| Name | Description | Molecular Function | Cellular Component | Biological Process |
|---|
| Histone deacetylase 9 |
unclassified |
protein kinase C binding,
specific transcriptional repressor activity,
transcription corepressor activity,
histone deacetylase binding,
transcription repressor activity,
transcription repressor binding,
histone deacetylase activity |
cytoplasm,
transcription factor complex,
histone deacetylase complex,
histone methyltransferase complex |
negative regulation of gene-specific transcription from RNA polymerase II promoter,
inflammatory response,
heart development,
histone H3 deacetylation,
regulation of skeletal muscle fiber development,
cellular response to insulin stimulus,
peptidyl-lysine deacetylation,
B cell differentiation,
transcription,
histone H4 deacetylation,
positive regulation of cell migration involved in sprouting angiogenesis |
| Acetylcholine receptor protein, beta chain |
Acetylcholine receptor |
nicotinic acetylcholine-activated cation-selective channel activity,
receptor activity |
cell junction,
integral to membrane,
postsynaptic membrane |
|
| Acetylcholine receptor protein, delta chain |
Acetylcholine receptor |
nicotinic acetylcholine-activated cation-selective channel activity,
receptor activity |
cell junction,
integral to membrane,
postsynaptic membrane |
|
| Acetylcholine receptor protein, gamma chain |
Acetylcholine receptor |
nicotinic acetylcholine-activated cation-selective channel activity,
receptor activity |
cell junction,
integral to membrane,
postsynaptic membrane |
|
| Acetylcholinesterase |
Enzyme |
serine hydrolase activity,
collagen binding,
laminin-1 binding,
cholinesterase activity,
beta-amyloid binding,
protein homodimerization activity,
acetylcholine binding,
acetylcholinesterase activity |
cell junction,
anchored to membrane,
Golgi apparatus,
perinuclear region of cytoplasm,
synapse,
nucleus,
basal lamina |
amyloid precursor protein metabolic process,
osteoblast development,
positive regulation of protein secretion,
negative regulation of synaptic transmission, cholinergic,
synapse assembly,
DNA replication,
cell proliferation,
response to wounding,
muscle organ development,
cell adhesion,
acetylcholine catabolic process in synaptic cleft |
| Muscarinic acetylcholine receptor M2 |
muscarinic acetylcholine receptor M2 (from PhosphoBase) |
muscarinic acetylcholine receptor activity,
protein binding |
cell junction,
integral to membrane,
integral to plasma membrane,
postsynaptic membrane |
activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway,
G-protein signaling, coupled to cAMP nucleotide second messenger,
nervous system development,
regulation of heart contraction,
response to virus |
| Histone deacetylase 4 |
Enzyme: Deacetylase |
specific transcriptional repressor activity,
histone deacetylase binding,
potassium ion binding,
transcription repressor binding,
transcription activator binding,
transcription activator activity,
histone deacetylase activity,
zinc ion binding |
histone deacetylase complex,
transcriptional repressor complex |
negative regulation of gene-specific transcription from RNA polymerase II promoter,
positive regulation of gene-specific transcription from RNA polymerase II promoter,
inflammatory response,
histone H3 deacetylation,
response to interleukin-1,
chromatin remodeling,
cardiac muscle hypertrophy in response to stress,
negative regulation of glycolysis,
positive regulation of protein sumoylation,
peptidyl-lysine deacetylation,
B cell differentiation,
nervous system development,
positive regulation of cell proliferation,
negative regulation of transcription factor activity,
negative regulation of myotube differentiation,
transcription,
histone H4 deacetylation,
positive regulation of transcription factor activity,
response to denervation involved in regulation of muscle adaptation,
regulation of protein binding |
| Acetyl-CoA carboxylase 1 |
Enzyme: Carboxylase |
metal ion binding,
ATP binding,
biotin binding,
acetyl-CoA carboxylase activity,
biotin carboxylase activity,
protein binding |
soluble fraction,
mitochondrion |
response to drug,
fatty acid biosynthetic process,
tissue homeostasis,
multicellular organismal protein metabolic process,
response to organic cyclic substance,
acetyl-CoA metabolic process,
lipid homeostasis |
| Histone deacetylase 1 |
Cell cycle control protein |
identical protein binding,
specific transcriptional repressor activity,
transcription corepressor activity,
chromatin binding,
histone deacetylase binding,
transcription activator activity,
histone deacetylase activity,
transcription factor binding,
sequence-specific DNA binding transcription factor activity |
neuronal cell body,
Sin3 complex,
cytoplasm,
NuRD complex,
cytosol,
heterochromatin |
negative regulation of gene-specific transcription from RNA polymerase II promoter,
positive regulation of gene-specific transcription from RNA polymerase II promoter,
hippocampus development,
negative regulation by host of viral transcription,
histone H3 deacetylation,
chromatin remodeling,
neuron differentiation,
