| Name | Description | Molecular Function | Cellular Component | Biological Process |
|---|
| BRCA1 |
Breast cancer type 1 susceptibility protein |
DNA binding,
identical protein binding,
androgen receptor binding,
RNA binding,
damaged DNA binding,
tubulin binding,
ubiquitin-protein ligase activity,
transcription regulator activity,
ubiquitin protein ligase binding,
zinc ion binding,
transcription coactivator activity,
protein binding |
ribonucleoprotein complex,
gamma-tubulin ring complex,
centrosome,
condensed chromosome,
BRCA1-A complex,
nucleoplasm,
nucleus,
BRCA1-BARD1 complex |
positive regulation of gene-specific transcription from RNA polymerase II promoter,
negative regulation of centriole replication,
apoptosis,
cellular response to indole-3-methanol,
fatty acid biosynthetic process,
G2/M transition DNA damage checkpoint,
negative regulation of transcription,
centrosome cycle,
DNA replication,
DNA damage response, signal transduction resulting in induction of apoptosis,
dosage compensation, by inactivation of X chromosome,
chordate embryonic development,
DNA repair,
protein autoubiquitination,
response to estrogen stimulus,
chromosome segregation,
regulation of transcription from RNA polymerase III promoter,
cell cycle,
centrosome duplication,
postreplication repair,
positive regulation of protein ubiquitination,
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,
positive regulation of DNA repair,
negative regulation of fatty acid biosynthetic process,
androgen receptor signaling pathway,
regulation of cell proliferation,
protein K6-linked ubiquitination,
double-strand break repair via homologous recombination,
response to ionizing radiation |
| BRCA1 associated protein1 |
Ubiquitin proteasome system protein |
ubiquitin-specific protease activity,
chromatin binding,
ubiquitin thiolesterase activity,
protein binding |
cytoplasm,
PR-DUB complex |
regulation of cell growth,
negative regulation of cell proliferation,
ubiquitin-dependent protein catabolic process,
regulation of cell cycle,
monoubiquitinated histone H2A deubiquitination,
protein K48-linked deubiquitination |
| BRCA1 interacting protein 1 |
Transcription factor |
DNA binding,
ATP binding,
ATP-dependent DNA helicase activity,
protein binding |
cytoplasm,
nucleus |
DNA damage checkpoint,
double-strand break repair,
regulation of transcription from RNA polymerase II promoter |
