Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

Click on substrate name for additional information.

Substrate: TIE2 (TEK) (PTK receptor for angiopoietin 1)

Seq-ID: Q02763 [Homo sapiens]

Download: fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s): -

GO-Terms:
[show]

Molecular Function Cellular Component Biological Process

transmembrane receptor protein tyrosine kinase activity,
ATP binding,
protein binding basolateral plasma membrane,
integral to plasma membrane,
cell surface,
microvillus,
apical plasma membrane,
membrane raft positive regulation of ERK1 and ERK2 cascade,
protein amino acid phosphorylation,
protein oligomerization,
cell-cell signaling,
positive regulation of protein kinase B signaling cascade,
regulation of cell proliferation,
transmembrane receptor protein tyrosine kinase signaling pathway

Conservation:

Click on table headers for sorting

Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.

Y 992 DFGLSRGQEVYVKKTMGRLPV TIE2 11513602
LTP

1.00
- TyrKc
0.13
1FVR 62.01%

Y 1048 PYCGMTCAELYEKLPQGYRLE TIE2 11513602
LTP

1.00
- TyrKc
0.12
1FVR 39.30%

Y 1102 LNRMLEERKTYVNTTLYEKFT TIE2 12082108
LTP

1.00
GRB2 SH2;
GRB7 SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2 -
0.15
1FVR 3.49%

Y 1108 ERKTYVNTTLYEKFTYAGIDC TIE2 10521483
LTP

0.08
DOK_group PTB;
GRB14 SH2;
PIK3R1 SH2 -
0.11
1FVR 76.42%

Y 1108 ERKTYVNTTLYEKFTYAGIDC TIE2 12665569
LTP

0.08
DOK_group PTB;
GRB14 SH2;
PIK3R1 SH2 -
0.11
1FVR 76.42%

Y 1113 VNTTLYEKFTYAGIDCSAEEA TIE2 10521483
LTP

1.00
PIK3R1 SH2;
PTPN11 SH2 -
0.12
1FVR 15.72%

Substrate: TIE2 (TEK) (PTK receptor for angiopoietin 1)

Seq-ID: Q02858 [Mus musculus]

Download: fasta csv

Interaction Network(s): -

External Source(s):

MINT Interaction(s): -

GO-Terms:
[show]

Molecular Function Cellular Component Biological Process

transmembrane receptor protein tyrosine kinase activity,
ATP binding,
protein binding integral to plasma membrane protein amino acid phosphorylation,
regulation of angiogenesis,
angiogenesis,
regulation of cell migration,
anti-apoptosis,
positive regulation of peptidyl-serine phosphorylation,
hemopoiesis,
positive regulation of cell adhesion,
cell-matrix adhesion,
regulation of cell proliferation,
transmembrane receptor protein tyrosine kinase signaling pathway,
response to retinoic acid,
cell-cell adhesion

Conservation:

Click on table headers for sorting

Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.

Y 1100 LNRMLEERKTYVNTTLYEKFT TIE2 10521483
LTP

1.00
- -
0.15
1FVR 3.49%

Y 1100 LNRMLEERKTYVNTTLYEKFT TIE2 11865050
LTP

1.00
- -
0.15
1FVR 3.49%