positive regulation of cell proliferation,
transcription,
histone H4 deacetylation,
anti-apoptosis,
endoderm development,
positive regulation of receptor biosynthetic process,
negative regulation of cell cycle |
| Serotonin acetylase |
Enzyme: Acyltransferase |
aralkylamine N-acetyltransferase activity |
cytosol |
melatonin biosynthetic process,
circadian rhythm |
| Histone deacetylase 2 |
Enzyme: Deacetylase |
specific transcriptional repressor activity,
enzyme binding,
sequence-specific DNA binding,
transcription activator activity,
histone deacetylase activity,
transcription factor binding,
sequence-specific DNA binding transcription factor activity |
ESC/E(Z) complex,
Sin3 complex,
cytoplasm,
NuRD complex,
heterochromatin,
replication fork |
negative regulation of gene-specific transcription from RNA polymerase II promoter,
positive regulation of gene-specific transcription from RNA polymerase II promoter,
hippocampus development,
chromatin remodeling,
neuron differentiation,
maintenance of chromatin silencing,
positive regulation of cell proliferation,
negative regulation of transcription factor activity,
transcription,
positive regulation of proteolysis,
histone deacetylation,
positive regulation of receptor biosynthetic process,
negative regulation of MHC class II biosynthetic process,
positive regulation of collagen biosynthetic process,
negative regulation of cell cycle |
| Histone acetyltransferase HTATIP |
Enzyme: Acyltransferase |
metal ion binding,
androgen receptor binding,
chromatin binding,
transcription repressor activity,
transcription repressor binding,
histone acetyltransferase activity,
transcription coactivator activity |
NuA4 histone acetyltransferase complex,
perinuclear region of cytoplasm,
Piccolo NuA4 histone acetyltransferase complex,
chromatin,
nucleolus |
negative regulation of gene-specific transcription from RNA polymerase II promoter,
positive regulation of transcription, DNA-dependent,
chromatin assembly or disassembly,
interspecies interaction between organisms,
double-strand break repair,
negative regulation of interleukin-2 production,
transcription,
regulation of growth,
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,
androgen receptor signaling pathway,
histone acetylation |
| Histone acetyltransferase MYST4 |
Enzyme: Acyltransferase |
DNA binding,
transcription repressor activity,
histone acetyltransferase activity,
transcription activator activity,
transcription factor binding,
zinc ion binding |
nucleosome,
MOZ/MORF histone acetyltransferase complex |
regulation of transcription, DNA-dependent,
transcription,
nucleosome assembly,
histone H3 acetylation |
| Histone deacetylase 6 |
Enzyme: Deacetylase |
Hsp90 protein binding,
specific transcriptional repressor activity,
histone deacetylase binding,
dynein complex binding,
alpha-tubulin binding,
actin binding,
tau protein binding,
histone deacetylase activity,
beta-catenin binding,
microtubule binding,
tubulin deacetylase activity,
zinc ion binding,
polyubiquitin binding |
caveola,
cytosol,
microtubule associated complex,
perinuclear region of cytoplasm,
histone deacetylase complex,
aggresome,
cell leading edge |
aggresome assembly,
response to toxin,
negative regulation of proteolysis,
regulation of receptor activity,
positive regulation of apoptosis,
negative regulation of oxidoreductase activity,
lysosome localization,
regulation of androgen receptor signaling pathway,
macroautophagy,
negative regulation of hydrogen peroxide metabolic process,
peptidyl-lysine deacetylation,
tubulin deacetylation,
misfolded or incompletely synthesized protein catabolic process,
cellular response to hydrogen peroxide,
transcription,
positive regulation of cellular chaperone-mediated protein complex assembly,
response to growth factor stimulus,
histone deacetylation,
positive regulation of signal transduction,
regulation of microtubule-based movement,
positive regulation of receptor biosynthetic process,
Hsp90 deacetylation,
polyubiquitinated misfolded protein transport,
positive regulation of epithelial cell migration |
| Cancer associated surface antigen RCAS1 |
Receptor-binding cancer antigen |
apoptotic protease activator activity,
protein binding |
integral to membrane,
soluble fraction,
Golgi membrane,
focal adhesion,
stored secretory granule |
regulation of cell growth,
apoptosis |
| BACE1 |
aspartic-type endopeptidase activity, beta-aspartyl-peptidase activity |
beta-aspartyl-peptidase activity,
aspartic-type endopeptidase activity,
protein binding |
endoplasmic reticulum,
endosome,
integral to plasma membrane,
trans-Golgi network,
cell surface |
beta-amyloid metabolic process,
membrane protein ectodomain proteolysis |
| ACE |
Enzyme: carboxypeptidase |
peptidyl-dipeptidase activity,
chloride ion binding,
bradykinin receptor binding,
actin binding,
drug binding,
metallopeptidase activity,
carboxypeptidase activity,
zinc ion binding |
plasma membrane,
external side of plasma membrane,
integral to membrane,
membrane fraction,
endosome,
extracellular space |
regulation of blood pressure,
arachidonic acid secretion,
