Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Cysteine-rich protein 2
Formin homology 2 domain containing 1
GABA(A) receptor B1
HRH1
JAW1-related protein MRVI1A long isoform
LASP1
Phosphodiesterase 5A
Ras-related protein Rap-1b
RGS2
Splicing factor 1
VASP

Substrate:

Cysteine-rich protein 2 (Adapter molecule)

Seq-ID:

P52943 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-2857800 ATN1_HUMAN

GO-Terms:

Molecular Function	Cellular Component	Biological Process
zinc ion binding

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	104	PAARAEERKASGPPKGPSRAS	PKG1/cGK-I	10681529	LTP	0.36		-	-	0.76	-	medium

Substrate:

Formin homology 2 domain containing 1 (Cytoskeletal protein)

Seq-ID:

Q9Y613 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-51615 RAC1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
actin binding	cytoplasm, cytoskeleton, nucleus	actin cytoskeleton organization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1131	RALAARERKRSRGNRKSLRRT	PKG1/cGK-I	15051728	LTP	1.00		-	-	0.82	-	medium

Substrate:

GABA(A) receptor B1 (gamma-aminobutyric-acid receptor beta-1 subunit precursor (from PhosphoBase))

Seq-ID:

P50571 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
chloride channel activity, extracellular ligand-gated ion channel activity	cell junction, chloride channel complex, postsynaptic membrane

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	434	PGKGRIRRRASQLKVKIPDLT	PKG1/cGK-I	8027073	LTP	0.79		-	Neur_chan_memb	0.43	-	low

Substrate:

HRH1 (G-protein coupled receptor activity, histamine receptor activity)

Seq-ID:

P35367 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
histamine receptor activity	integral to plasma membrane	inflammatory response, activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	396	YIKFTWKRLRSHSRQYVSGLH	PKG1/cGK-I	15107581	LTP	0.22		-	7tm_1	0.12	-	medium
S	398	KFTWKRLRSHSRQYVSGLHMN	PKG1/cGK-I	15107581	LTP	1.00		-	7tm_1	0.19	-	medium

Substrate:

Seq-ID:

Q9Y6F6 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	sarcoplasmic reticulum, integral to membrane, endoplasmic reticulum membrane, perinuclear region of cytoplasm

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	689	ALNLPGQTPSSSSIPSLPALS	PKG1/cGK-I	11309393	LTP	1.00		-	-	0.74	-	medium

Substrate:

LASP1 (Cytoskeletal protein)

Seq-ID:

Q14847 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-66300 TRP13_HUMAN
MINT-66313 PLS1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ion transmembrane transporter activity, SH3/SH2 adaptor activity, zinc ion binding, actin binding	focal adhesion, cortical actin cytoskeleton

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	146	GEGMEPERRDSQDGSSYRRPL	PKG1/cGK-I	12571245	LTP	0.95	MOD_PKA_1	-	-	0.90	-	low

Substrate:

LASP1 (Cytoskeletal protein)

Seq-ID:

Q61792 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ion transmembrane transporter activity, zinc ion binding, actin filament binding	focal adhesion, cortical actin cytoskeleton

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	156	AQDSSSYRRPTEQQQPQPHHI	PKG1/cGK-I	15465019	LTP	0.05		-	-	0.94	-	low

Substrate:

Phosphodiesterase 5A (Enzyme: Phosphodiesterase)

Seq-ID:

O76074 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cGMP binding, 3`,5`-cyclic-GMP phosphodiesterase activity, zinc ion binding		signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	102	SVPGTPTRKISASEFDRPLRP	PKG1/cGK-I	11723116	LTP	1.00	MOD_PKA_1	-	-	0.54	-	medium

Substrate:

Ras-related protein Rap-1b (ras-related protein rap-1b (GTP-binding protein smg p21b) (from PhosphoBase))

Seq-ID:

P61224 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-48838 M3K14_HUMAN
MINT-6543629 RPGP1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
GDP binding, GTPase activity, GTP binding, protein binding	plasma membrane, cytosol

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	179	TPVPGKARKKSSCQLL	PKG1/cGK-I	1551424	LTP	0.55	MOD_PKA_1	-	-	0.42	-	low

Substrate:

RGS2 (GTPase activating protein)

Seq-ID:

P41220 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-63728   HSP7C_HUMAN
MINT-63731   DDR1_HUMAN
MINT-63733   WDR74_HUMAN
MINT-63734   ARFG1_HUMAN
MINT-63738   GIT1_HUMAN
MINT-67741   NINL_HUMAN
MINT-4953445   NEB1_HUMAN
MINT-4953730   NEB2_MOUSE
MINT-4953767   Q7TN74_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
GTPase activator activity, calmodulin binding, signal transducer activity		negative regulation of signal transduction, cell cycle, regulation of G-protein coupled receptor protein signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	46	TLLKDWKTRLSYFLQNSSTPG	PKG1/cGK-I	14608379	LTP	0.19		-	-	0.30	-	medium
S	64	TPGKPKTGKKSKQQAFIKPSP	PKG1/cGK-I	14608379	LTP	0.14		-	-	0.72	-	medium

Substrate:

Splicing factor 1 (RNA binding protein)

Seq-ID:

Q15637 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-62843 CD2B2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
RNA polymerase II transcription factor activity, transcription corepressor activity, RNA binding, zinc ion binding	ribosome, spliceosomal complex	nuclear mRNA 3`-splice site recognition, transcription

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	20	LDFPSKKRKRSRWNQDTMEQK	PKG1/cGK-I	10449420	LTP	1.00		-	-	0.74	-	low

Substrate:

VASP (vasodilator-stimulated phosphoprotein (vasp) (from PhosphoBase))

Seq-ID:

P70460 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-51624 AB1IP_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding, actin binding	focal adhesion, cytosol, cytoskeleton, lamellipodium membrane, filopodium membrane	axon guidance, actin cytoskeleton organization, neural tube closure

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	153	RQPEHMERRVSNAGGPPAPPA	PKG1/cGK-I	10085070	LTP	0.95		-	-	0.97	-	low