis,
cellular defense response,
inflammatory response,
nucleotide-binding oligomerization domain containing 2 signaling pathway,
response to interleukin-1,
interspecies interaction between organisms,
positive regulation of NF-kappaB transcription factor activity,
positive regulation of transcription from RNA polymerase II promoter,
response to UV-B,
negative regulation of gene-specific transcription
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 311 KRKRTYETFKSIMKKSPFSGP PKC_zeta 15210811
LTP
0.24
 - -
0.54
 1K3Z 36.89%

Substrate: p65 (Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit), RelA)
Seq-ID: Q04207 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19530   IKBA_MOUSE
MINT-19560   IKBB_MOUSE
MINT-7288484   UBIQ_MOUSE
MINT-7288511   CUL2_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription activator activity,
RNA polymerase II transcription factor activity, enhancer binding,
chromatin binding		 cytosol transcription,
organ morphogenesis,
negative regulation of protein catabolic process,
hair follicle development,
liver development,
positive regulation of interleukin-12 biosynthetic process,
response to muramyl dipeptide
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 311 KRKRTYETFKSIMKKSPFNGP PKC_zeta 12881425
LTP
0.31
 - -
0.55
 1K3Z 36.89%

Substrate: PKC zeta (Protein kinase C, zeta)
Seq-ID: Q05513 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-50084   TF65_HUMAN
MINT-4085674   PAR6A_HUMAN
MINT-4085708   JAM1_HUMAN
MINT-4298316   NUMB_DROME
MINT-7232672   AKT1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase C activity,
insulin receptor substrate binding,
ATP binding,
zinc ion binding		 endosome,
cytosol		 negative regulation of insulin receptor signaling pathway,
anti-apoptosis,
negative regulation of peptidyl-tyrosine phosphorylation,
signal transduction,
peptidyl-serine phosphorylation,
negative regulation of protein complex assembly
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 560 TQFTSEPVQLTPDDEDAIKRI PKC_zeta 9748166
LTP
0.96
 - S_TK_X
0.53
 - medium

Substrate: Ribosomal protein S6 kinase 2 (Ser/Thr protein kinase family)
Seq-ID: Q9UBS0 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15495   EF2K_HUMAN
MINT-51121   COASY_HUMAN
MINT-2833483   RS6_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding		 nucleoplasm positive regulation of translational initiation,
translation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 473 PIRPPSGTKKSKRGRGRPGR  PKC_zeta 12529391
LTP
0.11
 - -
0.94
 - medium

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