blood vessel remodeling,
regulation of vasoconstriction,
kidney development,
regulation of vasodilation,
regulation of renal output by angiotensin,
peptide catabolic process,
hormone catabolic process,
regulation of smooth muscle cell migration,
hemopoietic stem cell differentiation,
angiotensin catabolic process in blood,
mononuclear cell proliferation,
neutrophil mediated immunity |
| 4F2 cell-surface antigen heavy chain |
calcium:sodium antiporter activity |
calcium:sodium antiporter activity,
neutral amino acid transmembrane transporter activity,
cation binding,
catalytic activity,
protein binding |
melanosome,
integral to membrane,
apical plasma membrane,
cell surface |
cell growth,
carbohydrate metabolic process,
calcium ion transport,
tryptophan transport,
leucine import |
| Acetylserotonin O-methyltrAnsferAse-like |
acetylserotonin O-methyltransferase activity |
acetylserotonin O-methyltransferase activity |
cytoplasm |
melatonin biosynthetic process |
| Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 |
sialyltransferase activity |
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity |
integral to Golgi membrane |
protein amino acid glycosylation |
| Cell surface glycoprotein MUC18 precursor |
unclassified |
|
plasma membrane,
integral to membrane |
anatomical structure morphogenesis,
cell adhesion |
| Histone acetyltransferase MYST2 |
protein binding |
histone acetyltransferase activity,
zinc ion binding,
sequence-specific DNA binding transcription factor activity,
protein binding |
histone acetyltransferase complex |
DNA replication,
regulation of transcription, DNA-dependent,
histone H4-K5 acetylation,
histone H4-K8 acetylation,
transcription,
histone H3 acetylation,
histone H4-K12 acetylation |
| Histone acetyltransferase type B catalytic subunit |
histone acetyltransferase activity |
histone acetyltransferase activity,
protein binding |
cytoplasm,
nucleus |
DNA packaging,
chromatin silencing at telomere,
internal protein amino acid acetylation,
histone acetylation |
| N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase |
3'-phosphoadenosine 5'-phosphosulfate binding |
3`-phosphoadenosine 5`-phosphosulfate binding,
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity |
integral to membrane,
Golgi membrane |
hexose biosynthetic process |
| N-acetyltransferase ESCO2 |
unclassified |
DNA-directed DNA polymerase activity,
metal ion binding,
damaged DNA binding,
acyltransferase activity |
nucleus |
DNA repair,
cell cycle |
| Neuronal acetylcholine receptor protein, alpha-6 subunit precursor |
acetylcholine receptor activity |
nicotinic acetylcholine-activated cation-selective channel activity,
acetylcholine receptor activity |
cell junction,
nicotinic acetylcholine-gated receptor-channel complex,
postsynaptic membrane |
|
| N-terminal acetyltransferase complex ARD1 subunit homolog |
N-acetyltransferase activity |
peptide alpha-N-acetyltransferase activity,
protein binding |
cytoplasm,
nucleus |
DNA packaging,
N-terminal protein amino acid acetylation,
internal protein amino acid acetylation |
| Histone deacetylase 3 |
histone deacetylase activity |
transcription corepressor activity,
histone deacetylase binding,
histone deacetylase activity |
spindle microtubule,
cytoplasm,
histone deacetylase complex,
transcriptional repressor complex |
negative regulation of gene-specific transcription from RNA polymerase II promoter,
negative regulation of JNK cascade,
spindle assembly,
transcription,
anti-apoptosis,
negative regulation of cell cycle |
| Bromodomain adjacent to zinc finger domain protein 1A |
unclassified |
transcription regulator activity,
zinc ion binding,
protein binding |
ACF complex |
chromatin remodeling,
regulation of transcription, DNA-dependent,
transcription |
| N-acetyltransferase ESCO1 |
|
DNA-directed DNA polymerase activity,
metal ion binding,
damaged DNA binding,
acyltransferase activity |
chromosome,
nucleus |
DNA repair,
cell cycle |
| Histone acetyltransferase MYST3 |
|
DNA binding,
histone acetyltransferase activity,
transcription coactivator activity,
zinc ion binding |
nucleosome,
MOZ/MORF histone acetyltransferase complex |
negative regulation of transcription,
myeloid cell differentiation,
transcription,
nucleosome assembly,
histone H3 acetylation |
| Extracellular domains-containing protein CG31004 |
|
|
integral to membrane |
cell-matrix adhesion |
| Histone deacetylase Rpd3 |
|
transcription corepressor activity,
histone deacetylase activity |
ESC/E(Z) complex,
Sin3 complex,
Myb complex,
cytoplasm,
NuRD complex,
polytene chromosome interband |
tricarboxylic acid cycle,
chromatin silencing,
oogenesis,
blastoderm segmentation,
dendrite morphogenesis,
transcription,
determination of adult lifespan,
histone deacetylation,
respiratory electron transport chain,
muscle organ development |
| N-acetyltransferase eco |
|
DNA-directed DNA polymerase activity,
metal ion binding,
damaged DNA binding,
N-acetyltransferase activity,
protein binding |
nuclear chromatin |
DNA repair,
mitotic spindle organization,
mitotic sister chromatid cohesion |
