Click on substrate name for additional information.


Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35568 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19010   INSR_HUMAN
MINT-68735   P85A_HUMAN
MINT-74551   EGFR_HUMAN
MINT-74553   ERBB2_HUMAN
MINT-3975430   1433S_HUMAN
MINT-6628637   LT_SV40
MINT-6793745   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
protein kinase C binding,
insulin-like growth factor receptor binding,
insulin receptor binding,
transmembrane receptor protein tyrosine kinase docking protein activity,
SH2 domain binding		 microsome,
caveola,
cytosol,
insulin receptor complex,
nucleus		 negative regulation of insulin receptor signaling pathway,
glucose homeostasis,
positive regulation of insulin receptor signaling pathway,
positive regulation of fatty acid beta-oxidation,
phosphoinositide 3-kinase cascade,
negative regulation of insulin secretion,
positive regulation of glycogen biosynthetic process,
insulin receptor signaling pathway,
positive regulation of glucose import,
positive regulation of phosphoinositide 3-kinase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 794 ARHQHLRLSTSSGRLLYAATA SIK 12624099
LTP
1.00
 - -
0.65
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