Click on substrate name for additional information.


Substrate: TGF beta R, type II (Dual specificity kinase)
Seq-ID: P37173 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
glycosaminoglycan binding,
transforming growth factor beta receptor activity, type II,
transforming growth factor beta binding,
metal ion binding,
SMAD binding,
type I transforming growth factor beta receptor binding,
ATP binding,
type III transforming growth factor beta receptor binding,
protein binding		 external side of plasma membrane,
caveola,
transforming growth factor beta receptor complex		 pathway-restricted SMAD protein phosphorylation,
positive regulation of mesenchymal cell proliferation,
positive regulation of tolerance induction to self antigen,
patterning of blood vessels,
response to cholesterol,
response to drug,
activation of protein kinase activity,
positive regulation of T cell tolerance induction,
peptidyl-serine phosphorylation,
heart development,
embryonic cranial skeleton morphogenesis,
positive regulation of NK T cell differentiation,
vasculogenesis,
embryonic hemopoiesis,
transforming growth factor beta receptor signaling pathway,
palate development,
peptidyl-threonine phosphorylation,
myeloid dendritic cell differentiation,
positive regulation of B cell tolerance induction,
brain development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 213 TGKTRKLMEFSEHCAIILEDD TGFbR2 9155023
LTP
1.00
 - -
0.18
 - medium
Y 259 LVGKGRFAEVYKAKLKQNTSE TGFbR2 9169454
LTP
0.14
 - STYKc
0.22
 - medium
Y 336 AFHAKGNLQEYLTRHVISWED TGFbR2 9169454
LTP
0.97
 - STYKc
0.14
 - medium
S 409 GLSLRLDPTLSVDDLANSGQV TGFbR2 9155023
LTP
1.00
 - STYKc
0.31
 - medium
S 416 PTLSVDDLANSGQVGTARYMA TGFbR2 9155023
LTP
0.32
 - STYKc
0.37
 - medium
Y 424 ANSGQVGTARYMAPEVLESRM TGFbR2 9169454
LTP
1.00
 - STYKc
0.41
 - medium

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